PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica

Family

C2H2

Protein Properties

Length: 261aa MW: 28746.7 Da PI: 9.6433

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_013618462.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	14.5	0.0001	102	124	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ykC+ Cgk F++ L H +H XP_013618462.1 102 YKCSVCGKAFPSYQALGGHKASH 124 9***********99999998887 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	2.4E-4	102	124	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Pfam	PF13912	1.6E-13	102	125	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	1.14E-8	102	124	No hit	No description
SMART	SM00355	0.0043	102	124	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.616	102	124	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	104	124	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	1.14E-8	152	179	No hit	No description
Pfam	PF13912	4.6E-13	157	181	IPR007087	Zinc finger, C2H2
PROSITE profile	PS50157	9.078	157	179	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.15	157	179	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	159	179	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 261 aa Download sequence Send to blast
MALEAMNSPS FTVRKDRIEA TEDDLMNDAV FMEPWLKRKR SKRQRSRSPS PSTSSSPPRS 60 RRPKSESQDL TEEEYLALCL LKLAKDKHSP RPQPQDSTKL SYKCSVCGKA FPSYQALGGH 120 KASHRIKPLT ADNSTSPIIA GEKHHSSATV PPSGKIHECS ICRKVFPTGQ ALGGHKRCHY 180 EGNLGGGSKT ISQSGSVSST VSEDRSNHVL IDLNLPALPE LSLHHNPVVD EEILSPLTGK 240 KPLLLTDRDQ VIKKEDLSLR I

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	35	42	LKRKRSKR
2	41	46	KRQRSR

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in roots, radicles, cotyledons, hypocotyls, leaf veins, stems, sepals, petals, stamens, placenta, funiculi and maturated seeds. {ECO:0000269\|PubMed:10806347, ECO:0000269\|PubMed:15333755, ECO:0000269\|PubMed:20619483}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional repressor involved in the inhibition of plant growth under abiotic stress conditions. Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner. Acts as a negative regulator of abscisic acid (ABA) signaling during seed germination. Probably involved in jasmonate (JA) early signaling response. May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade. May act as a positive regulator of leaf senescence. Has been identified as a suppressor of the deficiency of yeast snf4 mutant to grow on non-fermentable carbon source. {ECO:0000269\|PubMed:10929106, ECO:0000269\|PubMed:15333755, ECO:0000269\|PubMed:18216250, ECO:0000269\|PubMed:20619483, ECO:0000269\|PubMed:21852415, ECO:0000269\|PubMed:22709441}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_013618462.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By abscisic acid (ABA), ethylene, salt, cold, dehydration and the monovalent and divalent cations Li(+), Na(+), K(+), Cs(+), Ca(2+) and Mg(2+). {ECO:0000269\|PubMed:10806347, ECO:0000269\|PubMed:15333755, ECO:0000269\|PubMed:20619483, ECO:0000269\|PubMed:21852415}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_013618462.1	0.0	PREDICTED: zinc finger protein AZF2-like
Refseq	XP_022550878.1	0.0	zinc finger protein AZF2-like
Swissprot	Q9SSW2	1e-102	AZF2_ARATH; Zinc finger protein AZF2
TrEMBL	A0A0D3AC98	0.0	A0A0D3AC98_BRAOL; Uncharacterized protein
TrEMBL	A0A3P6FHW4	0.0	A0A3P6FHW4_BRAOL; Uncharacterized protein
STRING	Bo1g113530.1	0.0	(Brassica oleracea)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10272	18	29

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G19580.2	7e-86	zinc-finger protein 2

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Ortiz-Espín A, et al. Mitochondrial AtTrxo1 is transcriptionally regulated by AtbZIP9 and AtAZF2 and affects seed germination under saline conditions. J. Exp. Bot., 2017. 68(5): p. 1025-1038 [PMID:28184497]