PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G47520.1
Common NameAtERF71, ERF071, ERF71, HRE2, T30B22.18
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 171aa    MW: 19346.6 Da    PI: 6.8342
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G47520.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2  3 ykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                 y+G+r+++ +g+W+AeIrdps+     r++lg+f ta+eAa+a++ a+ k++g
                 9*******.**********965...4*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541713.99E-2349107IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.103.6E-3349107IPR001471AP2/ERF domain
PROSITE profilePS5103224.86949106IPR001471AP2/ERF domain
SMARTSM003802.0E-4249112IPR001471AP2/ERF domain
CDDcd000186.53E-3550108No hitNo description
PfamPF008476.1E-135098IPR001471AP2/ERF domain
PRINTSPR003671.1E-115061IPR001471AP2/ERF domain
PRINTSPR003671.1E-117288IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009873Biological Processethylene-activated signaling pathway
GO:0034059Biological Processresponse to anoxia
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0009009anatomyplant embryo
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0007611developmental stagepetal differentiation and expansion stage
Sequence ? help Back to Top
Protein Sequence    Length: 171 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT2G47520-
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the ERF (ethylene response factor) subfamily B-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. HRE1 and HRE2 encode two nuclear-localized ethylene response factors specifically up-regulated under low oxygen conditions.
    [PMID: 20113439]
  2. AtERF71/HRE2 might function as a transcription factor involved in the response to osmotic stress as well as hypoxia.
    [PMID: 21946064]
  3. AtERF71/HRE2 binds to both GCC box and DRE/CRT, transactivates expression of genes downstream via GCC box or DRE/CRT, and plays an important role in root development through regulation of root cell expansion.
    [PMID: 25344007]
  4. Overexpression of the ERFVII member HRE2 inhibits root bending, suggesting that primary root growth direction at hypoxic conditions is antagonistically regulated by hypoxia and hypoxia-activated ERFVIIs.
    [PMID: 28698356]
  5. Overexpression of HRE2 induces adventitious root (AR) elongation to the same degree as hypoxia, while ethylene overrides HRE2-induced AR elongation.
    [PMID: 29996004]
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G47520
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY0746450.0AY074645.1 Arabidopsis thaliana At2g47520/T30B22.18 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_182274.11e-123Integrase-type DNA-binding superfamily protein
SwissprotO222591e-124ERF71_ARATH; Ethylene-responsive transcription factor ERF071
STRINGAT2G47520.11e-123(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  4. Goda H, et al.
    Comprehensive comparison of auxin-regulated and brassinosteroid-regulated genes in Arabidopsis.
    Plant Physiol., 2004. 134(4): p. 1555-73
  5. Liu F, et al.
    Global transcription profiling reveals comprehensive insights into hypoxic response in Arabidopsis.
    Plant Physiol., 2005. 137(3): p. 1115-29
  6. Gonzali S, et al.
    The use of microarrays to study the anaerobic response in Arabidopsis.
    Ann. Bot., 2005. 96(4): p. 661-8
  7. Branco-Price C,Kawaguchi R,Ferreira RB,Bailey-Serres J
    Genome-wide analysis of transcript abundance and translation in Arabidopsis seedlings subjected to oxygen deprivation.
    Ann. Bot., 2005. 96(4): p. 647-60
  8. Vanderauwera S, et al.
    Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis.
    Plant Physiol., 2005. 139(2): p. 806-21
  9. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  10. Osuna D, et al.
    Temporal responses of transcripts, enzyme activities and metabolites after adding sucrose to carbon-deprived Arabidopsis seedlings.
    Plant J., 2007. 49(3): p. 463-91
  11. Gandia-Herrero F, et al.
    Detoxification of the explosive 2,4,6-trinitrotoluene in Arabidopsis: discovery of bifunctional O- and C-glucosyltransferases.
    Plant J., 2008. 56(6): p. 963-74
  12. Licausi F, et al.
    HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect anaerobic responses in Arabidopsis thaliana.
    Plant J., 2010. 62(2): p. 302-15
  13. Inz
    A subcellular localization compendium of hydrogen peroxide-induced proteins.
    Plant Cell Environ., 2012. 35(2): p. 308-20
  14. Hess N,Klode M,Anders M,Sauter M
    The hypoxia responsive transcription factor genes ERF71/HRE2 and ERF73/HRE1 of Arabidopsis are differentially regulated by ethylene.
    Physiol Plant, 2011. 143(1): p. 41-9
  15. Park HY, et al.
    AtERF71/HRE2 transcription factor mediates osmotic stress response as well as hypoxia response in Arabidopsis.
    Biochem. Biophys. Res. Commun., 2011. 414(1): p. 135-41
  16. Gibbs DJ, et al.
    Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
    Nature, 2011. 479(7373): p. 415-8
  17. Lee SY, et al.
    Arabidopsis AtERF71/HRE2 functions as transcriptional activator via cis-acting GCC box or DRE/CRT element and is involved in root development through regulation of root cell expansion.
    Plant Cell Rep., 2015. 34(2): p. 223-31
  18. Gasch P, et al.
    Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis.
    Plant Cell, 2016. 28(1): p. 160-80
  19. Yao Y,Chen X,Wu AM
    ERF-VII members exhibit synergistic and separate roles in Arabidopsis.
    Plant Signal Behav, 2017. 12(6): p. e1329073
  20. Eysholdt-Derzsó E,Sauter M
    Root Bending Is Antagonistically Affected by Hypoxia and ERF-Mediated Transcription via Auxin Signaling.
    Plant Physiol., 2017. 175(1): p. 412-423
  21. Eysholdt-Derzsó E,Sauter M
    Hypoxia and the group VII ethylene response transcription factor HRE2 promote adventitious root elongation in Arabidopsis.
    Plant Biol (Stuttg), 2019. 21 Suppl 1: p. 103-108