PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Cleomaceae; Tarenaya

Family

bHLH

Protein Properties

Length: 635aa MW: 68710.9 Da PI: 5.1046

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_010559309.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	40.9	3.8e-13	470	515	4	54
HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS HLH 4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 +h e+Er+RR+++N++f Lr l+P+ K++Ka+ L A+ YI++L XP_010559309.1 470 NHVEAERQRREKLNQRFYSLRALVPNV-----SKMDKASLLGDAISYINEL 515 799*********************6.....5*************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF14215	7.3E-54	73	259	IPR025610	Transcription factor MYC/MYB N-terminal
PROSITE profile	PS50888	17.606	466	515	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	8.9E-19	469	539	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.85E-15	469	520	No hit	No description
Gene3D	G3DSA:4.10.280.10	6.0E-19	470	536	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	1.3E-10	470	515	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	3.6E-17	472	521	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 635 aa Download sequence Send to blast
MTDYRLNGST NGTTASINLW TAADDSSVME TFIGSDHSSP WPPAPPPQQL SGDGGHPQQP 60 PTAAAQSQFN ETLQQRLQAL IEGAPETWTY AIFWQLSYDF DAAGGTALLG WGDGYYKGEE 120 DKGKSNIRCS PESAAEQEHR KRVIRELNAL ISGGAVAGAS EDAGDEEVTD TEWFFLVSMT 180 QSFLNGTGFP GQAFLNSRTI WLSGSDVLAG SGCERARQGQ IYGLHTLVCI PSENGVVELG 240 STEVIQQSSD LMEKVNTLFN FNSGGSEAGS WAFNLNPDQG ENDPAFWISE PTTGIESGNM 300 APTAAINNGN SNSHQLTKPG QFENGSSVEN PRQNPQGSSV DRDLNVSSSG LDQNGNYSDG 360 SRPKSGEILS FCGNKNGNGG GLSGKTRIVA GENKKKRSPV SKRSNNEEGI LSFTSGAALP 420 SSAAKSGDSD HSDVEASVYK EADSGRVVEP EKKPRKRGRK PANGREEPLN HVEAERQRRE 480 KLNQRFYSLR ALVPNVSKMD KASLLGDAIS YINELKSKVQ KAEFDKGELQ KQLRELRKGV 540 SGKDQKGLNQ DSGPSVETEI DVKIIGWDVM IRIQCSKKNH PGAKFMEALK ELDLEVNHAS 600 LSVVNDFMIE QATVKMGSRF FTQDQLKTAL MAKVS

Sequence ? help Back to Top

Protein Sequence Length: 635 aa Download sequence Send to blast

MTDYRLNGST NGTTASINLW TAADDSSVME TFIGSDHSSP WPPAPPPQQL SGDGGHPQQP  60
PTAAAQSQFN ETLQQRLQAL IEGAPETWTY AIFWQLSYDF DAAGGTALLG WGDGYYKGEE  120
DKGKSNIRCS PESAAEQEHR KRVIRELNAL ISGGAVAGAS EDAGDEEVTD TEWFFLVSMT  180
QSFLNGTGFP GQAFLNSRTI WLSGSDVLAG SGCERARQGQ IYGLHTLVCI PSENGVVELG  240
STEVIQQSSD LMEKVNTLFN FNSGGSEAGS WAFNLNPDQG ENDPAFWISE PTTGIESGNM  300
APTAAINNGN SNSHQLTKPG QFENGSSVEN PRQNPQGSSV DRDLNVSSSG LDQNGNYSDG  360
SRPKSGEILS FCGNKNGNGG GLSGKTRIVA GENKKKRSPV SKRSNNEEGI LSFTSGAALP  420
SSAAKSGDSD HSDVEASVYK EADSGRVVEP EKKPRKRGRK PANGREEPLN HVEAERQRRE  480
KLNQRFYSLR ALVPNVSKMD KASLLGDAIS YINELKSKVQ KAEFDKGELQ KQLRELRKGV  540
SGKDQKGLNQ DSGPSVETEI DVKIIGWDVM IRIQCSKKNH PGAKFMEALK ELDLEVNHAS  600
LSVVNDFMIE QATVKMGSRF FTQDQLKTAL MAKVS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4rqw_A	6e-90	66	262	1	195	Transcription factor MYC3
4rqw_B	6e-90	66	262	1	195	Transcription factor MYC3
4rs9_A	6e-90	66	262	1	195	Transcription factor MYC3
4yz6_A	6e-90	66	262	1	195	Transcription factor MYC3
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	451	459	KKPRKRGRK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in jasmonic acid (JA) gene regulation. With MYC2 and MYC3, controls additively subsets of JA-dependent responses. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the G-box (5'-CACGTG-3') of promoters. Activates multiple TIFY/JAZ promoters. {ECO:0000269\|PubMed:21321051, ECO:0000269\|PubMed:21335373, ECO:0000269\|PubMed:23943862}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_010559309.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By UV treatment. Not induced by jasmonic acid. {ECO:0000269\|PubMed:12679534, ECO:0000269\|PubMed:21335373}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010559309.1	0.0	PREDICTED: transcription factor MYC4-like
Swissprot	O49687	0.0	MYC4_ARATH; Transcription factor MYC4
TrEMBL	R0F4A8	0.0	R0F4A8_9BRAS; Uncharacterized protein
STRING	XP_010559309.1	0.0	(Tarenaya hassleriana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1265	28	96

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G17880.1	0.0	bHLH family protein

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Chico JM, et al. Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis. Plant Cell, 2014. 26(5): p. 1967-1980 [PMID:24824488] Gasperini D, et al. Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth. PLoS Genet., 2015. 11(6): p. e1005300 [PMID:26070206] Qi T, et al. Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis. Plant Cell, 2015. 27(6): p. 1634-49 [PMID:26071420] de Torres Zabala M, et al. Novel JAZ co-operativity and unexpected JA dynamics underpin Arabidopsis defence responses to Pseudomonas syringae infection. New Phytol., 2016. 209(3): p. 1120-34 [PMID:26428397] Yu J, et al. JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis. J. Exp. Bot., 2016. 67(3): p. 751-62 [PMID:26547795] Chen X,Huang H,Qi T,Liu B,Song S New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis. Plant Signal Behav, 2016. 11(2): p. e1135280 [PMID:26829586] Schmiesing A,Emonet A,Gouhier-Darimont C,Reymond P Arabidopsis MYC Transcription Factors Are the Target of Hormonal Salicylic Acid/Jasmonic Acid Cross Talk in Response to Pieris brassicae Egg Extract. Plant Physiol., 2016. 170(4): p. 2432-43 [PMID:26884488] Thatcher LF, et al. Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum. J. Exp. Bot., 2016. 67(8): p. 2367-86 [PMID:26896849] Gao C, et al. MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis. Plant Physiol. Biochem., 2016. 108: p. 63-70 [PMID:27415132] Gimenez-Ibanez S, et al. JAZ2 controls stomata dynamics during bacterial invasion. New Phytol., 2017. 213(3): p. 1378-1392 [PMID:28005270] Lian TF,Xu YP,Li LF,Su XD Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Cell Rep, 2017. 19(7): p. 1334-1342 [PMID:28514654] Wang H, et al. The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis. Mol Plant, 2017. 10(11): p. 1461-1464 [PMID:28827172] Song S, et al. MYC5 is Involved in Jasmonate-Regulated Plant Growth, Leaf Senescence and Defense Responses. Plant Cell Physiol., 2017. 58(10): p. 1752-1763 [PMID:29017003] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884]