PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Caricaceae; Carica

Family

MYB

Protein Properties

Length: 266aa MW: 30453.2 Da PI: 6.9578

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
evm.model.supercontig_37.96	genome	ASGPB	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	43.3	8.4e-14	10	55	1	46
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 +g+W +eEde l++ v+++G+++W++I ++ + Rt+k+c++rw + evm.model.supercontig_37.96 10 KGPWKAEEDEVLINHVNKYGPRDWSSIRSKGLLQRTGKSCRLRWVN 55 79***********************8887799********87 PP
2	Myb_DNA-binding	44	5.2e-14	66	105	3	44
SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS Myb_DNA-binding 3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 ++++eE+ +d+ +q+G++ W++Ia +++ gRt++++k++w evm.model.supercontig_37.96 66 KFSAEEERVVIDLQAQFGNK-WARIATYLP-GRTDNDVKNFW 105 79****************.*****.********* PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.60	2.0E-21	5	58	IPR009057	Homeodomain-like
PROSITE profile	PS51294	21.291	5	61	IPR017930	Myb domain
SuperFamily	SSF46689	4.12E-28	8	105	IPR009057	Homeodomain-like
SMART	SM00717	6.7E-11	9	59	IPR001005	SANT/Myb domain
Pfam	PF00249	7.7E-12	10	55	IPR001005	SANT/Myb domain
CDD	cd00167	3.19E-11	12	57	No hit	No description
Gene3D	G3DSA:1.10.10.60	3.6E-18	59	111	IPR009057	Homeodomain-like
PROSITE profile	PS51294	18.096	62	113	IPR017930	Myb domain
SMART	SM00717	5.2E-12	63	111	IPR001005	SANT/Myb domain
CDD	cd00167	3.71E-10	66	105	No hit	No description
Pfam	PF00249	7.6E-12	66	105	IPR001005	SANT/Myb domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0048235	Biological Process	pollen sperm cell differentiation
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 266 aa Download sequence Send to blast
MEGKREEIRK GPWKAEEDEV LINHVNKYGP RDWSSIRSKG LLQRTGKSCR LRWVNKLRPN 60 LKNGCKFSAE EERVVIDLQA QFGNKWARIA TYLPGRTDND VKNFWSSRQK RLARILHNST 120 PSSSTSKSLK IKREIPTFRE PISMVTLPDL VNPNPNLDDA AALHLIDHHP TETNLHIPTP 180 TFSQENQRLL NRLDEDPYFF DVVLGPLDST EISLGQPFFE PARSCRHIMR DDENANSVTP 240 DSFFDDFPAD MFDQMESLPS PSHTS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h8a_C	1e-28	7	111	24	126	MYB TRANSFORMING PROTEIN
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269\|PubMed:15618418, ECO:0000269\|PubMed:15694308, ECO:0000269\|PubMed:19300502, ECO:0000269\|PubMed:21285328, ECO:0000269\|PubMed:24876252}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	evm.model.supercontig_37.96

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269\|PubMed:21441434, ECO:0000269\|PubMed:25057814}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021900525.1	0.0	transcription factor DUO1
Swissprot	A0A178VEK7	5e-98	DUO1_ARATH; Transcription factor DUO1
TrEMBL	A0A061DVG4	1e-108	A0A061DVG4_THECC; Myb-like HTH transcriptional regulator family protein, putative
STRING	evm.model.supercontig_37.96	0.0	(Carica papaya)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6551	28	42
Representative plant	OGRP5	17	1784

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G60460.1	3e-78	MYB family protein

Link Out ? help Back to Top
Phytozome	evm.model.supercontig_37.96

Publications ? help Back to Top
Zheng B,He H,Zheng Y,Wu W,McCormick S An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana. PLoS Genet., 2014. 10(7): p. e1004421 [PMID:25057814] Peters B, et al. A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter. Plant Physiol., 2017. 173(1): p. 280-293 [PMID:27624837] Zheng Z, et al. Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy. Plant Physiol., 2017. 174(3): p. 1764-1778 [PMID:28515145]