PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Fagaceae; Castanea

Family

NAC

Protein Properties

Length: 160aa MW: 18507.8 Da PI: 7.2139

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
maker-scaffold08188-augustus-gene-0.7-mRNA-1	genome	THGP	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	133.1	1.9e-41	9	137	1	127
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp..kkvkaeekewyfFsk 63 lp GfrF+Ptdeel+++yL+ k eg++ + +vi+ev+ y+++Pw+Lp +++++++++w+fF+k maker-scaffold08188-augustus-gene-0.7-mRNA-1 9 LPLGFRFSPTDEELINHYLRLKNEGHDSGV-QVIAEVNFYEFDPWELPdlSAIESSNEQWFFFCK 72 699**********************988.99**********96448888999**9 PP NAM 64 rdkkyatgkrknratksgyWkatgkdkevlsk.....kgelvglkktLvfykgrapkgektdWvm 123 + + ++ nratksgyWkatgk+++++s+ +++l+g+kktLv+++g++pkg++++Wv+ maker-scaffold08188-augustus-gene-0.7-mRNA-1 73 LKIA----SHFNRATKSGYWKATGKERHITSRkwgpsNSSLIGIKKTLVYHTGHDPKGKRSNWVV 133 9776....479****************9999988899******************** PP NAM 124 heyr 127 +ey+ maker-scaffold08188-augustus-gene-0.7-mRNA-1 134 NEYH 137 *8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.28E-42	5	143	IPR003441	NAC domain
PROSITE profile	PS51005	41.22	9	160	IPR003441	NAC domain
Pfam	PF02365	4.7E-24	10	137	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 160 aa Download sequence Send to blast
MANLSLESLP LGFRFSPTDE ELINHYLRLK NEGHDSGVQV IAEVNFYEFD PWELPDLSAI 60 ESSNEQWFFF CKLKIASHFN RATKSGYWKA TGKERHITSR KWGPSNSSLI GIKKTLVYHT 120 GHDPKGKRSN WVVNEYHDIA TRQVCFLEKQ NFSLESQEIA

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3swm_A	1e-33	4	139	15	146	NAC domain-containing protein 19
3swm_B	1e-33	4	139	15	146	NAC domain-containing protein 19
3swm_C	1e-33	4	139	15	146	NAC domain-containing protein 19
3swm_D	1e-33	4	139	15	146	NAC domain-containing protein 19
3swp_A	1e-33	4	139	15	146	NAC domain-containing protein 19
3swp_B	1e-33	4	139	15	146	NAC domain-containing protein 19
3swp_C	1e-33	4	139	15	146	NAC domain-containing protein 19
3swp_D	1e-33	4	139	15	146	NAC domain-containing protein 19
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator essential for the anti-viral defense called virus basal resistance response pathway (PubMed:11041886, PubMed:15629774, PubMed:18785827, PubMed:24418554). Not involved in HRT-mediated hypersensitive response (HR) and resistance to TCV (PubMed:18785827). Binds DNA non specifically (PubMed:15629774). Activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). {ECO:0000250\|UniProtKB:Q9SCK6, ECO:0000269\|PubMed:11041886, ECO:0000269\|PubMed:15629774, ECO:0000269\|PubMed:18785827, ECO:0000269\|PubMed:24418554}.; FUNCTION: (Microbial infection) Compromised function in defense response pathway when interacting with the invading viral capsid protein (CP) of turnip crinkle virus (TCV) due to abnormal subcellular localization. {ECO:0000269\|PubMed:11041886, ECO:0000269\|PubMed:15629774}.
UniProt	Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (PubMed:18443413, PubMed:24329768). Calmodulin-regulated transcriptional repressor. Binds several synthetic promoters with randomly selected binding sites (PubMed:17947243). Functions synergistically with SNI1 as negative regulator of pathogen-induced PR1 expression and basal resistance to a virulent strain of P.syringae. Binds directly to the promoter of the PR1 gene (PubMed:22826500). Acts as positive regulator of innate immunity. Involved in the effector-triggered immunity (ETI) induction of immunity-related gene expression (PubMed:24329768). Mediates osmotic stress signaling in leaf senescence by up-regulating senescence-associated genes (PubMed:18443413). {ECO:0000269\|PubMed:17947243, ECO:0000269\|PubMed:18443413, ECO:0000269\|PubMed:22826500, ECO:0000269\|PubMed:24329768}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by bacterial pathogens type III effector proteins (TTEs). {ECO:0000269\|PubMed:16553893}.; INDUCTION: (Microbial infection) Accumulates 2 days post infection with turnip crinkle virus (TCV) (PubMed:24418554). {ECO:0000269\|PubMed:24418554}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_023877826.1	1e-74	NAC domain-containing protein 91-like
Refseq	XP_023880191.1	3e-70	disease resistance protein At4g27190-like
Swissprot	F4JN35	1e-46	NTL9_ARATH; Protein NTM1-like 9
Swissprot	Q9LKG8	6e-47	NAC91_ARATH; NAC domain-containing protein 91
TrEMBL	A0A3Q8TBI5	5e-49	A0A3Q8TBI5_DIOKA; Transcription factor NAC10
STRING	XP_006476249.1	1e-47	(Citrus sinensis)
STRING	XP_008360722.1	2e-47	(Malus domestica)
STRING	cassava4.1_032341m	5e-49	(Manihot esculenta)
STRING	XP_006439176.1	1e-47	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2065	25	86

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G24590.2	3e-49	TCV-interacting protein

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Zheng XY, et al. Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid. Proc. Natl. Acad. Sci. U.S.A., 2015. 112(30): p. 9166-73 [PMID:26139525] Ben Daniel BH, et al. Identification of novel transcriptional regulators of Zat12 using comprehensive yeast one-hybrid screens. Physiol Plant, 2016. 157(4): p. 422-41 [PMID:26923089] Li Y, et al. The interaction between Turnip crinkle virus p38 and Cucumber mosaic virus 2b and its critical domains. Virus Res., 2016. 222: p. 94-105 [PMID:27288723] Guo T, et al. Lamin-like Proteins Negatively Regulate Plant Immunity through NAC WITH TRANSMEMBRANE MOTIF1-LIKE9 and NONEXPRESSOR OF PR GENES1 in Arabidopsis thaliana. Mol Plant, 2017. 10(10): p. 1334-1348 [PMID:28943325]