PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT2G40340.1
Common NameAtERF48, DREB2C, ERF048, T07M07.24, T3G21.11
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 341aa    MW: 37829.6 Da    PI: 4.4098
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT2G40340.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2   1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                  ++y+GVr+++ +g+WvAeIr+p   g  +r +lg+f + +eAa a+++a+k+++g
                  68*****998.**********83..3.4***********************9987 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008471.4E-1370120IPR001471AP2/ERF domain
CDDcd000186.56E-3270129No hitNo description
SMARTSM003802.5E-3771134IPR001471AP2/ERF domain
PROSITE profilePS5103220.83771128IPR001471AP2/ERF domain
SuperFamilySSF541719.15E-1972128IPR016177DNA-binding domain
PRINTSPR003677.5E-97283IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.2E-2772129IPR001471AP2/ERF domain
PRINTSPR003677.5E-994110IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009737Biological Processresponse to abscisic acid
GO:0009738Biological Processabscisic acid-activated signaling pathway
GO:0010286Biological Processheat acclimation
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000293anatomyguard cell
Sequence ? help Back to Top
Protein Sequence    Length: 341 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT2G40340-
Functional Description ? help Back to Top
Source Description
TAIREncodes a member of the DREB subfamily A-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are eight members in this subfamily including DREB2A AND DREB2B that are involved in response to drought.
UniProtTranscriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates high salinity- and abscisic acid-inducible transcription. {ECO:0000269|PubMed:11798174}.
Function -- GeneRIF ? help Back to Top
  1. Data suggest that DREB2C is a regulator of heat stress tolerance in Arabidopsis.
    [PMID: 17716623]
  2. identify possible targets of DREB2C transcription factors at the protein level
    [PMID: 19830397]
  3. Overexpression of DREB2C affects the expression of stress-responsive genes and affects ABA sensitivity.
    [PMID: 20395451]
  4. these results indicate that DREB2C and HsfA3 are key players in regulating the heat tolerance of Arabidopsis.
    [PMID: 20849812]
  5. These results suggest that DREB2C plays an important role in promoting oxidative stress tolerance in Arabidopsis.
    [PMID: 22286229]
  6. The TATA-proximal region and some latent trans-acting factors may cooperate in heat shock-induced activation of the Arabidopsis DREB2C promoter.
    [PMID: 22716647]
  7. We propose that AtCYS4 functions in thermotolerance under the control of the DREB2C cascade
    [PMID: 23868510]
  8. DREB2C functions as transcriptional activator that promotes NaCl tolerance, in part through upregulation of the stress-responsive gene COR15A.
    [PMID: 24737413]
  9. results suggest that DREB2C is a stress- and ABA-inducible gene that acts as a positive regulator of ABA biosynthesis in germinating seeds through activating NCED9 expression
    [PMID: 25150152]
  10. These results demonstrate that VOZ1 functions as a negative regulator of heat stress (HS)-inducible DREB2C signaling by blocking access to the AP2 DNA-binding domain of DREB2C.
    [PMID: 29536220]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By high-salt stress and abscisic acid (ABA) treatment. {ECO:0000269|PubMed:11798174}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid
Interaction ? help Back to Top
Source Intact With
BioGRIDAT3G19290, AT4G34000, AT1G45249
IntActSearch Q8LFR2
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT2G40340
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0265050.0BT026505.1 Arabidopsis thaliana At2g40340 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_565929.10.0Integrase-type DNA-binding superfamily protein
SwissprotQ8LFR20.0DRE2C_ARATH; Dehydration-responsive element-binding protein 2C
STRINGAT2G40340.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Wang ML, et al.
    A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07.
    Genome Res., 1999. 9(4): p. 325-33
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  3. Sakuma Y, et al.
    DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression.
    Biochem. Biophys. Res. Commun., 2002. 290(3): p. 998-1009
  4. Brown RL,Kazan K,McGrath KC,Maclean DJ,Manners JM
    A role for the GCC-box in jasmonate-mediated activation of the PDF1.2 gene of Arabidopsis.
    Plant Physiol., 2003. 132(2): p. 1020-32
  5. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  6. Lim CJ, et al.
    Gene expression profiles during heat acclimation in Arabidopsis thaliana suspension-culture cells.
    J. Plant Res., 2006. 119(4): p. 373-83
  7. Lim CJ, et al.
    Over-expression of the Arabidopsis DRE/CRT-binding transcription factor DREB2C enhances thermotolerance.
    Biochem. Biophys. Res. Commun., 2007. 362(2): p. 431-6
  8. Ramel F, et al.
    Genome-wide interacting effects of sucrose and herbicide-mediated stress in Arabidopsis thaliana: novel insights into atrazine toxicity and sucrose-induced tolerance.
    BMC Genomics, 2007. 8: p. 450
  9. Welling A,Palva ET
    Involvement of CBF transcription factors in winter hardiness in birch.
    Plant Physiol., 2008. 147(3): p. 1199-211
  10. Jaspers P, et al.
    Unequally redundant RCD1 and SRO1 mediate stress and developmental responses and interact with transcription factors.
    Plant J., 2009. 60(2): p. 268-79
  11. Lee K, et al.
    Identification of potential DREB2C targets in Arabidopsis thaliana plants overexpressing DREB2C using proteomic analysis.
    Mol. Cells, 2009. 28(4): p. 383-8
  12. Lee SJ, et al.
    DREB2C interacts with ABF2, a bZIP protein regulating abscisic acid-responsive gene expression, and its overexpression affects abscisic acid sensitivity.
    Plant Physiol., 2010. 153(2): p. 716-27
  13. Chen H, et al.
    Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat stress response.
    Biochem. Biophys. Res. Commun., 2010. 401(2): p. 238-44
  14. Vainonen JP, et al.
    RCD1-DREB2A interaction in leaf senescence and stress responses in Arabidopsis thaliana.
    Biochem. J., 2012. 442(3): p. 573-81
  15. Hwang JE, et al.
    Overexpression of Arabidopsis dehydration- responsive element-binding protein 2C confers tolerance to oxidative stress.
    Mol. Cells, 2012. 33(2): p. 135-40
  16. Chen H,Je J,Song C,Hwang JE,Lim CO
    A proximal promoter region of Arabidopsis DREB2C confers tissue-specific expression under heat stress.
    J Integr Plant Biol, 2012. 54(9): p. 640-51
  17. Je J,Song C,Hwang JE,Chung WS,Lim CO
    DREB2C acts as a transcriptional activator of the thermo tolerance-related phytocystatin 4 (AtCYS4) gene.
    Transgenic Res., 2014. 23(1): p. 109-23
  18. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
  19. Song C,Je J,Hong JK,Lim CO
    Ectopic expression of an Arabidopsis dehydration-responsive element-binding factor DREB2C improves salt stress tolerance in crucifers.
    Plant Cell Rep., 2014. 33(8): p. 1239-54
  20. Je J,Chen H,Song C,Lim CO
    Arabidopsis DREB2C modulates ABA biosynthesis during germination.
    Biochem. Biophys. Res. Commun., 2014. 452(1): p. 91-8
  21. Sazegari S,Niazi A,Ahmadi FS
    A study on the regulatory network with promoter analysis for Arabidopsis DREB-genes.
    Bioinformation, 2015. 11(2): p. 101-6
  22. Huang KC,Lin WC,Cheng WH
    Salt hypersensitive mutant 9, a nucleolar APUM23 protein, is essential for salt sensitivity in association with the ABA signaling pathway in Arabidopsis.
    BMC Plant Biol., 2018. 18(1): p. 40
  23. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448