PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

ARR-B

Protein Properties

Length: 678aa MW: 74836 Da PI: 6.2773

Description

ARR-B family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_009615647.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	92.6	3.2e-29	216	269	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 kpr++W+ eLH++Fv+av+qL G++kA+Pk+ilelm+v+gLt+e+v+SHLQkYRl XP_009615647.1 216 KPRVVWSVELHQQFVQAVNQL-GIDKAVPKKILELMNVPGLTRENVASHLQKYRL 269 79*****************.******************************8 PP
2	Response_reg	74.6	3.7e-25	35	143	1	109
EEEESSSHHHHHHHHHHHHHTTCEEEEEESSHHHHHHHHHHHH..ESEEEEESSCTTSEHHHHHHHHHHHTTTSEEEEEESTTTHHHHHHHHHTT CS Response_reg 1 vlivdDeplvrellrqalekegyeevaeaddgeealellkekd..pDlillDiempgmdGlellkeireeepklpiivvtahgeeedalealkaG 93 vl+vdD+p+ +++l+++l + +y ev+ +e+al ll+e++ +D+++ D+ mp+mdG++ll++ e +lp+i+++a ++++ + + + G XP_009615647.1 35 VLVVDDDPTCLRILEKMLWNCHY-EVTKSNRAESALSLLRENRngFDIVISDVHMPDMDGFKLLEHVGLEM-DLPVIMMSADDSKDVVMKGVTHG 127 89*******************.***********99999*******************6644.8****************** PP ESEEEESS--HHHHHH CS Response_reg 94 akdflsKpfdpeelvk 109 a d+l Kp+ +e+l + XP_009615647.1 128 ACDYLIKPVRIEALKN 143 **********9986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PIRSF	PIRSF036392	1.9E-181	11	669	IPR017053	Response regulator B-type, plant
SuperFamily	SSF52172	3.7E-35	32	156	IPR011006	CheY-like superfamily
Gene3D	G3DSA:3.40.50.2300	2.2E-41	32	156	No hit	No description
SMART	SM00448	7.3E-28	33	145	IPR001789	Signal transduction response regulator, receiver domain
PROSITE profile	PS50110	41.193	34	149	IPR001789	Signal transduction response regulator, receiver domain
Pfam	PF00072	1.5E-22	35	143	IPR001789	Signal transduction response regulator, receiver domain
CDD	cd00156	3.67E-26	36	149	No hit	No description
PROSITE profile	PS51294	11.2	213	272	IPR017930	Myb domain
SuperFamily	SSF46689	8.51E-21	214	273	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	1.4E-30	215	274	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	1.7E-25	216	269	IPR006447	Myb domain, plants
Pfam	PF00249	2.0E-8	218	268	IPR001005	SANT/Myb domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000160	Biological Process	phosphorelay signal transduction system
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 678 aa Download sequence Send to blast
MNLGVGSVVK NMSGASCSVS WKSNDNNQFP AGLRVLVVDD DPTCLRILEK MLWNCHYEVT 60 KSNRAESALS LLRENRNGFD IVISDVHMPD MDGFKLLEHV GLEMDLPVIM MSADDSKDVV 120 MKGVTHGACD YLIKPVRIEA LKNIWQHVIR KKKHEWKDKD FDQSATAEAG DRQQKPPEDV 180 DYSSSANEGG NWKSSKRRKE EEDETEERDD SSSLKKPRVV WSVELHQQFV QAVNQLGIDK 240 AVPKKILELM NVPGLTRENV ASHLQKYRLY LRRLSGVSQH PNGLNNSFMG HPEATYGMSS 300 FNGLELQALA ATGQLPAQSL ATLQAAALGR SATKAAISMP LVDQRNLFSF ENPKLRFPEG 360 QQQLNNSNKQ INLLHGIPTT MEPKQLADLH QSSHSPSFVA MNMQGNSRVQ QNNTLLMHMS 420 QQQQQQPSRA QMLNETNNGS QVSRPPLSMS QQPLSSNGIP GAVLSRSGGI VANVRGPVYS 480 PVSQASPMVD FSLNQNTELQ NNSFPLVSSD SGMSTMTSKR MLQEEVNSDI RRSRGFPSGY 540 NMFDELHQQK SQDWGLSSVG STFDASHHST IPGTLDISPS MLVQQGISSM KRNGQNGISP 600 ISNAFSSREE SGNVNPMGGN LLTVKAEQLP DASYQSSFFP DQFGQDDLMS ALLKQQESVG 660 PVETEFGFDG YALDNLPV

