PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

estExt_Genewise1.C_20537

Common Name

COCSUDRAFT_21888

Organism

Coccomyxa subellipsoidea C-169

Taxonomic ID

574566

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Chlorophyta; Trebouxiophyceae; Trebouxiophyceae incertae sedis; Coccomyxaceae; Coccomyxa; Coccomyxa subellipsoidea

Family

C2H2

Protein Properties

Length: 272aa MW: 31755.8 Da PI: 9.0451

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
estExt_Genewise1.C_20537	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	11	0.0013	20	42	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 y C++C k F k +L rH ++ estExt_Genewise1.C_20537 20 YLCEYCLKYFGKKKTLLRHSAKC 42 66*****************8876 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51726	71.225	1	261	IPR002717	Histone acetyltransferase domain, MYST-type
SuperFamily	SSF55729	2.24E-105	1	262	IPR016181	Acyl-CoA N-acyltransferase
Gene3D	G3DSA:3.30.60.60	1.8E-18	1	43	No hit	No description
Gene3D	G3DSA:3.40.630.30	4.5E-73	45	190	IPR016181	Acyl-CoA N-acyltransferase
Pfam	PF01853	3.6E-83	47	226	IPR002717	Histone acetyltransferase domain, MYST-type
CDD	cd04301	0.00323	101	157	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0016573	Biological Process	histone acetylation
GO:0005634	Cellular Component	nucleus
GO:0004402	Molecular Function	histone acetyltransferase activity

Sequence ? help Back to Top
Protein Sequence Length: 272 aa Download sequence Send to blast
MDTWYYSPYP EPYNSLEKLY LCEYCLKYFG KKKTLLRHSA KCDLRHPPGD EIYRAATSPT 60 IAVFEVDGKR NKVYCQSLCL LSKLFLDHKT LYYDVDPFLF YILCERDQQG YHIVGYFSKE 120 KCSVEGYNLA CILTLPPYQR KGYGRFLIAF SYELSKKECK VGTPERPLSD LGQVSYRSYW 180 QRSVLELLYT HRGQLSIKDI SDRTAIRTDD IVRALEVLNL IKYWKGDHII SVTQRVIEEH 240 LRILDKKKVM GIDVSRLHWT PYVPANAVGK K*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2y0m_A	1e-113	1	261	18	276	PROBABLE HISTONE ACETYLTRANSFERASE MYST1
3qah_A	1e-112	1	261	44	302	Probable histone acetyltransferase MYST1
4dnc_A	1e-113	1	261	20	278	Histone acetyltransferase KAT8
4dnc_B	1e-113	1	261	20	278	Histone acetyltransferase KAT8
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Functional Description ? help Back to Top
Source	Description
UniProt	Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269\|PubMed:17877703, ECO:0000269\|PubMed:19040736, ECO:0000269\|PubMed:22170978, ECO:0000269\|PubMed:23273925}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269\|PubMed:22170978}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_005651328.1	0.0	histone acetyltransferase
Swissprot	Q9FLF7	1e-119	MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBL	I0Z815	0.0	I0Z815_COCSC; Histone acetyltransferase
STRING	XP_005651328.1	0.0	(Coccomyxa subellipsoidea)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Chlorophytae	OGCP213	2	2

Link Out ? help Back to Top
Entrez Gene	17044794

Publications ? help Back to Top
Latrasse D, et al. The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis. BMC Plant Biol., 2008. 8: p. 121 [PMID:19040736] Campi M,D'Andrea L,Emiliani J,Casati P Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA. Plant Physiol., 2012. 158(2): p. 981-95 [PMID:22170978] Blanc G, et al. The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation. Genome Biol., 2012. 13(5): p. R39 [PMID:22630137] Bari A,Orazova S,Ivashchenko A miR156- and miR171-binding sites in the protein-coding sequences of several plant genes. Biomed Res Int, 2013. 2013: p. 307145 [PMID:23936788] Xu Y, et al. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res., 2014. 42(17): p. 10960-74 [PMID:25183522] Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB 3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana. J Mol Model, 2016. 22(11): p. 256 [PMID:27709438] Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis. Front Plant Sci, 2017. 8: p. 1179 [PMID:28740501]