PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

MIKC_MADS

Protein Properties

Length: 211aa MW: 24587.2 Da PI: 9.4357

Description

MIKC_MADS family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016435497.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	SRF-TF	94.5	4.9e-30	9	59	1	51
S---SHHHHHHHHHHHHHHHHHHHHHHHHHHT-EEEEEEE-TTSEEEEEE- CS SRF-TF 1 krienksnrqvtfskRrngilKKAeELSvLCdaevaviifsstgklyeyss 51 krien + rqvtfskRr gilKKA+ELSvLCdaeva+i+fs++g+lye+ss XP_016435497.1 9 KRIENATSRQVTFSKRRSGILKKAFELSVLCDAEVALIVFSPKGRLYEFSS 59 79***********************************************96 PP
2	K-box	71.1	3.5e-24	83	173	9	99
K-box 9 leeakaeslqqelakLkkeienLqreqRhllGedLesLslkeLqqLeqqLekslkkiRskKnellleqieelqkkekelqeenkaLrkkle 99 +e +++e+l++e+a + +++e L+ ++R+llG++L+s s+ eLqq+e+qLe+sl+ iR++Kn ll+eqi +l++ ek l ++n +Lrk++e XP_016435497.1 83 AEIQTTEHLKEEVATMTRKLELLEDSKRKLLGQGLDSSSFDELQQVEEQLERSLSCIRARKNLLLREQIAHLKEEEKILMKQNADLRKRIE 173 566889**********************************************************************************986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00432	3.1E-40	1	60	IPR002100	Transcription factor, MADS-box
PROSITE profile	PS50066	31.595	1	61	IPR002100	Transcription factor, MADS-box
CDD	cd00265	9.05E-42	3	72	No hit	No description
PRINTS	PR00404	4.8E-30	3	23	IPR002100	Transcription factor, MADS-box
SuperFamily	SSF55455	3.79E-32	3	72	IPR002100	Transcription factor, MADS-box
PROSITE pattern	PS00350	0	3	57	IPR002100	Transcription factor, MADS-box
Pfam	PF00319	3.6E-26	10	57	IPR002100	Transcription factor, MADS-box
PRINTS	PR00404	4.8E-30	23	38	IPR002100	Transcription factor, MADS-box
PRINTS	PR00404	4.8E-30	38	59	IPR002100	Transcription factor, MADS-box
Pfam	PF01486	1.8E-22	85	172	IPR002487	Transcription factor, K-box
PROSITE profile	PS51297	14.035	88	187	IPR002487	Transcription factor, K-box

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 211 aa Download sequence Send to blast
MVRGKTEMKR IENATSRQVT FSKRRSGILK KAFELSVLCD AEVALIVFSP KGRLYEFSSS 60 STNKTIERYQ KNDRYLGPNR KIAEIQTTEH LKEEVATMTR KLELLEDSKR KLLGQGLDSS 120 SFDELQQVEE QLERSLSCIR ARKNLLLREQ IAHLKEEEKI LMKQNADLRK RIEVVPLPLK 180 IDSREEEDPQ RQTMELETEL FIGLPQRQSS H

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1tqe_P	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
1tqe_Q	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
1tqe_R	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
1tqe_S	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
5f28_A	2e-17	1	69	1	69	MEF2C
5f28_B	2e-17	1	69	1	69	MEF2C
5f28_C	2e-17	1	69	1	69	MEF2C
5f28_D	2e-17	1	69	1	69	MEF2C
6byy_A	2e-17	1	69	1	69	MEF2 CHIMERA
6byy_B	2e-17	1	69	1	69	MEF2 CHIMERA
6byy_C	2e-17	1	69	1	69	MEF2 CHIMERA
6byy_D	2e-17	1	69	1	69	MEF2 CHIMERA
6bz1_A	2e-17	1	69	1	69	MEF2 CHIMERA
6bz1_B	2e-17	1	69	1	69	MEF2 CHIMERA
6c9l_A	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
6c9l_B	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
6c9l_C	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
6c9l_D	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
6c9l_E	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
6c9l_F	2e-17	1	69	1	69	Myocyte-specific enhancer factor 2B
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor that promotes flowering, especially in response to vernalization by short periods of cold, in an FLC-inpedendent manner. {ECO:0000269\|PubMed:16778081}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Maintained at very low levels by the polycomb-group (PcG) proteins MSI1, CLF, and EMF2 via histone methylation (H3K27me3). Derepressed upon cold treatment (vernalization). {ECO:0000269\|PubMed:16778081}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC244195	4e-63	AC244195.1 Solanum lycopersicum strain Heinz 1706 chromosome 8 clone hba-6a9 map 8, complete sequence.
GenBank	HG975447	4e-63	HG975447.1 Solanum pennellii chromosome ch08, complete genome.
GenBank	HG975520	4e-63	HG975520.1 Solanum lycopersicum chromosome ch08, complete genome.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009772098.1	1e-151	PREDICTED: agamous-like MADS-box protein AGL19
Refseq	XP_016435497.1	1e-151	PREDICTED: agamous-like MADS-box protein AGL19
Swissprot	O82743	1e-69	AGL19_ARATH; Agamous-like MADS-box protein AGL19
TrEMBL	A0A1S3X6K8	1e-150	A0A1S3X6K8_TOBAC; agamous-like MADS-box protein AGL19
TrEMBL	A0A1U7W0H1	1e-150	A0A1U7W0H1_NICSY; agamous-like MADS-box protein AGL19
STRING	XP_009772098.1	1e-151	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA40	24	625

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G22950.1	4e-72	AGAMOUS-like 19

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Suter L,Rüegg M,Zemp N,Hennig L,Widmer A Gene regulatory variation mediates flowering responses to vernalization along an altitudinal gradient in Arabidopsis. Plant Physiol., 2014. 166(4): p. 1928-42 [PMID:25339407]