PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus

Family

LSD

Protein Properties

Length: 231aa MW: 24997.3 Da PI: 8.5505

Description

LSD family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
orange1.1g026941m	genome	ICGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-LSD1	40.8	3.6e-13	67	91	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 C+gCr +L YPrGA++V+CalC+t+ orange1.1g026941m 67 CSGCRSVLLYPRGATNVCCALCNTI 91 ***********************97 PP
2	zf-LSD1	49.1	9e-16	106	130	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 CggCrtlL+Y+rGA+sVRC++C+tV orange1.1g026941m 106 CGGCRTLLMYTRGATSVRCSCCHTV 130 ************************9 PP
3	zf-LSD1	45.1	1.6e-14	144	168	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 Cg+Crt+L+YP GApsV+Ca+C+ V orange1.1g026941m 144 CGHCRTTLMYPHGAPSVKCAVCQYV 168 **********************987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
TIGRFAMs	TIGR01053	1.3E-12	64	94	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	3.9E-11	67	91	IPR005735	Zinc finger, LSD1-type
TIGRFAMs	TIGR01053	2.8E-17	103	132	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	3.9E-13	106	130	IPR005735	Zinc finger, LSD1-type
TIGRFAMs	TIGR01053	9.8E-13	141	171	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	2.0E-13	144	168	IPR005735	Zinc finger, LSD1-type

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000303	Biological Process	response to superoxide
GO:0001666	Biological Process	response to hypoxia
GO:0002240	Biological Process	response to molecule of oomycetes origin
GO:0009626	Biological Process	plant-type hypersensitive response
GO:0009862	Biological Process	systemic acquired resistance, salicylic acid mediated signaling pathway
GO:0010104	Biological Process	regulation of ethylene-activated signaling pathway
GO:0010310	Biological Process	regulation of hydrogen peroxide metabolic process
GO:0010602	Biological Process	regulation of 1-aminocyclopropane-1-carboxylate metabolic process
GO:0010618	Biological Process	aerenchyma formation
GO:0043069	Biological Process	negative regulation of programmed cell death
GO:0016021	Cellular Component	integral component of membrane

Sequence ? help Back to Top
Protein Sequence Length: 231 aa Download sequence Send to blast
MPLRGFHLIH NEIKKPNQTK QIKLSFFIFL FLFIYINHTI TQLSIDFDFS NDSILLSLQG 60 MQSQLVCSGC RSVLLYPRGA TNVCCALCNT ITSVPIPGME MAQLICGGCR TLLMYTRGAT 120 SVRCSCCHTV NLAPAPNQFA HIICGHCRTT LMYPHGAPSV KCAVCQYVTN VNMANARVPL 180 PANRPNGTAI PGTLPSTSMT QTVVVENPMS VDESGKLVSN VVVGVSTEKK *

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Csi.4600	0.0	fruit

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in cotyledons, roots, rosette leaves, stems, inflorescences and flowers. {ECO:0000269\|PubMed:20456049}.

Functional Description ? help Back to Top
Source	Description
UniProt	Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269\|PubMed:10550898, ECO:0000269\|PubMed:11595797, ECO:0000269\|PubMed:11844114, ECO:0000269\|PubMed:12732715, ECO:0000269\|PubMed:15347794, ECO:0000269\|PubMed:16957775, ECO:0000269\|PubMed:18055613, ECO:0000269\|PubMed:18790826, ECO:0000269\|PubMed:20456049, ECO:0000269\|PubMed:21097903}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By methyl viologen. {ECO:0000269\|PubMed:20456049}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006468389.2	1e-174	uncharacterized protein LOC102607006
Swissprot	P94077	9e-77	LSD1_ARATH; Protein LSD1
TrEMBL	A0A067GD78	1e-168	A0A067GD78_CITSI; Uncharacterized protein
STRING	XP_006468386.1	1e-120	(Citrus sinensis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM5345	26	50

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G20380.7	6e-79	LSD family protein

Link Out ? help Back to Top
Phytozome	orange1.1g026941m

Publications ? help Back to Top
Spedaletti V, et al. Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana. Biochemistry, 2008. 47(17): p. 4936-47 [PMID:18393445] Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties. Plant Cell Rep., 2016. 35(3): p. 527-39 [PMID:26754794] Czarnocka W, et al. The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator. Plant Cell Environ., 2017. 40(11): p. 2644-2662 [PMID:28555890] Bernacki MJ, et al. LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana. Physiol Plant, 2019. 165(2): p. 369-382 [PMID:30461017]