PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G67260.1
Common NameF1N21.8, TCP1
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family TCP
Protein Properties Length: 359aa    MW: 40754.4 Da    PI: 5.0871
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G67260.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgt...ssssa...sec.......eaesssssasnss 86 
                   +kkdrhski T++g RdRRvRls+ +a++fFdLqd+LGfdk+skt++WLl+++ +aike ++    +   +     +       e+e+++++++n  
                  589*************************************************************5552...42321.2344433244444444443.. PP

          TCP  87 sg..............kaaksaakskksqksaasalnlak.esrakarararertrekmriknk 135
                   g              ++   +a++   +k++++ +n++     akar +a+ert+e m+ +n 
                  .1345889999999985555555555555555556777664677***************98865 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF036341.9E-3787234IPR005333Transcription factor, TCP
PROSITE profilePS5136934.21887145IPR017887Transcription factor TCP subgroup
PROSITE profilePS513708.677216233IPR017888CYC/TB1, R domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009908Biological Processflower development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000229anatomyflower meristem
PO:0007601developmental stagefloral organ meristem development stage
PO:0007602developmental stagefloral organ primordium development stage
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5zkt_A1e-1392145154Putative transcription factor PCF6
5zkt_B1e-1392145154Putative transcription factor PCF6
Search in ModeBase
Expression -- Microarray ? help Back to Top
Source ID
Expression AtlasAT1G67260
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed transiently in early stages of floral meristems development but continuously in axillary shoot meristems, specifically in the dorsal part (adaxial). {ECO:0000269|PubMed:11470410}.
UniprotTISSUE SPECIFICITY: Axillary shoot and floral meristems. {ECO:0000269|PubMed:11470410}.
Functional Description ? help Back to Top
Source Description
TAIREncodes protein with TCP (TB1,CYC,PCF) domain which is likely to be involved in DNA binding and protein-protein interactions. Based on genome analysis, there is a 9-member gene family that possesses this domain in Arabidopsis. Orthologue of Antirrhinum gene CYCLOIDEA.
UniProtInvolved in petal morphogenesis. {ECO:0000269|PubMed:17940055}.
Function -- GeneRIF ? help Back to Top
  1. TCP1 positively regulates the expression of the key brassinosteroid biosynthetic gene, DWF4.
    [PMID: 20435901]
  2. important roles of Arabidopsis TCP1 in the longitudinal elongation of petioles, rosette leaves and inflorescent stems
    [PMID: 20944404]
  3. TCP1 positively regulates BR biosynthesis via its direct regulation of the transcription of DWF4.
    [PMID: 21822059]
  4. Data indicate that transcription factors TCP-NGA regulatory interaction is likely conserved in angiosperms, including important crop species.
    [PMID: 25625546]
  5. TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis thaliana
    [PMID: 26233893]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT3G50660(A)
Regulation -- Hormone ? help Back to Top
Source Hormone
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G67260
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC0021300.0AC002130.2 Genomic sequence for Arabidopsis thaliana BAC F1N21 from chromosome I, complete sequence.
GenBankCP0026840.0CP002684.1 Arabidopsis thaliana chromosome 1 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001077781.10.0TCP family transcription factor
SwissprotQ9FYG70.0TCP1_ARATH; Transcription factor TCP1
TrEMBLF4HRT70.0F4HRT7_ARATH; TCP family transcription factor
STRINGAT1G67260.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP18015163
Publications ? help Back to Top
  1. Cubas P,Lauter N,Doebley J,Coen E
    The TCP domain: a motif found in proteins regulating plant growth and development.
    Plant J., 1999. 18(2): p. 215-22
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  3. Cubas P,Coen E,Zapater JM
    Ancient asymmetries in the evolution of flowers.
    Curr. Biol., 2001. 11(13): p. 1050-2
  4. Citerne HL,Luo D,Pennington RT,Coen E,Cronk QC
    A phylogenomic investigation of CYCLOIDEA-like TCP genes in the Leguminosae.
    Plant Physiol., 2003. 131(3): p. 1042-53
  5. Damerval C,Le Guilloux M,Jager M,Charon C
    Diversity and evolution of CYCLOIDEA-like TCP genes in relation to flower development in Papaveraceae.
    Plant Physiol., 2007. 143(2): p. 759-72
  6. Aguilar-Martínez JA,Poza-Carrión C,Cubas P
    Arabidopsis BRANCHED1 acts as an integrator of branching signals within axillary buds.
    Plant Cell, 2007. 19(2): p. 458-72
  7. Finlayson SA
    Arabidopsis Teosinte Branched1-like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1.
    Plant Cell Physiol., 2007. 48(5): p. 667-77
  8. Busch A,Zachgo S
    Control of corolla monosymmetry in the Brassicaceae Iberis amara.
    Proc. Natl. Acad. Sci. U.S.A., 2007. 104(42): p. 16714-9
  9. Guo Z, et al.
    TCP1 modulates brassinosteroid biosynthesis by regulating the expression of the key biosynthetic gene DWARF4 in Arabidopsis thaliana.
    Plant Cell, 2010. 22(4): p. 1161-73
  10. Koyama T,Sato F,Ohme-Takagi M
    A role of TCP1 in the longitudinal elongation of leaves in Arabidopsis.
    Biosci. Biotechnol. Biochem., 2010. 74(10): p. 2145-7
  11. An J,Guo Z,Gou X,Li J
    TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana.
    Plant Signal Behav, 2011. 6(8): p. 1117-8
  12. Yang X, et al.
    Evolution of double positive autoregulatory feedback loops in CYCLOIDEA2 clade genes is associated with the origin of floral zygomorphy.
    Plant Cell, 2012. 24(5): p. 1834-47
  13. Meinke DW
    A survey of dominant mutations in Arabidopsis thaliana.
    Trends Plant Sci., 2013. 18(2): p. 84-91
  14. Efroni I, et al.
    Regulation of leaf maturation by chromatin-mediated modulation of cytokinin responses.
    Dev. Cell, 2013. 24(4): p. 438-45
  15. Mar
    Large-scale identification of gibberellin-related transcription factors defines group VII ETHYLENE RESPONSE FACTORS as functional DELLA partners.
    Plant Physiol., 2014. 166(2): p. 1022-32
  16. Chen GH,Sun JY,Liu M,Liu J,Yang WC
    SPOROCYTELESS is a novel embryophyte-specific transcription repressor that interacts with TPL and TCP proteins in Arabidopsis.
    J Genet Genomics, 2014. 41(12): p. 617-25
  17. Ballester P,Navarrete-G
    Leaf expansion in Arabidopsis is controlled by a TCP-NGA regulatory module likely conserved in distantly related species.
    Physiol Plant, 2015. 155(1): p. 21-32
  18. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
  19. Gao Y,Zhang D,Li J
    TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis thaliana.
    J Genet Genomics, 2015. 42(7): p. 383-92
  20. Mazur MJ, et al.
    Arabidopsis TCP Transcription Factors Interact with the SUMO Conjugating Machinery in Nuclear Foci.
    Front Plant Sci, 2017. 8: p. 2043