PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus

Family

E2F/DP

Protein Properties

Length: 303aa MW: 34204 Da PI: 6.2636

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
orange1.1g042344m	genome	ICGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	79.4	3.3e-25	74	154	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 r+eksL+lltq+f++l+ +s+ +++tl+evak L+ + +++k+RR+YDi+NVL+++nliek ++k+++rw g orange1.1g042344m 74 RREKSLGLLTQNFVRLFVCSNVDMITLDEVAKLLLGDahntsVMRTKVRRLYDIANVLSSMNLIEKthtadTRKPAFRWLG 154 689************************************999**********************99*****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	2.8E-24	69	156	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.3E-31	74	154	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	3.8E-20	76	154	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	5.44E-14	76	155	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 303 aa Download sequence Send to blast
MIGSRPEDAF TTLDGGNSAK VGQNRFTMFF FIFWGSDDED DDEDDDSSSN PNPGSQSDSL 60 NPRSAHKSSK NDSRREKSLG LLTQNFVRLF VCSNVDMITL DEVAKLLLGD AHNTSVMRTK 120 VRRLYDIANV LSSMNLIEKT HTADTRKPAF RWLGVNRLEI GLADSLNLDE SRKRTFGTDV 180 TNISFKRKRM DTSINGDISQ SIKMEKQMKV DDLVRVVDGS NSENYVNQGP RSYQFGPFAP 240 ESVPEVNTSK NNVKGAHDWE SLTSKYCPQY HNQALRDLFS HYMEAWQSWY TEVAGKTIRQ 300 IS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	1e-16	43	146	118	228	Transcription factor E2F8
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	171	188	RKRTFGTDVTNISFKRKR

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:18787127}.
Uniprot	TISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366}.

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024044442.1	0.0	E2F transcription factor-like E2FE
Swissprot	Q8LSZ4	3e-73	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A067G2W9	0.0	A0A067G2W9_CITSI; Uncharacterized protein
STRING	XP_006476685.1	0.0	(Citrus sinensis)
STRING	XP_006439729.1	0.0	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6304	27	43

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	6e-73	DP-E2F-like 1

Link Out ? help Back to Top
Phytozome	orange1.1g042344m

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]