PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

C2H2

Protein Properties

Length: 501aa MW: 53718.2 Da PI: 8.3087

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016482648.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	17.2	1.4e-05	58	80	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H XP_016482648.1 58 FVCEICNKGFQRDQNLQLHRRGH 80 89*******************88 PP
2	zf-C2H2	16.7	2.1e-05	134	156	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC+ C+k + +s+ k H++t+ XP_016482648.1 134 FKCERCTKKYAVQSDWKAHMKTC 156 89*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	2.13E-7	57	80	No hit	No description
Gene3D	G3DSA:3.30.160.60	1.6E-5	57	80	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Pfam	PF12171	8.0E-5	58	80	IPR022755	Zinc finger, double-stranded RNA binding
SMART	SM00355	0.017	58	80	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.949	58	80	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	60	80	IPR007087	Zinc finger, C2H2
SMART	SM00355	250	99	129	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	2.6E-5	122	155	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	2.13E-7	129	155	No hit	No description
SMART	SM00355	63	134	154	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 501 aa Download sequence Send to blast
MADMENSSSM TVAGSSLEET ISQQNFPVKK KRNLPGNPDP EAEVIALSPK ALMATNRFVC 60 EICNKGFQRD QNLQLHRRGH NLPWKLRQRT SKEVKKRVYV CPEATCIHHD PSRALGDLTG 120 IKKHFCRKHG EKKFKCERCT KKYAVQSDWK AHMKTCGTRE YRCDCGTLFS RRDSFVTHRA 180 FCDALAQESA RAQPMGITNT EENLKADEAV TSSSSPPPQP LTPSTGVLSP VLSIQSSELP 240 ADNQNQAGVQ LQAAQGTTTP VSTTTVTATT ISTTASTTGP SSSKVFASVF PSSSTSVGHP 300 HSSYSNILCA IGPEQMTAIE PMSLSLSSSF YLSANNGSTL FQDHTGHVQH YGSTTQPALS 360 ATALLQKAAQ MGATSSNNSF LRGLGLAMSS TSTSDNISRV KLENNVELPG LGIPLPSNGP 420 SGQWTDLMMG PSHESMMFGN KPPTLDFLGL GNDANVTSSN GFSALLSSMD GGFGVATSSY 480 GGVATRGQPW DDHSDRKPSM L

Sequence ? help Back to Top

Protein Sequence Length: 501 aa Download sequence Send to blast

MADMENSSSM TVAGSSLEET ISQQNFPVKK KRNLPGNPDP EAEVIALSPK ALMATNRFVC  60
EICNKGFQRD QNLQLHRRGH NLPWKLRQRT SKEVKKRVYV CPEATCIHHD PSRALGDLTG  120
IKKHFCRKHG EKKFKCERCT KKYAVQSDWK AHMKTCGTRE YRCDCGTLFS RRDSFVTHRA  180
FCDALAQESA RAQPMGITNT EENLKADEAV TSSSSPPPQP LTPSTGVLSP VLSIQSSELP  240
ADNQNQAGVQ LQAAQGTTTP VSTTTVTATT ISTTASTTGP SSSKVFASVF PSSSTSVGHP  300
HSSYSNILCA IGPEQMTAIE PMSLSLSSSF YLSANNGSTL FQDHTGHVQH YGSTTQPALS  360
ATALLQKAAQ MGATSSNNSF LRGLGLAMSS TSTSDNISRV KLENNVELPG LGIPLPSNGP  420
SGQWTDLMMG PSHESMMFGN KPPTLDFLGL GNDANVTSSN GFSALLSSMD GGFGVATSSY  480
GGVATRGQPW DDHSDRKPSM L

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	5e-34	130	199	3	72	Zinc finger protein JACKDAW
5b3h_F	5e-34	130	199	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016482648.1	0.0	PREDICTED: protein indeterminate-domain 2-like isoform X1
Swissprot	Q9SCQ6	1e-135	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A1S4B1I1	0.0	A0A1S4B1I1_TOBAC; protein indeterminate-domain 2-like isoform X1
STRING	XP_009805007.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA103	24	350

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G50700.1	1e-113	indeterminate(ID)-domain 2

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]