PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID orange1.1g015627m
Common NameCISIN_1g015627mg
Organism
Citrus sinensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family E2F/DP
Protein Properties Length: 404aa    MW: 44903 Da    PI: 4.4761
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
orange1.1g015627mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.52e-2778143171
            E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                        r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  orange1.1g015627m  78 RYDSSLGLLTKKFINLIKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 143
                        6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.1E-2975145IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-3478143IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.99E-1778141IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.9E-2480143IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.4E-30157259No hitNo description
PfamPF164218.2E-31159258IPR032198E2F transcription factor, CC-MB domain
CDDcd146605.80E-36159259No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 404 aa     Download sequence    Send to blast
MEDNEVETSE WVGSPGLTNI SNGPFHTPVS AKGGRVNNRS KGIKGNRSTP QTPVSNAGEK  60
ISYHLGSPSA LTPAGSCRYD SSLGLLTKKF INLIKHAEDG ILDLNKAAET LEVQKRRIYD  120
ITNVLEGIGL IEKKLKNRIR WKGLDNSIPG EVDADASILQ ADIDNLSMEE LRVDEQTREL  180
RERLRELIEN ENNRKWLFVT EEDIKNLHCF QNQTLIAIKA PQGTTLEVPD PDEAVDYPQR  240
RYRIILRSTM GPIDVYLVSR FEEKFEETNS VEPPASVPPV SSSDSNENQV KEIINVDRAG  300
NETEAQAQQA HQIYSDLNSS QEVVGGMMKI VPSDVDNDAD YWLLSDADVS ITDMWKTDSG  360
AEWDGVNMLH AEFGMSDACT PTPQTPPSRI TEVPSTDFNP IHR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-2473144274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024038058.10.0transcription factor E2FA isoform X1
SwissprotQ9FNY01e-152E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A067FTB60.0A0A067FTB6_CITSI; Uncharacterized protein
STRINGXP_006481568.10.0(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-139E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]