PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G72360.1
Common NameAtERF73, ERF073, ERF73, HRE1, T10D10.17
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 211aa    MW: 23661.2 Da    PI: 4.5542
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G72360.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2  1 sgykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkklege 56
                 s+ykG+r+++ +grW+AeIrdp     +  r++lg+f taeeAa+a++  +k+++g+
                 79********.**********72....46*************************985 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541719.81E-232382IPR016177DNA-binding domain
CDDcd000183.55E-332382No hitNo description
PfamPF008471.5E-132373IPR001471AP2/ERF domain
SMARTSM003806.6E-372487IPR001471AP2/ERF domain
PROSITE profilePS5103224.1442481IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.109.9E-312482IPR001471AP2/ERF domain
PRINTSPR003673.8E-112536IPR001471AP2/ERF domain
PRINTSPR003673.8E-114763IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009873Biological Processethylene-activated signaling pathway
GO:0034059Biological Processresponse to anoxia
GO:0071456Biological Processcellular response to hypoxia
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0009025anatomyvascular leaf
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 211 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5wx9_A2e-2121831174Ethylene-responsive transcription factor ERF096
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
No. Start End Sequence
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT1G72360-
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the ERF (ethylene response factor) subfamily B-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 5 members in this subfamily including RAP2.2 AND RAP2.12.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. rotein localized in the nucleus and functioned as an in vivo transcription activator as confirmed in transient assays and experiments.
    [PMID: 15980186]
  2. HRE1 and HRE2 encode two nuclear-localized ethylene response factors specifically up-regulated under low oxygen conditions.
    [PMID: 20113439]
  3. AtERF73/HRE1 is involved in modulating ethylene responses under both normoxia and hypoxia.
    [PMID: 21398256]
  4. controlled by 3 pathways during hypoxia: an ethylene-dependent pathway, an ethylene-independent/H 2O 2-dependent pathway, and an ethylene and H 2O 2-independent pathway
    [PMID: 24698791]
  5. HRE1alpha functions as a transcription activator in the nucleus, and plays an important role in root development through regulation of root meristem cell division.
    [PMID: 24728113]
  6. AtERF73/HRE1 plays a role in H2O2 production by affecting the hypoxia-induced expression of Rboh genes in hypoxia signal transduction.
    [PMID: 27995331]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- Hormone ? help Back to Top
Source Hormone
Interaction ? help Back to Top
Source Intact With
IntActSearch Q8H0T5
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G72360
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0165290.0AC016529.7 Arabidopsis thaliana chromosome 1 BAC T10D10 genomic sequence, complete sequence.
GenBankBT0020630.0BT002063.1 Arabidopsis thaliana putative AP2 domain transcription factor (At1g72360) mRNA, complete cds.
GenBankBT0062590.0BT006259.1 Arabidopsis thaliana At1g72360 mRNA, complete cds.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_177380.21e-156Integrase-type DNA-binding superfamily protein
SwissprotQ8H0T51e-157ERF73_ARATH; Ethylene-responsive transcription factor ERF073
TrEMBLA0A178W8F11e-144A0A178W8F1_ARATH; HRE1
TrEMBLF4IDA71e-144F4IDA7_ARATH; Integrase-type DNA-binding superfamily protein
STRINGAT1G72360.21e-145(Arabidopsis thaliana)
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  3. Shin R,Schachtman DP
    Hydrogen peroxide mediates plant root cell response to nutrient deprivation.
    Proc. Natl. Acad. Sci. U.S.A., 2004. 101(23): p. 8827-32
  4. Sahr T,Voigt G,Paretzke HG,Schramel P,Ernst D
    Caesium-affected gene expression in Arabidopsis thaliana.
    New Phytol., 2005. 165(3): p. 747-54
  5. Nawy T, et al.
    Transcriptional profile of the Arabidopsis root quiescent center.
    Plant Cell, 2005. 17(7): p. 1908-25
  6. Ogawa T, et al.
    Functional analysis of Arabidopsis ethylene-responsive element binding protein conferring resistance to Bax and abiotic stress-induced plant cell death.
    Plant Physiol., 2005. 138(3): p. 1436-45
  7. Nakayama N, et al.
    Gene trap lines define domains of gene regulation in Arabidopsis petals and stamens.
    Plant Cell, 2005. 17(9): p. 2486-506
  8. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  9. Licausi F, et al.
    HRE1 and HRE2, two hypoxia-inducible ethylene response factors, affect anaerobic responses in Arabidopsis thaliana.
    Plant J., 2010. 62(2): p. 302-15
  10. Licausi F, et al.
    Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability.
    New Phytol., 2011. 190(2): p. 442-56
  11. Yang CY,Hsu FC,Li JP,Wang NN,Shih MC
    The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis.
    Plant Physiol., 2011. 156(1): p. 202-12
  12. Hess N,Klode M,Anders M,Sauter M
    The hypoxia responsive transcription factor genes ERF71/HRE2 and ERF73/HRE1 of Arabidopsis are differentially regulated by ethylene.
    Physiol Plant, 2011. 143(1): p. 41-9
  13. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
  14. Gibbs DJ, et al.
    Homeostatic response to hypoxia is regulated by the N-end rule pathway in plants.
    Nature, 2011. 479(7373): p. 415-8
  15. Yang CY
    Ethylene and hydrogen peroxide are involved in hypoxia signaling that modulates AtERF73/HRE1 expression.
    Plant Signal Behav, 2014. 9(3): p. e28583
  16. Seok HY,Tarte VN,Lee SY,Park HY,Moon YH
    Arabidopsis HRE1α, a splicing variant of AtERF73/HRE1, functions as a nuclear transcription activator in hypoxia response and root development.
    Plant Cell Rep., 2014. 33(8): p. 1255-62
  17. Yang CY,Huang YC,Ou SL
    ERF73/HRE1 is involved in H2O2 production via hypoxia-inducible Rboh gene expression in hypoxia signaling.
    Protoplasma, 2017. 254(4): p. 1705-1714
  18. Riechmann JL,Meyerowitz EM
    The AP2/EREBP family of plant transcription factors.
    Biol. Chem., 1998. 379(6): p. 633-46