PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010107141.1
Organism
Morus notabilis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Moraceae; Morus
Family bHLH
Protein Properties Length: 377aa    MW: 42900.4 Da    PI: 7.1801
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010107141.1genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH43.55.6e-14170221155
                     CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                     +r++h ++Er+RR+++N+ ++ Lr+l+P++   + ++ + a+i+  A++++k+L+
  XP_010107141.1 170 QRMTHIAVERNRRRQMNDHLNVLRSLMPTS---YIQRGDQASIVGGAIDFVKELE 221
                     79****************************...9******************995 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.28E-11168223No hitNo description
PROSITE profilePS5088815.605169220IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.36E-16169248IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.1E-13170233IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.9E-11170221IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003534.8E-10175226IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 377 aa     Download sequence    Send to blast
MPFLQMLQSV EISSSPSFLP LKEPTASFQT LLRLQHLKKQ QHQQQLYWEE GLFSGEYYNN  60
NINNIIMPCE METQIQAALE YNESCVTHDI VVELHGDPSV KSEAKDRYLQ YPVLISTSEC  120
NQEERPAGSK DEESKQTQNS KSISHHVVTR ERRKRKRTRP TKNKEEVETQ RMTHIAVERN  180
RRRQMNDHLN VLRSLMPTSY IQRGDQASIV GGAIDFVKEL EQLHESLEAQ KRMRKLEENN  240
NHPVSSSSSS SSSAAANPSS TGMFMSLSQY RTGPEEDINN NNNNNIGEEV RAENKSEAAD  300
IEVTVIQTHV NLKIQCPRRP GQLLKAIVAL EDLRLSILHL NITSSLATVL YSFNLKLVFG  360
RKLSCTFILA LIIGHDS
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1151156RRKRKR
2170181RMTHIAVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010107141.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024028485.10.0LOW QUALITY PROTEIN: transcription factor bHLH57
SwissprotQ56YJ85e-56FAMA_ARATH; Transcription factor FAMA
TrEMBLW9RVX50.0W9RVX5_9ROSA; Uncharacterized protein
STRINGXP_010107141.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF68943449
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G46810.12e-52bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]