PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica

Family

MYB

Protein Properties

Length: 313aa MW: 35344.5 Da PI: 9.7418

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_013627188.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	51.2	2.9e-16	77	122	1	47
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 rg W + Ed +l+++v+q+G+ +W++Ia+++ gR++k+c++rw + XP_013627188.1 77 RGHWRPTEDAKLKELVAQFGPQNWNLIAHHLL-GRSGKSCRLRWCNQ 122 899**************************9.*********985 PP
2	Myb_DNA-binding	53.1	7.6e-17	129	173	1	47
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 ++++T+eE+ +l+ a++ +G++ W++I+r ++ gRt++ +k++w+ + XP_013627188.1 129 KKAFTEEEETRLLTAHRAYGNK-WSLISRFFP-GRTDNAVKNHWHVV 173 679*****************.*****.*********976 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	17.24	72	123	IPR017930	Myb domain
SMART	SM00717	2.9E-14	76	125	IPR001005	SANT/Myb domain
SuperFamily	SSF46689	1.46E-28	77	170	IPR009057	Homeodomain-like
Pfam	PF00249	1.1E-15	77	122	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	9.3E-26	78	130	IPR009057	Homeodomain-like
CDD	cd00167	7.05E-13	80	121	No hit	No description
PROSITE profile	PS51294	24.394	124	178	IPR017930	Myb domain
SMART	SM00717	6.9E-15	128	176	IPR001005	SANT/Myb domain
Pfam	PF00249	2.5E-14	129	172	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	3.4E-20	131	176	IPR009057	Homeodomain-like
CDD	cd00167	4.25E-11	131	174	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 313 aa Download sequence Send to blast
MDPKLIEKVL TGNKTIKLSR RFEEANNFGS PPNSHTNLSL ARNHLHNKSY SVLERGENEN 60 SFKRRGNNGM NKKLCSRGHW RPTEDAKLKE LVAQFGPQNW NLIAHHLLGR SGKSCRLRWC 120 NQLDPRINKK AFTEEEETRL LTAHRAYGNK WSLISRFFPG RTDNAVKNHW HVVMARRTRA 180 SERQQALHAP SGNAEMTVSS VYRYNRGGFF GRVAEGTLVN EADDDDGSAV STCTTELSLT 240 PPSSTHQPRF LHDDNTLASG KDGQCVQIAE VNGICSNKMD HQNHYTTTVS EREVEMKTKS 300 GFYIFDFLGV GAS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1a5j_A	2e-31	77	178	7	108	B-MYB
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in developing seeds. {ECO:0000269\|PubMed:23911125}.
Uniprot	TISSUE SPECIFICITY: Mostly expressed in flowers (at protein level) and siliques, and, to a lower extent, in roots, stems and leaves (PubMed:25343985). Expressed in embryos (e.g. heart and torpedo stages) and cotyledons, and, at low levels, in roots and inflorescence (PubMed:23911125). Accumulates specifically in root apical meristem quiescent center (QC) and vascular initial cells (PubMed:16581911, PubMed:24981610). {ECO:0000269\|PubMed:16581911, ECO:0000269\|PubMed:23911125, ECO:0000269\|PubMed:24981610, ECO:0000269\|PubMed:25343985}.

Functional Description ? help Back to Top
Source	Description
UniProt	Acts as a cell-specific local repressor of quiescent center (QC) self-renewal by cell divisions in the primary root. Counteracts brassinosteroid (BR)-mediated cell division in the QC cells (PubMed:24981610). Regulates maternally seed size, especially before the heart stage, promoting both endothelial cells expansion and cell number in the outer integument layer of the seed coat (PubMed:23911125). Modulates the expression of genes involved in cell wall metabolism such as cell division and expansion (PubMed:23911125, PubMed:24981610). Negative regulator of flowering via the repression of FT transcription (PubMed:25343985). {ECO:0000269\|PubMed:23911125, ECO:0000269\|PubMed:24981610, ECO:0000269\|PubMed:25343985}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_013627188.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Levels follow a circadian cycle with a progressive decrease during the day time (at protein level) (PubMed:25343985). Down-regulated by brassinosteroids (BRs) in a dose- and time-dependent manner. Repressed by BES1. Auto-activation of expression (PubMed:24981610). Targeted to 26S proteasomal degradation by the CULLIN3 (CUL3)-based E3 ligases CRL3(BPMs) (PubMed:25343985). {ECO:0000269\|PubMed:24981610, ECO:0000269\|PubMed:25343985}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_013627188.1	0.0	PREDICTED: transcription factor MYB23-like
Swissprot	Q6R053	1e-157	MYB56_ARATH; Transcription factor MYB56
TrEMBL	A0A0D3B1P6	0.0	A0A0D3B1P6_BRAOL; Uncharacterized protein
STRING	Bo3g012780.1	0.0	(Brassica oleracea)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM9977	18	36

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G17800.1	1e-146	myb domain protein 56

Publications ? help Back to Top
Chen L,Bernhardt A,Lee J,Hellmann H Identification of Arabidopsis MYB56 as a novel substrate for CRL3BPM E3 ligases. Mol Plant, 2015. [PMID:25343985] Frigola D,Caño-Delgado AI,Ibañes M Methods for Modeling Brassinosteroid-Mediated Signaling in Plant Development. Methods Mol. Biol., 2017. 1564: p. 103-120 [PMID:28124249] Espinosa-Ruiz A, et al. TOPLESS mediates brassinosteroid control of shoot boundaries and root meristem development in Arabidopsis thaliana. Development, 2017. 144(9): p. 1619-1628 [PMID:28320734] Jeong CY, et al. AtMyb56 Regulates Anthocyanin Levels via the Modulation of AtGPT2 Expression in Response to Sucrose in Arabidopsis. Mol. Cells, 2018. 41(4): p. 351-361 [PMID:29487277]