PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Arecales; Arecaceae; Arecoideae; Cocoseae; Elaeidinae; Elaeis

Family

E2F/DP

Protein Properties

Length: 471aa MW: 52095.3 Da PI: 4.794

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_010912366.1	genome	OG	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.3	2.3e-27	146	211	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++ll+++++gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg XP_010912366.1 146 RYDSSLGLLTKKFINLLKHAQDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 211 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	4.1E-29	144	213	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.4E-34	146	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.68E-17	146	209	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.8E-24	148	211	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	2.46E-50	222	329	No hit	No description
SuperFamily	SSF144074	1.26E-34	223	328	No hit	No description
Pfam	PF16421	1.7E-33	227	326	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 471 aa Download sequence Send to blast
MSGGRPAGNR SVQQRAGQIF PPLKRHPLFP LAKPPFVAPD EYHRFSAADG RRITPDDVSD 60 ALVIKTPLKR KPEQEDNEAA ESSEWTNSPG YAEAVTSPLL TPVSGRGGRN HGRSKVAKYS 120 KSGPLTPLSN AGSPSSNPLT PVGTCRYDSS LGLLTKKFIN LLKHAQDGIL DLNKAAETLE 180 VQKRRIYDIT NVLEGIGLIE KKLKNRIRWK GLDDLRPGVL DDDVSNLQAE VQNLTLQERS 240 LDDHISEMRE KLKVLTEDEN NQKWLYVTED DIKGLPCFQN ETLIAIKAPH GTTLEVPDPD 300 EAGEYPNRRY RIVLRSTMGP IDVYLVSQYE EKFEEMSGVE TPTRLPPASN SGSVENSTME 360 VVTEENRGKE MAPDVQDCQR MDSDPNASHD FVGGMMKIVP SDVDTDADYW LLSDAGVSIT 420 DMWKTAPEVQ WDAMGRFNPE DFIASNASTP RPETPPSGVI DAPSSTNSTQ R

Sequence ? help Back to Top

Protein Sequence Length: 471 aa Download sequence Send to blast

MSGGRPAGNR SVQQRAGQIF PPLKRHPLFP LAKPPFVAPD EYHRFSAADG RRITPDDVSD  60
ALVIKTPLKR KPEQEDNEAA ESSEWTNSPG YAEAVTSPLL TPVSGRGGRN HGRSKVAKYS  120
KSGPLTPLSN AGSPSSNPLT PVGTCRYDSS LGLLTKKFIN LLKHAQDGIL DLNKAAETLE  180
VQKRRIYDIT NVLEGIGLIE KKLKNRIRWK GLDDLRPGVL DDDVSNLQAE VQNLTLQERS  240
LDDHISEMRE KLKVLTEDEN NQKWLYVTED DIKGLPCFQN ETLIAIKAPH GTTLEVPDPD  300
EAGEYPNRRY RIVLRSTMGP IDVYLVSQYE EKFEEMSGVE TPTRLPPASN SGSVENSTME  360
VVTEENRGKE MAPDVQDCQR MDSDPNASHD FVGGMMKIVP SDVDTDADYW LLSDAGVSIT  420
DMWKTAPEVQ WDAMGRFNPE DFIASNASTP RPETPPSGVI DAPSSTNSTQ R

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-24	141	212	1	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010912366.1	0.0	transcription factor E2FB isoform X1
Swissprot	Q9FV71	1e-152	E2FB_ARATH; Transcription factor E2FB
TrEMBL	F5A665	0.0	F5A665_COCNU; E2F protein
STRING	XP_008784098.1	0.0	(Phoenix dactylifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-155	E2F transcription factor 1

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]