PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Pedaliaceae; Sesamum

Family

C2H2

Protein Properties

Length: 526aa MW: 57294.7 Da PI: 9.1194

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_011089318.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.1	3.2e-05	76	98	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 + C++C+k F r nL+ H r H XP_011089318.1 76 FICEICNKGFQRDQNLQLHRRGH 98 89*******************88 PP
2	zf-C2H2	11.8	0.00075	152	174	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC++C+k + +s+ k H + + XP_011089318.1 152 WKCEKCSKKYAVQSDWKAHSKIC 174 58*****************9876 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	1.4E-5	75	98	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	4.62E-7	75	98	No hit	No description
Pfam	PF12171	6.4E-5	76	98	IPR022755	Zinc finger, double-stranded RNA binding
SMART	SM00355	0.022	76	98	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.845	76	98	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	78	98	IPR007087	Zinc finger, C2H2
SMART	SM00355	100	117	147	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	1.7E-4	140	173	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	4.62E-7	147	172	No hit	No description
SMART	SM00355	140	152	172	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0005634	Cellular Component	nucleus
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 526 aa Download sequence Send to blast
MMSDDGLSSV PPSIRGGGGG GGGFIQDPNL ANPSNNINPN PNSNPSKRKR SLPGTPDPDA 60 EVIALSPKSL MATNRFICEI CNKGFQRDQN LQLHRRGHNL PWKLKQRTNK EVKKKVYICP 120 EKTCVHHDPS RALGDLTGIK KHFSRKHGEK KWKCEKCSKK YAVQSDWKAH SKICGTREYK 180 CDCGTLFSRK DSFITHRAFC DALAEESARF TPVPSANLSF RNELMNGGLN SLQNPGSSQF 240 SGIFRPELGG GLESGNHHQL NLDLQKPRLP LWLDNANSHH HPHLNNIGNP GSSNANFQLA 300 SSSSSSLPEL VQMATQNQWF SRGQQEATFA GGNINANNST SSSAIPRVLK EEQENKGNLS 360 EAISSLYYSN NHDTSNPPSA PMSATALLQK AAQMGSTRSS NSPIFGTGFG LMSSSFSNLG 420 NFSSLNQTRN VEVNQNLDKA DHQNLNGLQA DPGLLLGDID SSPLTPIPNS GKQSQSSGIE 480 AESSLTRDFL GVGGNHENRQ FLQENELAKF ASIGSAMDMS SHYRRN

Sequence ? help Back to Top

Protein Sequence Length: 526 aa Download sequence Send to blast

MMSDDGLSSV PPSIRGGGGG GGGFIQDPNL ANPSNNINPN PNSNPSKRKR SLPGTPDPDA  60
EVIALSPKSL MATNRFICEI CNKGFQRDQN LQLHRRGHNL PWKLKQRTNK EVKKKVYICP  120
EKTCVHHDPS RALGDLTGIK KHFSRKHGEK KWKCEKCSKK YAVQSDWKAH SKICGTREYK  180
CDCGTLFSRK DSFITHRAFC DALAEESARF TPVPSANLSF RNELMNGGLN SLQNPGSSQF  240
SGIFRPELGG GLESGNHHQL NLDLQKPRLP LWLDNANSHH HPHLNNIGNP GSSNANFQLA  300
SSSSSSLPEL VQMATQNQWF SRGQQEATFA GGNINANNST SSSAIPRVLK EEQENKGNLS  360
EAISSLYYSN NHDTSNPPSA PMSATALLQK AAQMGSTRSS NSPIFGTGFG LMSSSFSNLG  420
NFSSLNQTRN VEVNQNLDKA DHQNLNGLQA DPGLLLGDID SSPLTPIPNS GKQSQSSGIE  480
AESSLTRDFL GVGGNHENRQ FLQENELAKF ASIGSAMDMS SHYRRN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	4e-36	148	217	3	72	Zinc finger protein JACKDAW
5b3h_F	4e-36	148	217	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that, together with JKD, regulates tissue boundaries and asymmetric cell division in roots by a rapid up-regulation of 'SCARECROW' (SCR), thus controlling the nuclear localization of 'SHORT-ROOT' (SHR) and restricting its action (PubMed:25829440). Confines CYCD6 expression to the cortex-endodermis initial/daughter (CEI/CEID) tissues (PubMed:25829440). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). {ECO:0000269\|PubMed:24821766, ECO:0000269\|PubMed:25829440}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_011089318.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011089318.1	0.0	protein indeterminate-domain 9
Swissprot	Q944L3	1e-120	IDD9_ARATH; Zinc finger protein BALDIBIS
TrEMBL	A0A2Z7BLI8	0.0	A0A2Z7BLI8_9LAMI; Zinc finger protein JACKDAW-like
STRING	XP_009612448.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA103	24	350

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G45260.1	1e-105	C2H2-like zinc finger protein

Publications ? help Back to Top
Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755]