PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Achn093071
Organism
Actinidia chinensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; Ericales; Actinidiaceae; Actinidia
Family TCP
Protein Properties Length: 814aa    MW: 87887.7 Da    PI: 6.5652
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Achn093071genomeIKGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1TCP112.17.8e-355436402101
         TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgtssssasec....eaesssssasnsssgkaaksaak 96 
                 a+++++++++hTkv+gR+RR+R++++caar+F+L++eLG+++d++t+ WLl+ a++ai+e+tgt++ +a ++    + + + ssa+n+s+g      ++
  Achn093071 543 AARRSSTKDRHTKVEGRGRRIRIPVTCAARIFQLTRELGHKSDGETVRWLLEHAEEAIIEATGTGTVPAIAVsvggTLKIRTSSANNESEG------PT 635
                 7899************************************************************888885554333111111122211111......12 PP

         TCP  97 skksq 101
                 +++++
  Achn093071 636 KRRRR 640
                 22222 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF011549.2E-835177IPR013528Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
TIGRFAMsTIGR018331.9E-2195452IPR010122Hydroxymethylglutaryl-CoA synthase, eukaryotic
Gene3DG3DSA:3.40.47.101.7E-1056269IPR016039Thiolase-like
SuperFamilySSF539016.08E-337175IPR016039Thiolase-like
CDDcd008273.00E-817371No hitNo description
PROSITE patternPS012260108123IPR000590Hydroxymethylglutaryl-coenzyme A synthase, active site
SuperFamilySSF539014.03E-65178265IPR016039Thiolase-like
PfamPF085403.2E-112178452IPR013746Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
SuperFamilySSF539014.03E-65303450IPR016039Thiolase-like
Gene3DG3DSA:3.40.47.103.0E-4325373IPR016039Thiolase-like
PfamPF036341.5E-28548634IPR005333Transcription factor, TCP
PROSITE profilePS5136926.297549603IPR017887Transcription factor TCP subgroup
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008299Biological Processisoprenoid biosynthetic process
GO:0005829Cellular Componentcytosol
GO:0009506Cellular Componentplasmodesma
GO:0004421Molecular Functionhydroxymethylglutaryl-CoA synthase activity
Sequence ? help Back to Top
Protein Sequence    Length: 814 aa     Download sequence    Send to blast
MASQPKNVGI LAMEIYFPPT CVQQEEMEVH DGASKGKYTI GLGQDCMAFC TDVEDVISMS  60
LTVVTSLLEK YGVDPAQIGR LEVGSETVID KSKSIKTFLM QIFEESGNTD IEGVDSTNAC  120
YGGTAALLNC VNWVESCSWD GRYGLVVCTD SAVYAEGPAR PTGGAAAIAM LIGPDAPIAF  180
ESKFRGSHMS HVYDFYKPNL ASEYPVVDGK LSQTCYLMAL DSCYKRFCHK YEKLEGKQFS  240
VVDADYFVFH SPYNKLVQKS FARLLFNDFS RNASSVDEAS KEKLAPFSTL TGDESYQSRD  300
LEKATQQVAK PFYDAKVKPA TLVPKQVGNM YTASLYAAFV SLIHNKHTSL AGQRVVMFSY  360
GSGLSATMFS FQIREGQHPF SLSNIATVMN VGGKMKSRHE FPPEKFVETM KLMEHRYGAK  420
DFVTSKDCSL LAPGTYYLTE VDSMYRRFYT KKAGTDTTNT GCENGSVAND HEFEPDDDGG  480
GSSDISTSTG PPESSTRPIF KKEPIDLEPG SPDPKPNNAN HPIGMMPLMQ MQVVPATMPV  540
ATAARRSSTK DRHTKVEGRG RRIRIPVTCA ARIFQLTREL GHKSDGETVR WLLEHAEEAI  600
IEATGTGTVP AIAVSVGGTL KIRTSSANNE SEGPTKRRRR ASNSEFYDVA AASDGVTQAA  660
GLAPVMPAAA PQGMVPIWSV SNAGMMIPSN AIWVIPPAAA ASPVAVTTGL NPPQFWTISP  720
SVTPVFNVTA RPISSLVSVA QPVTLVSPSV CGSLMTGETA VGGAAKAGAK KSSMAPASVS  780
SQAQILRDFS MEIYDKRELQ FMDQQTQSTP SKP*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2f82_A0.064522450HMG-CoA synthase
2f9a_A0.0645224503-Hydroxy-3-methylglutaryl coenzyme A synthase 1
2fa0_A0.064522450HMG-CoA synthase
2fa3_A0.064522450HMG-CoA synthase
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtThis enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation. {ECO:0000269|PubMed:20484369}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028063286.10.0hydroxymethylglutaryl-CoA synthase-like
SwissprotP548730.0HMCS_ARATH; Hydroxymethylglutaryl-CoA synthase
TrEMBLA0A2R6Q8A70.0A0A2R6Q8A7_ACTCH; 3-hydroxy-3-methylglutaryl coenzyme A synthase
STRINGEOY246020.0(Theobroma cacao)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G51910.23e-42TCP family protein
Publications ? help Back to Top
  1. Lange BM,Ghassemian M
    Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.
    Plant Mol. Biol., 2003. 51(6): p. 925-48
    [PMID:12777052]
  2. Nagegowda DA,Bach TJ,Chye ML
    Brassica juncea 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase 1: expression and characterization of recombinant wild-type and mutant enzymes.
    Biochem. J., 2004. 383(Pt. 3): p. 517-27
    [PMID:15233626]
  3. Bach TJ, et al.
    Aspects related to mevalonate biosynthesis in plants.
    Lipids, 1991. 26(8): p. 637-48
    [PMID:1685759]
  4. Ishiguro S, et al.
    The Arabidopsis FLAKY POLLEN1 gene encodes a 3-hydroxy-3-methylglutaryl-coenzyme A synthase required for development of tapetum-specific organelles and fertility of pollen grains.
    Plant Cell Physiol., 2010. 51(6): p. 896-911
    [PMID:20484369]
  5. Liao P, et al.
    Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway.
    Plant Cell Rep., 2014. 33(7): p. 1005-22
    [PMID:24682521]
  6. Weber T,Bach TJ
    Conversion of acetyl-coenzyme A into 3-hydroxy-3-methylglutaryl-coenzyme A in radish seedlings. Evidence of a single monomeric protein catalyzing a FeII/quinone-stimulated double condensation reaction.
    Biochim. Biophys. Acta, 1994. 1211(1): p. 85-96
    [PMID:8123686]
  7. Montamat F,Guilloton M,Karst F,Delrot S
    Isolation and characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
    Gene, 1995. 167(1-2): p. 197-201
    [PMID:8566777]