PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

MYB

Protein Properties

Length: 528aa MW: 58612.8 Da PI: 8.0822

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016501753.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	50.1	6.4e-16	59	105	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g WT+eEd+ l++av+ + g++Wk+Ia+ ++ R++ qc +rwqk+l XP_016501753.1 59 KGGWTPEEDDSLKRAVAVFRGKCWKKIAEFFP-DRSEVQCLHRWQKVL 105 688***************************.**********986 PP
2	Myb_DNA-binding	57.3	3.5e-18	111	157	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g+WT eEd++++++v+++G+ W+ Ia+ ++ gR +kqc++rw+++l XP_016501753.1 111 KGPWTREEDDKIIELVAKYGPMKWSVIAKSLP-GRIGKQCRERWHNHL 157 79****************99******.***********97 PP
3	Myb_DNA-binding	57.2	3.8e-18	163	206	1	46
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 +++WT eE+ l+da++ +G++ W+ Ia+ ++ gRt++ +k++w++ XP_016501753.1 163 KDAWTLEEERALIDAHRIHGNK-WAEIAKVLP-GRTDNAIKNHWNS 206 679*****************.*****.*********96 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	14.968	54	105	IPR017930	Myb domain
SuperFamily	SSF46689	2.3E-14	56	112	IPR009057	Homeodomain-like
SMART	SM00717	4.7E-14	58	107	IPR001005	SANT/Myb domain
Pfam	PF00249	9.4E-15	59	105	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	3.4E-18	61	114	IPR009057	Homeodomain-like
CDD	cd00167	2.54E-12	62	105	No hit	No description
PROSITE profile	PS51294	31.737	106	161	IPR017930	Myb domain
SuperFamily	SSF46689	2.21E-31	108	204	IPR009057	Homeodomain-like
SMART	SM00717	6.8E-17	110	159	IPR001005	SANT/Myb domain
CDD	cd00167	6.96E-15	113	157	No hit	No description
Pfam	PF13921	1.2E-17	114	174	No hit	No description
Gene3D	G3DSA:1.10.10.60	1.3E-27	115	164	IPR009057	Homeodomain-like
PROSITE profile	PS51294	23.595	162	212	IPR017930	Myb domain
SMART	SM00717	9.7E-18	162	210	IPR001005	SANT/Myb domain
CDD	cd00167	1.85E-13	165	208	No hit	No description
Gene3D	G3DSA:1.10.10.60	1.3E-23	165	212	IPR009057	Homeodomain-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 528 aa Download sequence Send to blast
MAELKVEDCC TENKQSAAAS NSSVSENSAS VTLRSPTVSS PTPTSPTHRR TSGPIRRAKG 60 GWTPEEDDSL KRAVAVFRGK CWKKIAEFFP DRSEVQCLHR WQKVLNPDLV KGPWTREEDD 120 KIIELVAKYG PMKWSVIAKS LPGRIGKQCR ERWHNHLNPN IKKDAWTLEE ERALIDAHRI 180 HGNKWAEIAK VLPGRTDNAI KNHWNSSLRK KLDFYLATGN LPPATRDGLQ NGCKDTTETA 240 KAEELLAASS GTADMCKIEN GWQVAEISAS NGGPQTDSTD SEVVRLEAQS PEIDAIRHIQ 300 PSTESENMYE GRRINSVVDR LKVVEAPFRC EIPACGTLYY EPPTSESCIP LDSDLLNIRW 360 AQCESDASPS PSPNGFFTPP STKSSSLYAQ TPESVLKIAA RSFPNTPSIL RKRKTQAKLS 420 TPTNKMGKSD GDFCKDKPID ACEEILPRNS SNGIGLYNSQ AFNASPPYRL RSRRTSIFKS 480 VEKQLEFTLD NEKHDISNGI SESTVNDISH AAKDCSQSAK KDTDKKVE

Sequence ? help Back to Top

Protein Sequence Length: 528 aa Download sequence Send to blast

MAELKVEDCC TENKQSAAAS NSSVSENSAS VTLRSPTVSS PTPTSPTHRR TSGPIRRAKG  60
GWTPEEDDSL KRAVAVFRGK CWKKIAEFFP DRSEVQCLHR WQKVLNPDLV KGPWTREEDD  120
KIIELVAKYG PMKWSVIAKS LPGRIGKQCR ERWHNHLNPN IKKDAWTLEE ERALIDAHRI  180
HGNKWAEIAK VLPGRTDNAI KNHWNSSLRK KLDFYLATGN LPPATRDGLQ NGCKDTTETA  240
KAEELLAASS GTADMCKIEN GWQVAEISAS NGGPQTDSTD SEVVRLEAQS PEIDAIRHIQ  300
PSTESENMYE GRRINSVVDR LKVVEAPFRC EIPACGTLYY EPPTSESCIP LDSDLLNIRW  360
AQCESDASPS PSPNGFFTPP STKSSSLYAQ TPESVLKIAA RSFPNTPSIL RKRKTQAKLS  420
TPTNKMGKSD GDFCKDKPID ACEEILPRNS SNGIGLYNSQ AFNASPPYRL RSRRTSIFKS  480
VEKQLEFTLD NEKHDISNGI SESTVNDISH AAKDCSQSAK KDTDKKVE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h88_C	1e-70	58	212	5	159	MYB PROTO-ONCOGENE PROTEIN
1h89_C	1e-70	58	212	5	159	MYB PROTO-ONCOGENE PROTEIN
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Transcription repressor that regulates organ growth. Binds to the promoters of G2/M-specific genes and to E2F target genes to prevent their expression in post-mitotic cells and to restrict the time window of their expression in proliferating cells (PubMed:26069325). {ECO:0000250\|UniProtKB:Q94FL9, ECO:0000269\|PubMed:26069325}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00482	DAP	Transfer from AT5G02320	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Slightly induced by ethylene and salicylic acid (SA). {ECO:0000269\|PubMed:16463103}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	HG975448	0.0	HG975448.1 Solanum pennellii chromosome ch09, complete genome.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016501753.1	0.0	PREDICTED: myb-related protein B-like
Swissprot	Q6R032	1e-149	MB3R5_ARATH; Transcription factor MYB3R-5
TrEMBL	A0A1S4CKM8	0.0	A0A1S4CKM8_TOBAC; myb-related protein B-like
STRING	XP_009596030.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA5461	24	37

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G02320.2	1e-134	myb domain protein 3r-5

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Chen P, et al. Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]