PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_013583788.1
Organism
Brassica oleracea
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family bHLH
Protein Properties Length: 437aa    MW: 48579.3 Da    PI: 4.8599
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_013583788.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH36.11.2e-11259301754
                     HHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS
             HLH   7 erErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54 
                     ++ErrRR+++N+++  Lr+++Pk +      K++ a+iL  A++Y+k+L
  XP_013583788.1 259 MAERRRRKKLNDRLYMLRSVVPKiS------KMDRASILGDAIDYLKEL 301
                     79*********************66......****************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.866252301IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.05E-16255323IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.2E-14258307IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.8E-9258301IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.109.9E-16259315IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.55E-13259305No hitNo description
CDDcd048733.99E-7366426No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 437 aa     Download sequence    Send to blast
MNGDGVWLDD AGERSQAGYN DEPVPWVRNP EENWFNNSQP HDDSQNEFRF NNGGFPLNPS  60
ENLLLLLQQS IDSSSPFQHF TLDSATPQQQ QQQQYFLATK ACIASLLNVP TTTNNNNPFD  120
DFGFDSPSLG QLNQTPNSMS FPVMTSPPPE FLSSRSCNVF SPLEFEGLAS GVFENRAKVL  180
KPLEVLASSA SELTLFQKRA AMRESSSSKM CNSDSSSSEM RREVGDETSP GIVDIFNYES  240
DEHNNNKGKK KGMPAKNLMA ERRRRKKLND RLYMLRSVVP KISKMDRASI LGDAIDYLKE  300
LLQRINDLNT ELESTPSSSS GLTPSPQTLP YRVKEELCPS SSSLSSPKGE QARIEVKLRE  360
GKAVNIHMFS GRRPGLLLST MRALDDLGLD VQQAVISCFN GFALDVFRAE QCQEGHEVFP  420
EQIKAVLLDT AGYSGLL
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1248266KKKGMPAKNLMAERRRRKK
2260267ERRRRKKL
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems, and flowers. Broad expression within stomatal cell lineages of leaf epidermis, except in mature guard-cells. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:18641265}.
Functional Description ? help Back to Top
Source Description
UniProtMediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA (PubMed:18641265). Functions as a dimer with SPCH during stomatal initiation (PubMed:18641265, PubMed:28507175). {ECO:0000269|PubMed:18641265, ECO:0000269|PubMed:28507175}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_013583788.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAK1180111e-177AK118011.1 Arabidopsis thaliana At1g12860 mRNA for putative bHLH transcription factor (bHLH033), complete cds, clone: RAFL19-21-N13.
GenBankBT0053771e-177BT005377.1 Arabidopsis thaliana At1g12860 mRNA, complete cds.
GenBankEU3696701e-177EU369670.1 Arabidopsis thaliana bHLH protein (SCREAM2) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013583788.10.0PREDICTED: transcription factor SCREAM2
SwissprotQ9LPW30.0SCRM2_ARATH; Transcription factor SCREAM2
TrEMBLA0A0D3C9I70.0A0A0D3C9I7_BRAOL; Uncharacterized protein
STRINGBo5g016510.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM19522782
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G12860.11e-141bHLH family protein
Publications ? help Back to Top
  1. Tarasov VA,Khadeeva NV,Mel'nik VA,Ezhova TA,Shestakov SV
    The Atlg12860 gene of Arabidopsis thaliana determines cathelicidin-like antimicrobial activity.
    Dokl. Biol. Sci., 2009.
    [PMID:19760875]
  2. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Emmerstorfer A, et al.
    Over-expression of ICE2 stabilizes cytochrome P450 reductase in Saccharomyces cerevisiae and Pichia pastoris.
    Biotechnol J, 2015. 10(4): p. 623-35
    [PMID:25641738]
  5. Lee HG,Seo PJ
    The MYB96-HHP module integrates cold and abscisic acid signaling to activate the CBF-COR pathway in Arabidopsis.
    Plant J., 2015. 82(6): p. 962-77
    [PMID:25912720]
  6. Raissig MT,Abrash E,Bettadapur A,Vogel JP,Bergmann DC
    Grasses use an alternatively wired bHLH transcription factor network to establish stomatal identity.
    Proc. Natl. Acad. Sci. U.S.A., 2016. 113(29): p. 8326-31
    [PMID:27382177]
  7. Fu ZW,Wang YL,Lu YT,Yuan TT
    Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis.
    Plant Sci., 2016. 252: p. 282-289
    [PMID:27717464]
  8. de Marcos A, et al.
    A Mutation in the bHLH Domain of the SPCH Transcription Factor Uncovers a BR-Dependent Mechanism for Stomatal Development.
    Plant Physiol., 2017. 174(2): p. 823-842
    [PMID:28507175]