PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT3G10480.3
Common NameANAC050, NAC050
Organism
Arabidopsis thaliana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family NAC
Protein Properties Length: 526aa    MW: 59463.1 Da    PI: 6.3353
Description NAC domain containing protein 50
Gene Model
Gene Model ID Type Source Coding Sequence
AT3G10480.3genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM159.31.6e-49271871128
          NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpk...................................kvkaeekewyfFsk 63 
                  l+pGfrFhPtdeelv++yLk+kv gk++++ ++i evdiyk+ePwdL +                                   k+k++++ewyfFs 
  AT3G10480.3  27 LAPGFRFHPTDEELVSYYLKRKVLGKPVRF-DAIGEVDIYKHEPWDLAEkilcsylalncfknfvfacatvmfacatvmfalfsKLKTRDQEWYFFSA 123
                  579************************999.99**************84599****************************9999889999******** PP

          NAM  64 rdkkyatgkrknratksgyWkatgkdkevlskkgelvglkktLvfykgrapkgektdWvmheyrl 128
                   dkky +g r nrat++gyWkatgkd+e+ + + +l g+kktLvf++grap+g +t+Wvmheyrl
  AT3G10480.3 124 LDKKYGNGARMNRATNKGYWKATGKDREIRR-DIQLLGMKKTLVFHSGRAPDGLRTNWVMHEYRL 187
                  ******************************9.999****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019416.15E-192082IPR003441NAC domain
PROSITE profilePS5100553.33727211IPR003441NAC domain
PfamPF023651.2E-2629187IPR003441NAC domain
SuperFamilySSF1019414.05E-37107212IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010228Biological Processvegetative to reproductive phase transition of meristem
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0016021Cellular Componentintegral component of membrane
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000005anatomycultured plant cell
PO:0000293anatomyguard cell
Sequence ? help Back to Top
Protein Sequence    Length: 526 aa     Download sequence    Send to blast
MGRESLAVVS SPPSATAPST AVSATSLAPG FRFHPTDEEL VSYYLKRKVL GKPVRFDAIG  60
EVDIYKHEPW DLAEKILCSY LALNCFKNFV FACATVMFAC ATVMFALFSK LKTRDQEWYF  120
FSALDKKYGN GARMNRATNK GYWKATGKDR EIRRDIQLLG MKKTLVFHSG RAPDGLRTNW  180
VMHEYRLVEY ETETNGSLLQ DAYVLCRVFH KNNIGPPSGN RYAPFMEEEW ADGGGALIPG  240
IDVRVRVEAL PQANGNNQMD QWADLLKLHN SIKFAITFCR TQLNLTALSN ERCSTREIFI  300
VFWLICKEMH SASKDLININ ELPRDATPMD IEPNQQNHHE SAFKPQESNN HSGYEEDEDT  360
LKREHAEEDE RPPSLCILNK EAPLPLLQYK RRRQNESNNN SSRNTQDHCS STITTVDNTT  420
TLISSSAAAA TNTAISALLE FSLMGISDKK ENQQKEETSP PSPIASPEEK VNDLQKEVHQ  480
MSVERETFKL EMMSAEAMIS ILQSRIDALR QENEELKKKN ASGQAS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3swm_A3e-452221315170NAC domain-containing protein 19
3swm_B3e-452221315170NAC domain-containing protein 19
3swm_C3e-452221315170NAC domain-containing protein 19
3swm_D3e-452221315170NAC domain-containing protein 19
3swp_A3e-452221315170NAC domain-containing protein 19
3swp_B3e-452221315170NAC domain-containing protein 19
3swp_C3e-452221315170NAC domain-containing protein 19
3swp_D3e-452221315170NAC domain-containing protein 19
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.201140.0flower| silique
Expression -- Microarray ? help Back to Top
Source ID E-value
Genevisible258926_s_at1e-140
Expression AtlasAT3G10480-
AtGenExpressAT3G10480-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Mostly expressed in floral organs, and, at low levels, in other organs. {ECO:0000269|PubMed:25578968}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional repressor that binds to the motif 5'-(C/T)A(C/A)G-3' in the promoter of target genes (PubMed:25578968). Binds also to the 5'-CTTGNNNNNCAAG-3' consensus sequence in chromatin (PubMed:26617990). Can bind to the mitochondrial dysfunction motif (MDM) present in the upstream regions of mitochondrial dysfunction stimulon (MDS) genes involved in mitochondrial retrograde regulation (MRR) (PubMed:24045019). Together with NAC051/NAC052 and JMJ14, regulates gene expression and flowering time by associating with the histone demethylase JMJ14, probably by the promotion of RNA-mediated gene silencing (PubMed:25578968, PubMed:26617990). {ECO:0000269|PubMed:24045019, ECO:0000269|PubMed:25578968, ECO:0000269|PubMed:26617990}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00342DAP27203113Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT3G10480.3
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Interaction ? help Back to Top
Source Intact With
BioGRIDAT3G10480, AT3G10490, AT1G14920
IntActSearch F4J3S6
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT3G10480
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0115600.0AC011560.6 Arabidopsis thaliana chromosome 3 BAC F13M14 genomic sequence, complete sequence.
GenBankATAC0134280.0AC013428.6 Arabidopsis thaliana chromosome III BAC F18K10 genomic sequence, complete sequence.
GenBankCP0026860.0CP002686.1 Arabidopsis thaliana chromosome 3, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001154602.10.0NAC domain containing protein 50
SwissprotQ9SQX90.0NAC50_ARATH; NAC domain containing protein 50
TrEMBLF4J3S60.0F4J3S6_ARATH; NAC domain containing protein 50
STRINGAT3G10480.30.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM17802880
Representative plantOGRP1087158
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Ooka H, et al.
    Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana.
    DNA Res., 2003. 10(6): p. 239-47
    [PMID:15029955]
  3. Ishihara T, et al.
    Comparative analysis of expressed sequence tags in resistant and susceptible ecotypes of Arabidopsis thaliana infected with cucumber mosaic virus.
    Plant Cell Physiol., 2004. 45(4): p. 470-80
    [PMID:15111722]
  4. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
    [PMID:21798944]
  5. Causier B,Ashworth M,Guo W,Davies B
    The TOPLESS interactome: a framework for gene repression in Arabidopsis.
    Plant Physiol., 2012. 158(1): p. 423-38
    [PMID:22065421]
  6. De Clercq I, et al.
    The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis.
    Plant Cell, 2013. 25(9): p. 3472-90
    [PMID:24045019]
  7. Mar
    Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
    Plant Physiol., 2014. 166(2): p. 1022-32
    [PMID:25118255]
  8. We
    Convergent targeting of a common host protein-network by pathogen effectors from three kingdoms of life.
    Cell Host Microbe, 2014. 16(3): p. 364-75
    [PMID:25211078]
  9. Ning YQ, et al.
    Two novel NAC transcription factors regulate gene expression and flowering time by associating with the histone demethylase JMJ14.
    Nucleic Acids Res., 2015. 43(3): p. 1469-84
    [PMID:25578968]
  10. Zhang S, et al.
    C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association.
    Cell Discov, 2019.
    [PMID:26617990]