PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_013583773.1
Organism
Brassica oleracea
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 389aa    MW: 43832 Da    PI: 7.8418
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_013583773.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.73.9e-233297171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl+l+++   +++ l++++++L    v  +rRRiYDi+NVLe+++++++++kn+++wkg
  XP_013583773.1 32 RKQKSLGLLCTNFLALYNRHGIETIGLDDASSKL---GV--ERRRIYDIVNVLESVGVLTRRAKNQYTWKG 97
                    79*****************999************...**..****************************98 PP
2E2F_TDP79.43.2e-25164244171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL+lltq+f+kl+ +s+++i++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k++++w g
  XP_013583773.1 164 RREKSLGLLTQNFIKLFICSQATIISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtldSRKPAFKWLG 244
                     689**************************************999************************9999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-252898IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.15E-163195IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-283297IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.8E-203397IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.2E-23161245IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.2E-32164244IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.2E-20166244IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.61E-14166245IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 389 aa     Download sequence    Send to blast
MSDLPPEKTN MELSSSSSMP GPSSSLHHSY SRKQKSLGLL CTNFLALYNR HGIETIGLDD  60
ASSKLGVERR RIYDIVNVLE SVGVLTRRAK NQYTWKGFAA IPAALKELQE EGAKDTFHRF  120
YINENVKGSD DEDDEEESSS QPLSSSQTDT SKPSLPDSSK IDNRREKSLG LLTQNFIKLF  180
ICSQATIISL DEAAKLLLGD AHNTSIMRTK VRRLYDIANV LSSMNLIEKT HTLDSRKPAF  240
KWLGYNGEPT FTLSSDLMMQ AESKKRVFGT DLSNVSVKRS KTHESATERS LKMKHHAIAE  300
SSYNRIFDAH ESRHGSRGYE FGPFAPATGT YPTAPLEDSS KRAFDVENLV SDYRPSYQNQ  360
VLKDLFGHYM DAWKSWYSEV TQKNPSQHH
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-41312363228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_013583773.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013583773.10.0PREDICTED: E2F transcription factor-like E2FE
RefseqXP_013672120.20.0E2F transcription factor-like E2FE
RefseqXP_013680925.20.0E2F transcription factor-like E2FE
SwissprotQ8LSZ40.0E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A3N6RPN10.0A0A3N6RPN1_BRACR; Uncharacterized protein
STRINGBra033767.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM63042743
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.20.0DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]