PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID maker-scaffold00176-snap-gene-1.27-mRNA-1
Organism
Castanea mollissima
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Fagaceae; Castanea
Family E2F/DP
Protein Properties Length: 372aa    MW: 41616.6 Da    PI: 9.4909
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
maker-scaffold00176-snap-gene-1.27-mRNA-1genomeTHGPView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.62.2e-2361126171
                                    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneir 68 
                                                rk+ksL+ll+++fl+l+ + + + + l+++a++L    v  +rRRiYDi+NVLe+++++++++kn+++
  maker-scaffold00176-snap-gene-1.27-mRNA-1  61 RKQKSLGLLCSNFLSLYDRNDVRLIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLARRAKNQYT 123
                                                79*****************999************...**..*************************** PP

                                    E2F_TDP  69 wkg 71 
                                                wkg
  maker-scaffold00176-snap-gene-1.27-mRNA-1 124 WKG 126
                                                *98 PP
2E2F_TDP39.11.2e-121892263971
                                    E2F_TDP  39 vknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                                                 k k+RR+YDi+NVL++++liek     ++k+++rw g
  maker-scaffold00176-snap-gene-1.27-mRNA-1 189 LKAKVRRLYDIANVLSSMKLIEKthttdTRKPAFRWLG 226
                                                46799**********************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1014477.85E-52938No hitNo description
Gene3DG3DSA:1.10.10.102.1E-2557127IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.78E-1660124IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-2761126IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.2E-2062126IPR003316E2F/DP family, winged-helix DNA-binding domain
SMARTSM013723.4E-6162226IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.45E-8180227IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.0E-10184226IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.106.7E-13186227IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 372 aa     Download sequence    Send to blast
MASSLPSSTS VSPPDSPPLQ QQPHRSEQPP PPPPPPPPMA VPLPSSSTDL DTSSRHHTYS  60
RKQKSLGLLC SNFLSLYDRN DVRLIGLDDA ASRLGVERRR IYDIVNVLES VGVLARRAKN  120
QYTWKGFGAI PIALKELKEE GMRENTNGFD GNDYAKVSDD EDDDERLSNP STGSQNDKSN  180
PNSSVKCLLK AKVRRLYDIA NVLSSMKLIE KTHTTDTRKP AFRWLGCRGK AENEQAPVDS  240
RKRMFGSDIT NIGFKRSKVE SLFDTNLNQD LKVQKQGKLD SLVHDVDRGN SEHDSKQTLK  300
SYEFGPFAPA SVSKVGAPEN KSVKRVHDWE SLASTHRPQY QNQALKDLFS HYVEAWKSWY  360
SEVAGKKPIQ IS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-1760141388Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023908490.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ43e-99E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2N9FAK51e-179A0A2N9FAK5_FAGSY; Uncharacterized protein
STRINGXP_010111971.11e-149(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-102DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]