PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

C2H2

Protein Properties

Length: 514aa MW: 57305.7 Da PI: 6.3774

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016457123.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	21	8.6e-07	263	284	2	23
EETTTTEEESSHHHHHHHHHHT CS zf-C2H2 2 kCpdCgksFsrksnLkrHirtH 23 C++Cgk F+r nL+ H+r H XP_016457123.1 263 FCTICGKGFKRDANLRMHMRGH 284 6*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	2.29E-5	260	287	No hit	No description
SMART	SM00355	0.0026	262	284	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	12.03	262	289	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	7.3E-6	263	313	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	264	284	IPR007087	Zinc finger, C2H2
SMART	SM00355	100	311	344	IPR015880	Zinc finger, C2H2-like
SMART	SM00355	25	349	371	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 514 aa Download sequence Send to blast
MDPDDSLSED PWTKPSSSGN ELLKIVPSDN HSFTNFNLHA QKWEGSSYLD QQTRIEQQFS 60 GFTQPKHTYQ MDQHGNQMNE NHDSTSTKDW DPSNLLNNLS FLEQKIHQLQ ELVHLIVGRR 120 GQTGLQGNDL IVQQQQLITA DLTSIIVQLV STAGSLLPTM KHSLSSVSHA ASQLVQFGGV 180 TVPSATCTNG GGLPCNDGGV TKVEDQSNHV DQLRDCGIEQ SHAVDGHESK DEDEAEEEEN 240 LPPGSYEILQ LEKEEILAPH THFCTICGKG FKRDANLRMH MRGHGDEYKT PAALAKPHKE 300 PSSEPTLIKR YSCPNVGCKR NKEHKKFQPL KTILCVKNHY KRTHCEKAYT CSRCNIKKFS 360 VIADLKTHEK HCGKDKWLCS CGTTFSRKDK LFGHIALFQG HTPAVPLDET KGSAGTSDRG 420 QTSEVTMKAR QEDFKVNASH GNEFQDPRDI KSAADDPGSY FSPLNFDTSN LNGFQEFPRP 480 PFDESDSSFS FLLSGSCEYP PHKAAKYMSS TELE

Sequence ? help Back to Top

Protein Sequence Length: 514 aa Download sequence Send to blast

MDPDDSLSED PWTKPSSSGN ELLKIVPSDN HSFTNFNLHA QKWEGSSYLD QQTRIEQQFS  60
GFTQPKHTYQ MDQHGNQMNE NHDSTSTKDW DPSNLLNNLS FLEQKIHQLQ ELVHLIVGRR  120
GQTGLQGNDL IVQQQQLITA DLTSIIVQLV STAGSLLPTM KHSLSSVSHA ASQLVQFGGV  180
TVPSATCTNG GGLPCNDGGV TKVEDQSNHV DQLRDCGIEQ SHAVDGHESK DEDEAEEEEN  240
LPPGSYEILQ LEKEEILAPH THFCTICGKG FKRDANLRMH MRGHGDEYKT PAALAKPHKE  300
PSSEPTLIKR YSCPNVGCKR NKEHKKFQPL KTILCVKNHY KRTHCEKAYT CSRCNIKKFS  360
VIADLKTHEK HCGKDKWLCS CGTTFSRKDK LFGHIALFQG HTPAVPLDET KGSAGTSDRG  420
QTSEVTMKAR QEDFKVNASH GNEFQDPRDI KSAADDPGSY FSPLNFDTSN LNGFQEFPRP  480
PFDESDSSFS FLLSGSCEYP PHKAAKYMSS TELE

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269\|PubMed:17535918, ECO:0000269\|PubMed:18826429, ECO:0000269\|PubMed:19321711, ECO:0000269\|PubMed:23935008}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269\|PubMed:17535918}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AB811781	0.0	AB811781.1 Nicotiana tabacum NtSTOP1 mRNA for STOP1-like protein, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009801047.1	0.0	PREDICTED: protein SENSITIVE TO PROTON RHIZOTOXICITY 1
Swissprot	Q9C8N5	0.0	STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBL	A0A1S3YYC8	0.0	A0A1S3YYC8_TOBAC; protein SENSITIVE TO PROTON RHIZOTOXICITY 1-like
TrEMBL	A0A1U7YAA5	0.0	A0A1U7YAA5_NICSY; protein SENSITIVE TO PROTON RHIZOTOXICITY 1
STRING	XP_009801047.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA4754	24	41

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G34370.2	1e-169	C2H2 family protein

Publications ? help Back to Top
Ohyama Y, et al. Characterization of AtSTOP1 orthologous genes in tobacco and other plant species. Plant Physiol., 2013. 162(4): p. 1937-46 [PMID:23749850] Kobayashi Y, et al. Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions. Plant Physiol., 2013. 163(1): p. 180-92 [PMID:23839867] Yokosho K,Yamaji N,Ma JF Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench). Plant Cell Physiol., 2014. 55(12): p. 2077-91 [PMID:25273892] Geng X, et al. LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis. Plant J., 2017. 90(3): p. 491-504 [PMID:28181322] Balzergue C, et al. Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation. Nat Commun, 2017. 8: p. 15300 [PMID:28504266] Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation. Front Plant Sci, 2017. 8: p. 822 [PMID:28567051] Jiang F, et al. Identification and characterization of suppressor mutants of stop1. BMC Plant Biol., 2017. 17(1): p. 128 [PMID:28738784] Daspute AA, et al. Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms. Front Plant Sci, 2017. 8: p. 1358 [PMID:28848571] Sharma A,Wai CM,Ming R,Yu Q Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis. Genome Biol Evol, 2017. 9(9): p. 2170-2190 [PMID:28922793] Zhang Y, et al. The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis. Front Plant Sci, 2018. 9: p. 118 [PMID:29491872]