PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G78080.1
Common NameAtWIND1, ERF059, F28K19.29, RAP2-4, RAP2.4, T11I11.1, WIND1
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 334aa    MW: 36609.9 Da    PI: 7.0703
Description related to AP2 4
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G78080.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2   2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                   y+GVr+++ +g+WvAeIr p++   r+r +lg+f+taeeAa a+++a+ kl+g
                  59******9.**********955...5*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000181.00E-33150210No hitNo description
SMARTSM003801.0E-37151214IPR001471AP2/ERF domain
PROSITE profilePS5103223.169151208IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.104.3E-32151209IPR001471AP2/ERF domain
SuperFamilySSF541712.68E-23151209IPR016177DNA-binding domain
PfamPF008472.2E-14152200IPR001471AP2/ERF domain
PRINTSPR003673.1E-11152163IPR001471AP2/ERF domain
PRINTSPR003673.1E-11174190IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009409Biological Processresponse to cold
GO:0009414Biological Processresponse to water deprivation
GO:0009611Biological Processresponse to wounding
GO:0009736Biological Processcytokinin-activated signaling pathway
GO:0009873Biological Processethylene-activated signaling pathway
GO:0010017Biological Processred or far-red light signaling pathway
GO:0045595Biological Processregulation of cell differentiation
GO:0071472Biological Processcellular response to salt stress
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
GO:0043565Molecular Functionsequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000014anatomyrosette leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 334 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.255240.0bud| flower| leaf| root| seed| silique| vegetative tissue
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT1G78080-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Mostly expressed in roots and leaves. Also detected in flowers and stems. {ECO:0000269|PubMed:9192694}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a member of the DREB subfamily A-6 of ERF/AP2 transcription factor family (RAP2.4). The protein contains one AP2 domain. Role in mediating light and ethylene signaling.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. BPM1-RAP2.4 interaction requires a complete MATH domain and the N-terminal region of RAP2.4.
    [PMID: 19843165]
  2. Rap2.4f is a positive regulator of senescence, promoting both developmental and dark-induced leaf senescence.
    [PMID: 20953945]
  3. The AP2/ERF transcription factor WIND1 controls cell dedifferentiation in Arabidopsis. [WIND1] [WOUND INDUCED DEDIFFERENTIATION 1]
    [PMID: 21396822]
  4. WIND1 is induced by wounding and promotes cell dedifferentiation. WIND proteins are required to activate the local cytokinin response at the wound site.
    [PMID: 22112447]
  5. the WIND1-mediated signaling cascade to promote cell dedifferentiation might be conserved in at least several species of Brassicaceae and Solanaceae.
    [PMID: 24389814]
  6. WIND1 directly binds the ESR1 promoter and activates tts expression.
    [PMID: 28011694]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- Hormone ? help Back to Top
Source Hormone
Interaction ? help Back to Top
Source Intact With
IntActSearch Q8H1E4
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G78080
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0092430.0AC009243.3 Genomic sequence for Arabidopsis thaliana BAC F28K19 from chromosome I, complete sequence.
GenBankAY1504680.0AY150468.1 Arabidopsis thaliana putative AP2 domain containing protein (At1g78080) mRNA, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_177931.10.0related to AP2 4
SwissprotQ8H1E40.0RAP24_ARATH; Ethylene-responsive transcription factor RAP2-4
STRINGAT1G78080.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. P
    New molecular phenotypes in the dst mutants of Arabidopsis revealed by DNA microarray analysis.
    Plant Cell, 2001. 13(12): p. 2703-17
  3. Ekman DR,Lorenz WW,Przybyla AE,Wolfe NL,Dean JF
    SAGE analysis of transcriptome responses in Arabidopsis roots exposed to 2,4,6-trinitrotoluene.
    Plant Physiol., 2003. 133(3): p. 1397-406
  4. Dal Bosco C, et al.
    Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.
    J. Biol. Chem., 2004. 279(2): p. 1060-9
  5. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  6. Gepstein S, et al.
    Large-scale identification of leaf senescence-associated genes.
    Plant J., 2003. 36(5): p. 629-42
  7. Kasukabe Y, et al.
    Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stress-regulated genes in transgenic Arabidopsis thaliana.
    Plant Cell Physiol., 2004. 45(6): p. 712-22
  8. Souret FF,Kastenmayer JP,Green PJ
    AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets.
    Mol. Cell, 2004. 15(2): p. 173-83
  9. Iwase A,Ishii H,Aoyagi H,Ohme-Takagi M,Tanaka H
    Comparative analyses of the gene expression profiles of Arabidopsis intact plant and cultured cells.
