PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Pedaliaceae; Sesamum

Family

C2H2

Protein Properties

Length: 463aa MW: 50536.8 Da PI: 8.7528

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_011100239.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.8	4.1e-05	55	75	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C++Cgk F r nL+ H r H XP_011100239.1 55 CEICGKGFQRDQNLQLHRRGH 75 *******************88 PP
2	zf-C2H2	12.9	0.00034	129	151	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k++ +s+ k H +t+ XP_011100239.1 129 WKCDKCSKRYAVQSDWKAHSKTC 151 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	4.0E-5	52	75	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.47E-6	52	75	No hit	No description
PROSITE profile	PS50157	11.489	53	75	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.076	53	75	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	55	75	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	2.1E-4	117	150	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.47E-6	124	149	No hit	No description
SMART	SM00355	140	129	149	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0005634	Cellular Component	nucleus
GO:0044212	Molecular Function	transcription regulatory region DNA binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 463 aa Download sequence Send to blast
MTEEVISIGS TANPVSGSNP PPAKKKRNLP GTPDPEAEVI ALSPQTLMAT NRFLCEICGK 60 GFQRDQNLQL HRRGHNLPWK LKQRSSKEVR KRVYVCPEKT CVHHHPSRAL GDLTGIKKHF 120 CRKHGEKKWK CDKCSKRYAV QSDWKAHSKT CGTREYKCDC GTIFSRRDSF ITHRAFCDAL 180 AEETARVTAA SHMNNHAASI NYHFIGSSLG QPAAVGQHFS SIFKPILSNT DQNIDPIPMG 240 RGLSLWNMGP GPVHDSIAKN LQDMQPMGVT VSSGAVNNFT HHVHSLINNP CSNPLPSTYN 300 QMNWDFGNKI SSNGDDHHDL TNNPLPVKEV SVPSLFSTQN QSHQPTTATI SATALLQKAA 360 EIGATTNDPS FLGNFGLKGS DNISVQDGNK LCGLYGTSSA TSGLGSDVES SVNDLSALNQ 420 MEMYSSKRRR VANGHEITGG ETRDFLGVGV QSICHPSSIN GWI

Sequence ? help Back to Top

Protein Sequence Length: 463 aa Download sequence Send to blast

MTEEVISIGS TANPVSGSNP PPAKKKRNLP GTPDPEAEVI ALSPQTLMAT NRFLCEICGK  60
GFQRDQNLQL HRRGHNLPWK LKQRSSKEVR KRVYVCPEKT CVHHHPSRAL GDLTGIKKHF  120
CRKHGEKKWK CDKCSKRYAV QSDWKAHSKT CGTREYKCDC GTIFSRRDSF ITHRAFCDAL  180
AEETARVTAA SHMNNHAASI NYHFIGSSLG QPAAVGQHFS SIFKPILSNT DQNIDPIPMG  240
RGLSLWNMGP GPVHDSIAKN LQDMQPMGVT VSSGAVNNFT HHVHSLINNP CSNPLPSTYN  300
QMNWDFGNKI SSNGDDHHDL TNNPLPVKEV SVPSLFSTQN QSHQPTTATI SATALLQKAA  360
EIGATTNDPS FLGNFGLKGS DNISVQDGNK LCGLYGTSSA TSGLGSDVES SVNDLSALNQ  420
MEMYSSKRRR VANGHEITGG ETRDFLGVGV QSICHPSSIN GWI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	4e-36	125	194	3	72	Zinc finger protein JACKDAW
5b3h_F	4e-36	125	194	3	72	Zinc finger protein JACKDAW
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	426	430	KRRRV

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440). Interacts with the SCR and MGP promoters (PubMed:21935722). Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). Positively involved in gibberellic acid (GA) signaling (PubMed:24821766). {ECO:0000269\|PubMed:17785527, ECO:0000269\|PubMed:21935722, ECO:0000269\|PubMed:24821766, ECO:0000269\|PubMed:25829440}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00125	DAP	Transfer from AT1G03840	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_011100239.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by the transcription factor JKD, and down-regulated by SHR, SCR and itself. {ECO:0000269\|PubMed:21935722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011100239.1	0.0	zinc finger protein NUTCRACKER
Swissprot	Q9ZWA6	1e-155	IDD3_ARATH; Zinc finger protein MAGPIE
TrEMBL	A0A061E4I0	0.0	A0A061E4I0_THECC; C2H2 and C2HC zinc fingers superfamily protein
STRING	EOX99537	0.0	(Theobroma cacao)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA103	24	350

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	1e-157	C2H2 family protein

Publications ? help Back to Top
Muñoz-Strale D,León G Identification of two highly specific pollen promoters using transcriptomic data. Plant Physiol. Biochem., 2014. 83: p. 292-9 [PMID:25208507] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755]