PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

C2H2

Protein Properties

Length: 443aa MW: 49482.3 Da PI: 8.552

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016474598.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.6	2.2e-05	73	95	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 + C+ C+k F r nL+ H r H XP_016474598.1 73 FICEVCNKGFQREQNLQLHRRGH 95 89*******************88 PP
2	zf-C2H2	10.8	0.0016	151	173	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC C+k + +s+ k H +t+ XP_016474598.1 151 WKCDRCSKKYAVQSDWKAHSKTC 173 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	1.04E-7	72	95	No hit	No description
Gene3D	G3DSA:3.30.160.60	4.7E-6	72	95	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.0052	73	95	IPR015880	Zinc finger, C2H2-like
Pfam	PF12171	2.1E-5	73	95	IPR022755	Zinc finger, double-stranded RNA binding
PROSITE profile	PS50157	10.99	73	95	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	75	95	IPR007087	Zinc finger, C2H2
SMART	SM00355	88	116	146	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	6.5E-5	139	172	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.04E-7	146	171	No hit	No description
SMART	SM00355	250	151	171	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 443 aa Download sequence Send to blast
MSNISSGNSS TAGAEEEYEE QDQQQTSNVL LPSSVHQEQD LPNKKRRKLP GNPDPSAEVI 60 ALSPKTLMAT NRFICEVCNK GFQREQNLQL HRRGHNLPWK LKQKTSSDEI RKRRVYICPE 120 PTCIHHNPAR ALGDLTGIKK HYSRKHGEKK WKCDRCSKKY AVQSDWKAHS KTCGTKEYKC 180 DCGTIFSRRD SFITHRAFCD ALTEENNKVN QSLASTTGPS HTPVSEVMPT SMLNLSEIRN 240 PNMKIPLKPS PRELNIQTPT GPLLNMAGSM FTSPRNLSSS SFSGFQLSTN SSNMSSSATA 300 LLQQAAQMGA TVSSSMNSPI MVQKGYPSLF QSDHNQTQIG SSVHGFFGSM LQNGTQETLI 360 SELLNSNSTA GDNQKTSRMQ NEGWYNGLFN ETKINGESGN DSLTLDFLGI GGMRQRNSHE 420 MHQQQQQEMS FEQQKEMSSM WDD

Sequence ? help Back to Top

Protein Sequence Length: 443 aa Download sequence Send to blast

MSNISSGNSS TAGAEEEYEE QDQQQTSNVL LPSSVHQEQD LPNKKRRKLP GNPDPSAEVI  60
ALSPKTLMAT NRFICEVCNK GFQREQNLQL HRRGHNLPWK LKQKTSSDEI RKRRVYICPE  120
PTCIHHNPAR ALGDLTGIKK HYSRKHGEKK WKCDRCSKKY AVQSDWKAHS KTCGTKEYKC  180
DCGTIFSRRD SFITHRAFCD ALTEENNKVN QSLASTTGPS HTPVSEVMPT SMLNLSEIRN  240
PNMKIPLKPS PRELNIQTPT GPLLNMAGSM FTSPRNLSSS SFSGFQLSTN SSNMSSSATA  300
LLQQAAQMGA TVSSSMNSPI MVQKGYPSLF QSDHNQTQIG SSVHGFFGSM LQNGTQETLI  360
SELLNSNSTA GDNQKTSRMQ NEGWYNGLFN ETKINGESGN DSLTLDFLGI GGMRQRNSHE  420
MHQQQQQEMS FEQQKEMSSM WDD

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	9e-35	147	210	3	66	Zinc finger protein JACKDAW
5b3h_F	9e-35	147	210	3	66	Zinc finger protein JACKDAW
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	43	47	KKRRK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009784070.1	0.0	PREDICTED: zinc finger protein MAGPIE-like
Refseq	XP_016474598.1	0.0	PREDICTED: protein indeterminate-domain 2-like
Swissprot	Q9SCQ6	1e-109	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A1S4ADS3	0.0	A0A1S4ADS3_TOBAC; protein indeterminate-domain 2-like
TrEMBL	A0A1U7XC88	0.0	A0A1U7XC88_NICSY; zinc finger protein MAGPIE-like
STRING	XP_009784070.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA103	24	350

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G14580.2	1e-105	C2H2-like zinc finger protein

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]