PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_010103422.1
Organism
Morus notabilis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Moraceae; Morus
Family bHLH
Protein Properties Length: 356aa    MW: 40240.6 Da    PI: 8.8118
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_010103422.1genomeBGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH27.27.2e-09169213754
                     HHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
             HLH   7 erErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                     ++Er+RR+++N+ +  Lr+l P     + k+ + a+i   ++e+Ik++
  XP_010103422.1 169 AVERNRRRQMNEHLKVLRSLTPCF---YIKRGDQASIIGGVIEFIKEM 213
                     68*********************9...9******************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM001955.4E-4730166IPR020422Dual specificity protein phosphatase domain
SuperFamilySSF527991.06E-4230169IPR029021Protein-tyrosine phosphatase-like
PROSITE profilePS5005438.61830168IPR020422Dual specificity protein phosphatase domain
CDDcd001276.43E-5931164No hitNo description
Gene3DG3DSA:3.90.190.101.1E-4931172IPR029021Protein-tyrosine phosphatase-like
PfamPF007824.1E-3438165IPR000340Dual specificity phosphatase, catalytic domain
PROSITE profilePS5005613.98789148IPR000387Tyrosine specific protein phosphatases domain
PROSITE profilePS5088812.252162213IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.1E-9168219IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.32E-8169218No hitNo description
SuperFamilySSF474598.51E-13169232IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000104.2E-6169213IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.106.0E-9173225IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006470Biological Processprotein dephosphorylation
GO:0009913Biological Processepidermal cell differentiation
GO:0010374Biological Processstomatal complex development
GO:0005634Cellular Componentnucleus
GO:0008138Molecular Functionprotein tyrosine/serine/threonine phosphatase activity
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 356 aa     Download sequence    Send to blast
MDLADETLRE QFSALERVMA MSRRFNRDNL PSKIEEGLFL GSLKAARNKE ELKKLNITHI  60
LTVANYIKPL YPNEFFYKVI NDSQDADIKQ YFDECCNFID EAKRSGGAVL VHCIVGKSRS  120
VTVVVAYLMK KHGMSLSEAL EHVKSKRPIA SPNSGFISQL MEFEKYLLAV ERNRRRQMNE  180
HLKVLRSLTP CFYIKRGDQA SIIGGVIEFI KEMHQVLQSL ESKKRRKSLS PSPGPSPRPF  240
QRPLTPNCLD SPNLGSENFK ELGASCNSPA ADVEAKISGS NVVLKVISRR IPGQIAKIIS  300
VLERLSFEVL HLNISSMEDT VLYSFVIKIG LECQLSMEEL VLEVQQSIRS DNLYAE
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1yz4_A4e-28321809155dual specificity phosphatase-like 15 isoform a
1yz4_B4e-28321809155dual specificity phosphatase-like 15 isoform a
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1222226KKRRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor. Together with FMA and SPCH, regulates the stomata formation. Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells. Promotes the conversion of the leaf epidermis into stomata. {ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_010103422.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By UV, flagellin, and jasmonic acid (JA) treatments. {ECO:0000269|PubMed:12679534}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024025895.11e-133transcription factor MUTE
SwissprotQ9M8K61e-82MUTE_ARATH; Transcription factor MUTE
TrEMBLW9RL470.0W9RL47_9ROSA; Transcription factor MUTE
STRINGXP_010103422.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF112523036
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G06120.11e-73bHLH family protein
Publications ? help Back to Top
  1. Casson S,Gray JE
    Influence of environmental factors on stomatal development.
    New Phytol., 2008. 178(1): p. 9-23
    [PMID:18266617]
  2. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  3. Balcerowicz M,Ranjan A,Rupprecht L,Fiene G,Hoecker U
    Auxin represses stomatal development in dark-grown seedlings via Aux/IAA proteins.
    Development, 2014. 141(16): p. 3165-76
    [PMID:25063454]
  4. de Marcos A, et al.
    Transcriptional profiles of Arabidopsis stomataless mutants reveal developmental and physiological features of life in the absence of stomata.
    Front Plant Sci, 2015. 6: p. 456
    [PMID:26157447]
  5. Mahoney AK, et al.
    Functional analysis of the Arabidopsis thaliana MUTE promoter reveals a regulatory region sufficient for stomatal-lineage expression.
    Planta, 2016. 243(4): p. 987-98
    [PMID:26748914]
  6. Klermund C, et al.
    LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls.
    Plant Cell, 2016. 28(3): p. 646-60
    [PMID:26917680]
  7. Fu ZW,Wang YL,Lu YT,Yuan TT
    Nitric oxide is involved in stomatal development by modulating the expression of stomatal regulator genes in Arabidopsis.
    Plant Sci., 2016. 252: p. 282-289
    [PMID:27717464]
  8. Qi X, et al.
    Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling.
    Elife, 2018.
    [PMID:28266915]
  9. Raissig MT, et al.
    Mobile MUTE specifies subsidiary cells to build physiologically improved grass stomata.
    Science, 2017. 355(6330): p. 1215-1218
    [PMID:28302860]
  10. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  11. Han SK, et al.
    MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata.
    Dev. Cell, 2018. 45(3): p. 303-315.e5
    [PMID:29738710]