    Biotechnol. Lett., 2005. 27(15): p. 1097-103
  10. Kim S,Soltis PS,Wall K,Soltis DE
    Phylogeny and domain evolution in the APETALA2-like gene family.
    Mol. Biol. Evol., 2006. 23(1): p. 107-20
  11. McGrath KC, et al.
    Repressor- and activator-type ethylene response factors functioning in jasmonate signaling and disease resistance identified via a genome-wide screen of Arabidopsis transcription factor gene expression.
    Plant Physiol., 2005. 139(2): p. 949-59
  12. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  13. Pischke MS,Huttlin EL,Hegeman AD,Sussman MR
    A transcriptome-based characterization of habituation in plant tissue culture.
    Plant Physiol., 2006. 140(4): p. 1255-78
  14. Xiong Y,Fei SZ
    Functional and phylogenetic analysis of a DREB/CBF-like gene in perennial ryegrass (Lolium perenne L.).
    Planta, 2006. 224(4): p. 878-88
  15. Pati A,Vasquez-Robinet C,Heath LS,Grene R,Murali TM
    XcisClique: analysis of regulatory bicliques.
    BMC Bioinformatics, 2006. 7: p. 218
  16. Jung J, et al.
    The barley ERF-type transcription factor HvRAF confers enhanced pathogen resistance and salt tolerance in Arabidopsis.
    Planta, 2007. 225(3): p. 575-88
  17. Catala R, et al.
    The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses.
    Plant Cell, 2007. 19(9): p. 2952-66
  18. Shaikhali J, et al.
    The redox-sensitive transcription factor Rap2.4a controls nuclear expression of 2-Cys peroxiredoxin A and other chloroplast antioxidant enzymes.
    BMC Plant Biol., 2008. 8: p. 48
  19. Welling A,Palva ET
    Involvement of CBF transcription factors in winter hardiness in birch.
    Plant Physiol., 2008. 147(3): p. 1199-211
  20. Kim JM, et al.
    Alterations of lysine modifications on the histone H3 N-tail under drought stress conditions in Arabidopsis thaliana.
    Plant Cell Physiol., 2008. 49(10): p. 1580-8
  21. Weber H,Hellmann H
    Arabidopsis thaliana BTB/ POZ-MATH proteins interact with members of the ERF/AP2 transcription factor family.
    FEBS J., 2009. 276(22): p. 6624-35
  22. Lin RC,Park HJ,Wang HY
    Role of Arabidopsis RAP2.4 in regulating light- and ethylene-mediated developmental processes and drought stress tolerance.
    Mol Plant, 2008. 1(1): p. 42-57
  23. Xu H,Wang X,Chen J
    Overexpression of the Rap2.4f transcriptional factor in Arabidopsis promotes leaf senescence.
    Sci China Life Sci, 2010. 53(10): p. 1221-6
  24. Iwase A, et al.
    The AP2/ERF transcription factor WIND1 controls cell dedifferentiation in Arabidopsis.
    Curr. Biol., 2011. 21(6): p. 508-14
  25. Rae L,Lao NT,Kavanagh TA
    Regulation of multiple aquaporin genes in Arabidopsis by a pair of recently duplicated DREB transcription factors.
    Planta, 2011. 234(3): p. 429-44
  26. Iwase A,Ohme-Takagi M,Sugimoto K
    WIND1: a key molecular switch for plant cell dedifferentiation.
    Plant Signal Behav, 2011. 6(12): p. 1943-5
  27. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
  28. Iwase A, et al.
    Arabidopsis WIND1 induces callus formation in rapeseed, tomato, and tobacco.
    Plant Signal Behav, 2013. 8(12): p. e27432
  29. Hiltscher H, et al.
    The radical induced cell death protein 1 (RCD1) supports transcriptional activation of genes for chloroplast antioxidant enzymes.
    Front Plant Sci, 2014. 5: p. 475
  30. Iwase A, et al.
    WIND1-based acquisition of regeneration competency in Arabidopsis and rapeseed.
    J. Plant Res., 2015. 128(3): p. 389-97
  31. Ikeuchi M, et al.
    PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis.
    Nat Plants, 2015. 1: p. 15089
  32. Iwase A, et al.
    WIND1 Promotes Shoot Regeneration through Transcriptional Activation of ENHANCER OF SHOOT REGENERATION1 in Arabidopsis.
    Plant Cell, 2017. 29(1): p. 54-69
  33. Okamuro JK,Caster B,Villarroel R,Van Montagu M,Jofuku KD
    The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 1997. 94(13): p. 7076-81