PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT1G25580.1

Common Name

ANAC008, F14G11.2, F2J7.1, NAC008, SOG1

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

NAC

Protein Properties

Length: 449aa MW: 50288.8 Da PI: 4.6895

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT1G25580.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	101.7	1e-31	58	192	1	128
NAM 1 lppGfrFhPtdeelvveyLkkk.vegkk....leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk.....sgyWk 84 lp+G++F+P+d e++++ L+k+ ++g + ++ e+i++v+ i++++P++Lp vk++ + +fF+k+ k+y+tg+rk+r+++ + +W+ AT1G25580.1 58 LPRGVKFDPSDPEIIWHLLAKSgLSGLSshpfID--EFIPTVNqddgICYTHPKNLP-GVKSDGTVSHFFHKAIKAYSTGTRKRRKIHdddfgDVRWH 152 799**********9999988444444644422..33444433345******.778888999**************86555655889 PP NAM 85 atgkdkevlskkgelvglkktLvfykgrapkgektdWvmheyrl 128 +tg++k+v+ +g + g+kk++v+y g+a kt+Wvmh+y+l AT1G25580.1 153 KTGRTKPVVL-DGVQRGCKKIMVLYGGKAV---KTNWVMHQYHL 192 ********.99********76665...6******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.02E-37	43	211	IPR003441	NAC domain
PROSITE profile	PS51005	31.083	58	211	IPR003441	NAC domain
Pfam	PF02365	1.5E-12	59	192	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000077	Biological Process	DNA damage checkpoint
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007275	Biological Process	multicellular organism development
GO:0010332	Biological Process	response to gamma radiation
GO:0040020	Biological Process	regulation of meiotic nuclear division
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000084	anatomy	plant sperm cell
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 449 aa Download sequence Send to blast
MAGRSWLIDS NRIATKIMSA SASSDPRQVV WKSNPSRHCP KCQHVIDNSD VVDDWPGLPR 60 GVKFDPSDPE IIWHLLAKSG LSGLSSHPFI DEFIPTVNQD DGICYTHPKN LPGVKSDGTV 120 SHFFHKAIKA YSTGTRKRRK IHDDDFGDVR WHKTGRTKPV VLDGVQRGCK KIMVLYGGKA 180 VKTNWVMHQY HLGIEEDEKE GDYVVSKIFY QQPQQLVVKR GDKAEQEVSE DIFAAVTPTA 240 DPVTPKLATP EPRNAVRICS DSHIASDYVT PSDYVSAHEV SLAETSEVMC MEDEVQSIQP 300 NHERPSSGPE LEHGLENGAK EMLDDKEEQE KDRDNENQGE EDPTWFDSGS QFILNSQQLV 360 EALSLCDDLL GSQDREENTN SGSLKDKQPC IADYAHLGPE DFKRDLEECQ KIVLDPSNIE 420 LDTPPEFRLS QLEFGSQDSF LAWGTGKTD

Sequence ? help Back to Top

Protein Sequence Length: 449 aa Download sequence Send to blast

MAGRSWLIDS NRIATKIMSA SASSDPRQVV WKSNPSRHCP KCQHVIDNSD VVDDWPGLPR  60
GVKFDPSDPE IIWHLLAKSG LSGLSSHPFI DEFIPTVNQD DGICYTHPKN LPGVKSDGTV  120
SHFFHKAIKA YSTGTRKRRK IHDDDFGDVR WHKTGRTKPV VLDGVQRGCK KIMVLYGGKA  180
VKTNWVMHQY HLGIEEDEKE GDYVVSKIFY QQPQQLVVKR GDKAEQEVSE DIFAAVTPTA  240
DPVTPKLATP EPRNAVRICS DSHIASDYVT PSDYVSAHEV SLAETSEVMC MEDEVQSIQP  300
NHERPSSGPE LEHGLENGAK EMLDDKEEQE KDRDNENQGE EDPTWFDSGS QFILNSQQLV  360
EALSLCDDLL GSQDREENTN SGSLKDKQPC IADYAHLGPE DFKRDLEECQ KIVLDPSNIE  420
LDTPPEFRLS QLEFGSQDSF LAWGTGKTD

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.41316	0.0	floral meristem\| root

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30689292	0.0
Genevisible	255739_at	0.0
Expression Atlas	AT1G25580	-
AtGenExpress	AT1G25580	-
ATTED-II	AT1G25580	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in shoot and root apical meristems, in lateral root primordia, in the vasculature of young leaves and in the root stele. {ECO:0000269\|PubMed:23907539}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes suppressor of gamma response 1 (SOG1), a putative transcription factor governing multiple responses to DNA damage.
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Function -- GeneRIF ? help Back to Top
Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction. [PMID: 21613568] SOG1 is a central transcriptional regulator of the DNA damage response. [PMID: 24736489] SOG1 function together with ATR and ALT2 to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure. [PMID: 26320227] Observations indicate that SOG1 plays an important role in regulating more than 100 genes to activate the DNA damage response. [review] [PMID: 26617076] These results show that the extent of ser-gln phosphorylation in SOG1 regulates gene expression levels and determines the strength of DNA damage responses. [PMID: 29208704] identification of target genes and possible role in plant immunity [PMID: 29430765]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT1G25580.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT1G25580

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK221266	0.0	AK221266.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL24-13-I20.
GenBank	AK228316	0.0	AK228316.1 Arabidopsis thaliana mRNA for hypothetical protein, complete cds, clone: RAFL14-74-M01.
GenBank	BT010450	0.0	BT010450.1 Arabidopsis thaliana At1g25580 mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_564238.2	0.0	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein
Swissprot	Q6NQK2	0.0	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A178WLI1	0.0	A0A178WLI1_ARATH; SOG1
STRING	AT1G25580.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM9707	27	36
Representative plant	OGRP8264	10	16

Link Out ? help Back to Top
Phytozome	AT1G25580.1
Entrez Gene	839145
iHOP	AT1G25580
wikigenes	AT1G25580

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Preuss SB,Britt AB A DNA-damage-induced cell cycle checkpoint in Arabidopsis. Genetics, 2003. 164(1): p. 323-34 [PMID:12750343] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Ooka H, et al. Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana. DNA Res., 2003. 10(6): p. 239-47 [PMID:15029955] Ascencio-Ib Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. Plant Physiol., 2008. 148(1): p. 436-54 [PMID:18650403] Yoshiyama K,Conklin PA,Huefner ND,Britt AB Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage. Proc. Natl. Acad. Sci. U.S.A., 2009. 106(31): p. 12843-8 [PMID:19549833] Furukawa T, et al. A shared DNA-damage-response pathway for induction of stem-cell death by UVB and by gamma irradiation. DNA Repair (Amst.), 2010. 9(9): p. 940-8 [PMID:20634150] Adachi S, et al. Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A., 2011. 108(24): p. 10004-9 [PMID:21613568] Yoshiyama KO, et al. ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis. EMBO Rep., 2013. 14(9): p. 817-22 [PMID:23907539] Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Yoshiyama KO,Kimura S,Maki H,Britt AB,Umeda M The role of SOG1, a plant-specific transcriptional regulator, in the DNA damage response. Plant Signal Behav, 2014. 9(4): p. e28889 [PMID:24736489] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]