PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016456690.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family C2H2
Protein Properties Length: 378aa    MW: 42052.5 Da    PI: 6.5552
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016456690.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H2201.9e-06156177223
                     EETTTTEEESSHHHHHHHHHHT CS
         zf-C2H2   2 kCpdCgksFsrksnLkrHirtH 23 
                      C  Cgk F+r  nL+ H+r H
  XP_016456690.1 156 FCDFCGKGFKRDANLRMHMRAH 177
                     6*******************99 PP
2zf-C2H211.70.00082241264123
                     EEETTTT.EEESSHHHHHHHHHHT CS
         zf-C2H2   1 ykCpdCg.ksFsrksnLkrHirtH 23 
                     y+C+ C+ ksFs   +Lk+H++ +
  XP_016456690.1 241 YSCTRCNkKSFSVLADLKSHLKHC 264
                     99*******************977 PP
3zf-C2H211.80.00075272288521
                     TTTEEESSHHHHHHHHH CS
         zf-C2H2   5 dCgksFsrksnLkrHir 21 
                      Cg+sFsrk+ L  H+ 
  XP_016456690.1 272 SCGTSFSRKDKLFGHMA 288
                     5**************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576674.85E-6152178No hitNo description
SMARTSM003550.0024155177IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.605.7E-6155177IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015712.092155182IPR007087Zinc finger, C2H2
PROSITE patternPS000280157177IPR007087Zinc finger, C2H2
SMARTSM00355150203236IPR015880Zinc finger, C2H2-like
SMARTSM0035514241263IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.600.001263288IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM00355210269293IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 378 aa     Download sequence    Send to blast
MSFFGDLRHT PSQTKPPLTT MSAASTIGDD PRAPLLNLSA VQVRMDSLQK FLSDSINSNT  60
LLGQQQMNMV SDEITSAIHQ IIVNGAALLS SAQSPNHQPP PQSPELKMNP KSNHKRTFSE  120
FDGRGSEVEL LEEEDGDDWE IIELDAVELL AEHIHFCDFC GKGFKRDANL RMHMRAHGNQ  180
YKTPEALAKP DKCIESSSKN RRFSCPFVGC CRNKSHSKFR PLKSAICVKN HFKRSHCPKM  240
YSCTRCNKKS FSVLADLKSH LKHCGETKWK CSCGTSFSRK DKLFGHMALF EGHMPAIEPE  300
EEAKPPAAAA VEDDVEMDVS RGSDNGFLDI RTGSDNGFLD RLMLDGLESI DSYCFQDLLG  360
SSSPSGLNTV PDTNEWFS
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269|PubMed:17535918, ECO:0000269|PubMed:18826429, ECO:0000269|PubMed:19321711, ECO:0000269|PubMed:23935008}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269|PubMed:17535918}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016456690.10.0PREDICTED: protein SENSITIVE TO PROTON RHIZOTOXICITY 1-like
SwissprotQ9C8N52e-82STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBLA0A1S3YX710.0A0A1S3YX71_TOBAC; protein SENSITIVE TO PROTON RHIZOTOXICITY 1-like
STRINGXP_009626824.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA100002126
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G34370.31e-70C2H2 family protein
Publications ? help Back to Top
  1. Kobayashi Y, et al.
    Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions.
    Plant Physiol., 2013. 163(1): p. 180-92
    [PMID:23839867]
  2. Yokosho K,Yamaji N,Ma JF
    Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench).
    Plant Cell Physiol., 2014. 55(12): p. 2077-91
    [PMID:25273892]
  3. Geng X, et al.
    LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis.
    Plant J., 2017. 90(3): p. 491-504
    [PMID:28181322]
  4. Balzergue C, et al.
    Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation.
    Nat Commun, 2017. 8: p. 15300
    [PMID:28504266]
  5. Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A
    Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation.
    Front Plant Sci, 2017. 8: p. 822
    [PMID:28567051]
  6. Jiang F, et al.
    Identification and characterization of suppressor mutants of stop1.
    BMC Plant Biol., 2017. 17(1): p. 128
    [PMID:28738784]
  7. Daspute AA, et al.
    Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms.
    Front Plant Sci, 2017. 8: p. 1358
    [PMID:28848571]
  8. Sharma A,Wai CM,Ming R,Yu Q
    Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis.
    Genome Biol Evol, 2017. 9(9): p. 2170-2190
    [PMID:28922793]
  9. Zhang Y, et al.
    The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis.
    Front Plant Sci, 2018. 9: p. 118
    [PMID:29491872]