PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Moraceae; Morus

Family

C2H2

Protein Properties

Length: 457aa MW: 49750.4 Da PI: 9.2106

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_010093965.1	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.1	6.8e-05	8	28	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C+ Cgk F r nL+ H r H XP_010093965.1 8 CEVCGKGFQRDQNLQLHRRGH 28 *******************88 PP
2	zf-C2H2	12.9	0.00033	82	104	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k++ +s+ k H +t+ XP_010093965.1 82 WKCDKCSKRYAVQSDWKAHSKTC 104 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	2.5E-5	5	28	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.06E-6	5	28	No hit	No description
PROSITE profile	PS50157	11.51	6	28	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	8	28	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	2.1E-4	70	103	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.06E-6	77	102	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0005634	Cellular Component	nucleus
GO:0044212	Molecular Function	transcription regulatory region DNA binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 457 aa Download sequence Send to blast
MATNRFLCEV CGKGFQRDQN LQLHRRGHNL PWKLKQRSSK EPKKRVYVCP EKTCVHHHPS 60 RALGDLTGIK KHFCRKHGEK KWKCDKCSKR YAVQSDWKAH SKTCGTREYK CDCGTLFSRR 120 DSFITHRAFC DALAEETARV KAASDHMSYP MAAGNFSYHF TGASVGANMT QHFPSVFKPI 180 SSPNDVDATI GGGATTRGLS LWMGQGVSQL GQEAAMANNN VTSLQEIHQL GTVSSSGPTI 240 FRTTTDHHHP LSVSCSNPPP PSDYHHHLNW VLGSSTNKLS SNSSTISTTS TTHDQELTTT 300 SLPLRNNNNV KEAASSNNQL VSVPSLYSTQ HTSHHQTPPS SANMSATALL QKAAQIGATS 360 TDSSFLGSFG LKCNNNNSTQ VQEGSNKSCG LYGSNIISTT VESQEGDHLL QIYRPAKRRH 420 VQGSEEGTTG GGAGQTRDFL GVGVQAICHP SSINGWI

Sequence ? help Back to Top

Protein Sequence Length: 457 aa Download sequence Send to blast

MATNRFLCEV CGKGFQRDQN LQLHRRGHNL PWKLKQRSSK EPKKRVYVCP EKTCVHHHPS  60
RALGDLTGIK KHFCRKHGEK KWKCDKCSKR YAVQSDWKAH SKTCGTREYK CDCGTLFSRR  120
DSFITHRAFC DALAEETARV KAASDHMSYP MAAGNFSYHF TGASVGANMT QHFPSVFKPI  180
SSPNDVDATI GGGATTRGLS LWMGQGVSQL GQEAAMANNN VTSLQEIHQL GTVSSSGPTI  240
FRTTTDHHHP LSVSCSNPPP PSDYHHHLNW VLGSSTNKLS SNSSTISTTS TTHDQELTTT  300
SLPLRNNNNV KEAASSNNQL VSVPSLYSTQ HTSHHQTPPS SANMSATALL QKAAQIGATS  360
TDSSFLGSFG LKCNNNNSTQ VQEGSNKSCG LYGSNIISTT VESQEGDHLL QIYRPAKRRH  420
VQGSEEGTTG GGAGQTRDFL GVGVQAICHP SSINGWI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	1e-35	78	146	3	71	Zinc finger protein JACKDAW
5b3h_F	1e-35	78	146	3	71	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440). Interacts with the SCR and MGP promoters (PubMed:21935722). Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). Positively involved in gibberellic acid (GA) signaling (PubMed:24821766). {ECO:0000269\|PubMed:17785527, ECO:0000269\|PubMed:21935722, ECO:0000269\|PubMed:24821766, ECO:0000269\|PubMed:25829440}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00125	DAP	Transfer from AT1G03840	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_010093965.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by the transcription factor JKD, and down-regulated by SHR, SCR and itself. {ECO:0000269\|PubMed:21935722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	-	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010093965.2	0.0	zinc finger protein MAGPIE
Swissprot	Q9ZWA6	1e-130	IDD3_ARATH; Zinc finger protein MAGPIE
TrEMBL	W9QUZ5	0.0	W9QUZ5_9ROSA; Zinc finger protein MAGPIE
STRING	XP_010093965.1	0.0	(Morus notabilis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4626	29	51

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.2	1e-125	C2H2 family protein

Link Out ? help Back to Top
Entrez Gene	21393821

Publications ? help Back to Top
Muñoz-Strale D,León G Identification of two highly specific pollen promoters using transcriptomic data. Plant Physiol. Biochem., 2014. 83: p. 292-9 [PMID:25208507] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755]