PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Moraceae; Morus

Family

C2H2

Protein Properties

Length: 502aa MW: 55149.6 Da PI: 9.1928

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_010090785.1	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	17.2	1.4e-05	6	28	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H XP_010090785.1 6 FVCEICNKGFQRDQNLQLHRRGH 28 89*******************88 PP
2	zf-C2H2	15.6	4.5e-05	82	104	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k + +s+ k H++t+ XP_010090785.1 82 WKCDKCSKKYAVQSDWKAHQKTC 104 58*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	5.16E-8	5	28	No hit	No description
Gene3D	G3DSA:3.30.160.60	1.7E-5	5	28	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.017	6	28	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.949	6	28	IPR007087	Zinc finger, C2H2
Pfam	PF12171	8.0E-5	6	28	IPR022755	Zinc finger, double-stranded RNA binding
PROSITE pattern	PS00028	0	8	28	IPR007087	Zinc finger, C2H2
SMART	SM00355	98	47	77	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	5.8E-5	70	103	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	5.16E-8	77	103	No hit	No description
SMART	SM00355	94	82	102	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 502 aa Download sequence Send to blast
MATNRFVCEI CNKGFQRDQN LQLHRRGHNL PWKLRQRTTT ETKKRVYICP EPTCVHHNPA 60 RALGDLTGIK KHFSRKHGEK KWKCDKCSKK YAVQSDWKAH QKTCGTREYK CDCGTIFSRR 120 DSFITHRAFC DALAEENNKV NQGLTTNNNV GPNDLHVQMP DQLMPSMPMM STTTTTTTEF 180 LNNTPTTFDP KSPLKPVHPG QDLMPLPFKS MINMAAAGSG MFSSTSPVLF GSPKSISSAS 240 SNLQLCSSNS PGFTNYLQDS KNGCTGQSPG SAHMSATALL QKAAQMGATA SSSTMNSPMT 300 QKSFVSSMAG PDHHLSAGNV YDHQRHHQTN LVGINGHGFS NTRSSTNTTT TQQEMSQMFD 360 PNTSGGSMAN HDHNLGINMY GQILMGSGGG LELQEENGTN NNNNSSVVLQ GKGGLERSPS 420 TGASRFGRGG GDRIVVDFMG IGESRGASSL HEQQRLDQLE AMRSVQQQQQ RLPIINHINP 480 FHQHQQQQQL SHGDSIESWT RP

Sequence ? help Back to Top

Protein Sequence Length: 502 aa Download sequence Send to blast

MATNRFVCEI CNKGFQRDQN LQLHRRGHNL PWKLRQRTTT ETKKRVYICP EPTCVHHNPA  60
RALGDLTGIK KHFSRKHGEK KWKCDKCSKK YAVQSDWKAH QKTCGTREYK CDCGTIFSRR  120
DSFITHRAFC DALAEENNKV NQGLTTNNNV GPNDLHVQMP DQLMPSMPMM STTTTTTTEF  180
LNNTPTTFDP KSPLKPVHPG QDLMPLPFKS MINMAAAGSG MFSSTSPVLF GSPKSISSAS  240
SNLQLCSSNS PGFTNYLQDS KNGCTGQSPG SAHMSATALL QKAAQMGATA SSSTMNSPMT  300
QKSFVSSMAG PDHHLSAGNV YDHQRHHQTN LVGINGHGFS NTRSSTNTTT TQQEMSQMFD  360
PNTSGGSMAN HDHNLGINMY GQILMGSGGG LELQEENGTN NNNNSSVVLQ GKGGLERSPS  420
TGASRFGRGG GDRIVVDFMG IGESRGASSL HEQQRLDQLE AMRSVQQQQQ RLPIINHINP  480
FHQHQQQQQL SHGDSIESWT RP

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	3e-34	78	148	3	72	Zinc finger protein JACKDAW
5b3h_F	3e-34	78	148	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_010090785.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010090785.2	0.0	protein indeterminate-domain 2
Swissprot	Q9SCQ6	3e-95	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	W9R8A0	0.0	W9R8A0_9ROSA; Zinc finger protein MAGPIE
STRING	XP_010090785.1	0.0	(Morus notabilis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G50700.1	8e-85	indeterminate(ID)-domain 2

Link Out ? help Back to Top
Entrez Gene	21392407

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]