PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_013588252.1

Organism

Brassica oleracea

Taxonomic ID

3712

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica

Family

bHLH

Protein Properties

Length: 201aa MW: 22848.6 Da PI: 9.3381

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_013588252.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	34.1	4.9e-11	2	50	4	55
HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +h ++Er RR+++N+ + Lr+l P + k+ + a+i ++e+Ik++q XP_013588252.1 2 SHIAVERTRRRQMNEHLKSLRSLTPCF---YIKRGDQASIIGGVIEFIKEMQ 50 89**********************9...9*****************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50888	14.056	1	49	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	6.12E-11	1	54	No hit	No description
SuperFamily	SSF47459	1.31E-14	1	67	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	2.3E-11	2	61	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	3.0E-8	2	50	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	1.1E-9	4	55	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009913	Biological Process	epidermal cell differentiation
GO:0010374	Biological Process	stomatal complex development
GO:0005634	Cellular Component	nucleus
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 201 aa Download sequence Send to blast
MSHIAVERTR RRQMNEHLKS LRSLTPCFYI KRGDQASIIG GVIEFIKEMQ QLVQVLESKK 60 RRKTLNRPSF LHDHQTLEPS ILAAATTRVP FNQIENVMTT STFKEVGSCC NSPHANVEAK 120 ISGSNVVLRV VSRRIEGQLV RIISVLEKLS FPVLHLNISS MEETVLYFFV VKIGLECHIS 180 LEELTFEVQK SFVPEVIVST N

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	58	62	KKRRK

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Strongly expressed in meristemoids and at lower levels in guard mother cells (GMCs) and guard cells. {ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267}.
Uniprot	TISSUE SPECIFICITY: Leaf epidermis and flowers. {ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:17183265}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata. {ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_013588252.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By UV, flagellin, and jasmonic acid (JA) treatments. {ECO:0000269\|PubMed:12679534}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF488580	0.0	AF488580.1 Arabidopsis thaliana clone bHLH045 putative bHLH transcription factor mRNA, partial sequence.
GenBank	DQ446639	0.0	DQ446639.1 Arabidopsis thaliana clone pENTR221-At3g06120 basic helix-loop-helix family protein (At3g06120) mRNA, complete cds.
GenBank	DQ653068	0.0	DQ653068.1 Arabidopsis thaliana clone 0000012753_0000009233 unknown mRNA.
GenBank	DQ863645	0.0	DQ863645.1 Arabidopsis thaliana helix-loop-helix protein (MUTE) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_013588252.1	1e-145	PREDICTED: transcription factor MUTE-like
Swissprot	Q9M8K6	1e-131	MUTE_ARATH; Transcription factor MUTE
TrEMBL	A0A0D3AFC9	1e-143	A0A0D3AFC9_BRAOL; Uncharacterized protein
STRING	Bo1g150080.1	1e-144	(Brassica oleracea)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7073	26	40

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G06120.1	1e-134	bHLH family protein

Publications ? help Back to Top
Casson S,Gray JE Influence of environmental factors on stomatal development. New Phytol., 2008. 178(1): p. 9-23 [PMID:18266617] Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Balcerowicz M,Ranjan A,Rupprecht L,Fiene G,Hoecker U Auxin represses stomatal development in dark-grown seedlings via Aux/IAA proteins. Development, 2014. 141(16): p. 3165-76 [PMID:25063454] de Marcos A, et al. Transcriptional profiles of Arabidopsis stomataless mutants reveal developmental and physiological features of life in the absence of stomata. Front Plant Sci, 2015. 6: p. 456 [PMID:26157447] Mahoney AK, et al. Functional analysis of the Arabidopsis thaliana MUTE promoter reveals a regulatory region sufficient for stomatal-lineage expression. Planta, 2016. 243(4): p. 987-98 [PMID:26748914] Klermund C, et al. LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls. Plant Cell, 2016. 28(3): p. 646-60 [PMID:26917680] Fu ZW,Wang YL,Lu YT,Yuan TT Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis. Plant Sci., 2016. 252: p. 282-289 [PMID:27717464] Qi X, et al. Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling. Elife, 2018. [PMID:28266915] Raissig MT, et al. Mobile MUTE specifies subsidiary cells to build physiologically improved grass stomata. Science, 2017. 355(6330): p. 1215-1218 [PMID:28302860] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han SK, et al. MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata. Dev. Cell, 2018. 45(3): p. 303-315.e5 [PMID:29738710]