PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rhamnaceae; Paliureae; Ziziphus

Family

C2H2

Protein Properties

Length: 472aa MW: 51190.5 Da PI: 9.1232

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_015881278.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.7	4.2e-05	57	77	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C++Cgk F r nL+ H r H XP_015881278.1 57 CEICGKGFQRDQNLQLHRRGH 77 *******************88 PP
2	zf-C2H2	13.5	0.00022	131	153	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC++C+k++ +s+ k H +t+ XP_015881278.1 131 WKCEKCSKRYAVQSDWKAHSKTC 153 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	1.27E-6	54	77	No hit	No description
Gene3D	G3DSA:3.30.160.60	4.1E-5	54	77	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	11.489	55	77	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.076	55	77	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	57	77	IPR007087	Zinc finger, C2H2
SMART	SM00355	260	96	126	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	1.5E-4	119	152	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.27E-6	126	151	No hit	No description
SMART	SM00355	130	131	151	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010150	Biological Process	leaf senescence
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0048510	Biological Process	regulation of timing of transition from vegetative to reproductive phase
GO:0048573	Biological Process	photoperiodism, flowering
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 472 aa Download sequence Send to blast
MAEEAISSGF VQNPISGGSD NPPAVKKKRN LPGTPDPEAE VIALSPKTLM ATNRFLCEIC 60 GKGFQRDQNL QLHRRGHNLP WKLKQRTSKE PRKRVYVCPE KSCVHNHPSR ALGDLTGIKK 120 HFCRKHGEKK WKCEKCSKRY AVQSDWKAHS KTCGTREYKC DCGTLFSRRD SFITHRAFCD 180 ALAEETARLN AASNISNSMA AGNINYHFIG TSLAPTMATQ PFPSVFKPIS SNAETIIRQT 240 TRGLSVWMGQ GSQGHEPLAA NNTTLQDQIH QFGPAVSSVG TLFGDPLVSC SNPPAPSDYQ 300 LNWVFGSKIS SNNAHEDQLT SSTTSLPLSD VKGGGTQLIN VPSLYSTQHH SHQTPSANMS 360 ATALLQKAAQ IGATSTDSSF LGSFGLKCSN NNGGQVQEGN KFCGLYCSNA MSRSHGSSVE 420 NPEADVPQMY PAAKRRHVQS SEEGAGRGGQ TRDFLGVGVQ TICHPSSING WI

Sequence ? help Back to Top

Protein Sequence Length: 472 aa Download sequence Send to blast

MAEEAISSGF VQNPISGGSD NPPAVKKKRN LPGTPDPEAE VIALSPKTLM ATNRFLCEIC  60
GKGFQRDQNL QLHRRGHNLP WKLKQRTSKE PRKRVYVCPE KSCVHNHPSR ALGDLTGIKK  120
HFCRKHGEKK WKCEKCSKRY AVQSDWKAHS KTCGTREYKC DCGTLFSRRD SFITHRAFCD  180
ALAEETARLN AASNISNSMA AGNINYHFIG TSLAPTMATQ PFPSVFKPIS SNAETIIRQT  240
TRGLSVWMGQ GSQGHEPLAA NNTTLQDQIH QFGPAVSSVG TLFGDPLVSC SNPPAPSDYQ  300
LNWVFGSKIS SNNAHEDQLT SSTTSLPLSD VKGGGTQLIN VPSLYSTQHH SHQTPSANMS  360
ATALLQKAAQ IGATSTDSSF LGSFGLKCSN NNGGQVQEGN KFCGLYCSNA MSRSHGSSVE  420
NPEADVPQMY PAAKRRHVQS SEEGAGRGGQ TRDFLGVGVQ TICHPSSING WI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	4e-37	127	194	3	70	Zinc finger protein JACKDAW
5b3h_F	4e-37	127	194	3	70	Zinc finger protein JACKDAW
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds to the DNA sequence 5'-CTTTTGTCC-3' (PubMed:21265895, PubMed:25929516). Regulates photoperiodic flowering by modulating sugar transport and metabolism (PubMed:21265895, PubMed:25929516). Regulates SUS1 and SUS4 (PubMed:21265895). Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:25829440). {ECO:0000269\|PubMed:21265895, ECO:0000269\|PubMed:25829440, ECO:0000269\|PubMed:25929516}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_015881278.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by 'SHORT-ROOT' (SHR)(PubMed:16640459). Strongly down-regulated by sugar deprivation, but not regulated by day-length. {ECO:0000269\|PubMed:16640459}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015881278.1	0.0	zinc finger protein NUTCRACKER-like
Refseq	XP_024928109.1	0.0	zinc finger protein NUTCRACKER-like
Swissprot	Q9FFH3	1e-157	IDD8_ARATH; Zinc finger protein NUTCRACKER
TrEMBL	A0A2N9FGW2	0.0	A0A2N9FGW2_FAGSY; Uncharacterized protein
STRING	EOX99537	0.0	(Theobroma cacao)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4626	29	51

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G44160.1	1e-149	C2H2-like zinc finger protein

Publications ? help Back to Top
Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Long Y, et al. In vivo FRET-FLIM reveals cell-type-specific protein interactions in Arabidopsis roots. Nature, 2017. 548(7665): p. 97-102 [PMID:28746306]