PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

C2H2

Protein Properties

Length: 468aa MW: 51971.3 Da PI: 9.1921

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016453136.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.7	4.2e-05	53	73	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C++Cgk F r nL+ H r H XP_016453136.1 53 CEICGKGFQRDQNLQLHRRGH 73 *******************88 PP
2	zf-C2H2	13.5	0.00021	127	149	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC++C+k++ +s+ k H +t+ XP_016453136.1 127 WKCEKCSKRYAVQSDWKAHSKTC 149 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	3.23E-6	50	73	No hit	No description
Gene3D	G3DSA:3.30.160.60	4.0E-5	50	73	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.076	51	73	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	11.489	51	73	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	53	73	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	5.3E-5	115	148	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	3.23E-6	122	147	No hit	No description
SMART	SM00355	130	127	147	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 468 aa Download sequence Send to blast
MTEEVILSGF NSIEGSNPLP LKKKRNLPGN PDPEAEVIAL SPKTLMATNR FLCEICGKGF 60 QRDQNLQLHR RGHNLPWKLK QRTSKEVRKR VYVCPEKSCV HHHASRALGD LTGIKKHYCR 120 KHGEKKWKCE KCSKRYAVQS DWKAHSKTCG TREYRCDCGT IFSRRDSFVT HRAFCDALAE 180 ETARVTAASN MHNPLAGNNI DYHFIGSPLG PNMAQHFSSL FKPISTNNEN SDPIMRRDQL 240 SLWNMGQVSQ QQETIGNNNL QEIHQISPLI QTSAAAVYDT NTLLAPRSNP PPVNYNHVNW 300 QQLTNTSSAN ISVPSLFSTQ HQSHQQITPS STASMSATAL LQKAAQIGAT TTTTDPSFLG 360 NNFGMNNCNV KNNNVQVQEV NNNKFCGFYV TTTNNSISTS LGSEVDQGSV NDFSTLNQLQ 420 MYNPPSKRRH IITREDSVTG GGVGGQTRDF LGVGVQSICH PSSINGWI

Sequence ? help Back to Top

Protein Sequence Length: 468 aa Download sequence Send to blast

MTEEVILSGF NSIEGSNPLP LKKKRNLPGN PDPEAEVIAL SPKTLMATNR FLCEICGKGF  60
QRDQNLQLHR RGHNLPWKLK QRTSKEVRKR VYVCPEKSCV HHHASRALGD LTGIKKHYCR  120
KHGEKKWKCE KCSKRYAVQS DWKAHSKTCG TREYRCDCGT IFSRRDSFVT HRAFCDALAE  180
ETARVTAASN MHNPLAGNNI DYHFIGSPLG PNMAQHFSSL FKPISTNNEN SDPIMRRDQL  240
SLWNMGQVSQ QQETIGNNNL QEIHQISPLI QTSAAAVYDT NTLLAPRSNP PPVNYNHVNW  300
QQLTNTSSAN ISVPSLFSTQ HQSHQQITPS STASMSATAL LQKAAQIGAT TTTTDPSFLG  360
NNFGMNNCNV KNNNVQVQEV NNNKFCGFYV TTTNNSISTS LGSEVDQGSV NDFSTLNQLQ  420
MYNPPSKRRH IITREDSVTG GGVGGQTRDF LGVGVQSICH PSSINGWI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	3e-36	123	190	3	70	Zinc finger protein JACKDAW
5b3h_F	3e-36	123	190	3	70	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440). Interacts with the SCR and MGP promoters (PubMed:21935722). Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). Positively involved in gibberellic acid (GA) signaling (PubMed:24821766). {ECO:0000269\|PubMed:17785527, ECO:0000269\|PubMed:21935722, ECO:0000269\|PubMed:24821766, ECO:0000269\|PubMed:25829440}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by the transcription factor JKD, and down-regulated by SHR, SCR and itself. {ECO:0000269\|PubMed:21935722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	HG975446	1e-132	HG975446.1 Solanum pennellii chromosome ch07, complete genome.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009765644.1	0.0	PREDICTED: zinc finger protein MAGPIE-like
Refseq	XP_009765645.1	0.0	PREDICTED: zinc finger protein MAGPIE-like
Refseq	XP_016453136.1	0.0	PREDICTED: zinc finger protein MAGPIE-like
Refseq	XP_016453137.1	0.0	PREDICTED: zinc finger protein MAGPIE-like
Swissprot	Q9ZWA6	1e-154	IDD3_ARATH; Zinc finger protein MAGPIE
TrEMBL	A0A1S3YLJ7	0.0	A0A1S3YLJ7_TOBAC; zinc finger protein MAGPIE-like
TrEMBL	A0A1U7VTC3	0.0	A0A1U7VTC3_NICSY; zinc finger protein MAGPIE-like
STRING	XP_009765644.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA103	24	350

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	1e-149	C2H2 family protein

Publications ? help Back to Top
Muñoz-Strale D,León G Identification of two highly specific pollen promoters using transcriptomic data. Plant Physiol. Biochem., 2014. 83: p. 292-9 [PMID:25208507] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755]