PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae; Fragaria

Family

E2F/DP

Protein Properties

Length: 333aa MW: 36714.8 Da PI: 9.8187

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
mrna03312.1-v1.0-hybrid	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	68.1	1.1e-21	23	90	1	71
E2F_TDP 1 rkeksLrlltqkflklleksee..givtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rk+ksL ll+++fl+l+++ + + l+++a++L v rRRiYDi+NVLe+++l+++k+kn ++wkg mrna03312.1-v1.0-hybrid 23 RKQKSLSLLCSNFLSLYNRDDGatVLIGLDDAASRL---GV--VRRRIYDIVNVLESVGLLSRKSKNTYTWKG 90 79**************9766456789****...99..9*************************98 PP
2	E2F_TDP	68.6	7.5e-22	120	203	2	71
E2F_TDP 2 keksLrlltqkflkllek..seegivtlnevakeLvse.......dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 +eksL ll+q+f+kl+ + se+++++l+e+ak L+ +++k+RRiYDi+NVL+++nliek + k+++rw g mrna03312.1-v1.0-hybrid 120 REKSLALLAQNFVKLFVCggSESKAISLDEAAKLLLGVgdaqnvfVMRTKVRRIYDIANVLSSVNLIEKthtadTGKPAYRWLG 203 79**********999987888********87788999*********************999*****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.1E-23	19	91	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.0E-26	23	90	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	8.4E-20	24	90	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	3.91E-14	25	91	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	8.5E-21	117	205	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.0E-24	119	203	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.5E-18	121	203	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.01E-12	121	204	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 333 aa Download sequence Send to blast
MASSAVDYPP ATTTTRRDTS YSRKQKSLSL LCSNFLSLYN RDDGATVLIG LDDAASRLGV 60 VRRRIYDIVN VLESVGLLSR KSKNTYTWKG FAAVPDALKE LQEEGLDLTP IPAPVDETKR 120 EKSLALLAQN FVKLFVCGGS ESKAISLDEA AKLLLGVGDA QNVFVMRTKV RRIYDIANVL 180 SSVNLIEKTH TADTGKPAYR WLGLNGRREG LDLNSEQGKK RSFGTDLTNV SCKKSKVAEK 240 AMRNQGEAEK CNSDGCGAKE SAKSYQFGPF APVAVPRGRN GVNINKVCWE TVGACYRPQY 300 QNQAMKELFS HYREAWKLWN SQVAEKNPIR SS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	1e-27	22	193	3	226	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	mrna03312.1-v1.0-hybrid

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011460987.1	0.0	PREDICTED: E2F transcription factor-like E2FE
Swissprot	Q8LSZ4	1e-103	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A2P6QBP7	0.0	A0A2P6QBP7_ROSCH; Putative transcription factor E2F-DP family
STRING	XP_008374484.1	1e-121	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3668	33	66

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	1e-93	DP-E2F-like 1

Link Out ? help Back to Top
Phytozome	mrna03312.1-v1.0-hybrid

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]