Sequence ? help Back to Top

Protein Sequence Length: 678 aa Download sequence Send to blast

MNLGVGSVVK NMSGASCSVS WKSNDNNQFP AGLRVLVVDD DPTCLRILEK MLWNCHYEVT  60
KSNRAESALS LLRENRNGFD IVISDVHMPD MDGFKLLEHV GLEMDLPVIM MSADDSKDVV  120
MKGVTHGACD YLIKPVRIEA LKNIWQHVIR KKKHEWKDKD FDQSATAEAG DRQQKPPEDV  180
DYSSSANEGG NWKSSKRRKE EEDETEERDD SSSLKKPRVV WSVELHQQFV QAVNQLGIDK  240
AVPKKILELM NVPGLTRENV ASHLQKYRLY LRRLSGVSQH PNGLNNSFMG HPEATYGMSS  300
FNGLELQALA ATGQLPAQSL ATLQAAALGR SATKAAISMP LVDQRNLFSF ENPKLRFPEG  360
QQQLNNSNKQ INLLHGIPTT MEPKQLADLH QSSHSPSFVA MNMQGNSRVQ QNNTLLMHMS  420
QQQQQQPSRA QMLNETNNGS QVSRPPLSMS QQPLSSNGIP GAVLSRSGGI VANVRGPVYS  480
PVSQASPMVD FSLNQNTELQ NNSFPLVSSD SGMSTMTSKR MLQEEVNSDI RRSRGFPSGY  540
NMFDELHQQK SQDWGLSSVG STFDASHHST IPGTLDISPS MLVQQGISSM KRNGQNGISP  600
ISNAFSSREE SGNVNPMGGN LLTVKAEQLP DASYQSSFFP DQFGQDDLMS ALLKQQESVG  660
PVETEFGFDG YALDNLPV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1irz_A	3e-21	212	275	1	64	ARR10-B
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Regulates SHY2 by binding to its promoter (PubMed:19039136). Involved in the root-meristem size determination through the regulation of cell differentiation (PubMed:17363254). {ECO:0000269\|PubMed:11574878, ECO:0000269\|PubMed:11691951, ECO:0000269\|PubMed:17363254, ECO:0000269\|PubMed:19039136}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by gibberellin. {ECO:0000269\|PubMed:20605455}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	JF412542	0.0	JF412542.1 Nicotiana tabacum RRB2 type-b response regulator mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009615647.1	0.0	PREDICTED: two-component response regulator ARR2-like
Swissprot	Q940D0	0.0	ARR1_ARATH; Two-component response regulator ARR1
TrEMBL	A0A1S4BF24	0.0	A0A1S4BF24_TOBAC; Two-component response regulator
STRING	XP_009615647.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA3191	24	50

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G16857.2	1e-163	response regulator 1

Publications ? help Back to Top
Bürkle L,Meyer S,Dortay H,Lehrach H,Heyl A In vitro recombination cloning of entire cDNA libraries in Arabidopsis thaliana and its application to the yeast two-hybrid system. Funct. Integr. Genomics, 2005. 5(3): p. 175-83 [PMID:15714319] Moubayidin L, et al. Spatial coordination between stem cell activity and cell differentiation in the root meristem. Dev. Cell, 2013. 26(4): p. 405-15 [PMID:23987513] Takahashi N, et al. Cytokinins control endocycle onset by promoting the expression of an APC/C activator in Arabidopsis roots. Curr. Biol., 2013. 23(18): p. 1812-7 [PMID:24035544] Kurepa J,Li Y,Perry SE,Smalle JA Ectopic expression of the phosphomimic mutant version of Arabidopsis response regulator 1 promotes a constitutive cytokinin response phenotype. BMC Plant Biol., 2014. 14: p. 28 [PMID:24423196] Cortleven A, et al. A novel protective function for cytokinin in the light stress response is mediated by the Arabidopsis histidine kinase2 and Arabidopsis histidine kinase3 receptors. Plant Physiol., 2014. 164(3): p. 1470-83 [PMID:24424319] Marín-de la Rosa N, et al. Genome Wide Binding Site Analysis Reveals Transcriptional Coactivation of Cytokinin-Responsive Genes by DELLA Proteins. PLoS Genet., 2015. 11(7): p. e1005337 [PMID:26134422] D'Alessandro S,Golin S,Hardtke CS,Lo Schiavo F,Zottini M The co-chaperone p23 controls root development through the modulation of auxin distribution in the Arabidopsis root meristem. J. Exp. Bot., 2015. 66(16): p. 5113-22 [PMID:26163704] Jiang L, et al. Strigolactones spatially influence lateral root development through the cytokinin signaling network. J. Exp. Bot., 2016. 67(1): p. 379-89 [PMID:26519957] Moubayidin L, et al. A SCARECROW-based regulatory circuit controls Arabidopsis thaliana meristem size from the root endodermis. Planta, 2016. 243(5): p. 1159-68 [PMID:26848984] Muraro D, et al. A multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of Arabidopsis thaliana. J. Theor. Biol., 2016. 404: p. 182-205 [PMID:27157127] Cortleven A, et al. Cytokinin Regulates the Etioplast-Chloroplast Transition through the Two-Component Signaling System and Activation of Chloroplast-Related Genes. Plant Physiol., 2016. 172(1): p. 464-78 [PMID:27388681] Kobayashi K, et al. Shoot Removal Induces Chloroplast Development in Roots via Cytokinin Signaling. Plant Physiol., 2017. 173(4): p. 2340-2355 [PMID:28193764] Zhang TQ, et al. A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration. Plant Cell, 2017. 29(5): p. 1073-1087 [PMID:28389585] Kushwah S,Laxmi A The interaction between glucose and cytokinin signaling in controlling Arabidopsis thaliana seedling root growth and development. Plant Signal Behav, 2017. 12(5): p. e1312241 [PMID:28467152] Meng WJ, et al. Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation of WUSCHEL. Plant Cell, 2017. 29(6): p. 1357-1372 [PMID:28576846] Kobayashi K,Iwase A Simultaneous but spatially different regulation of non-photosynthetic callus formation and photosynthetic root development after shoot removal. Plant Signal Behav, 2017. 12(6): p. e1338999 [PMID:28594268] Liu B,De Storme N,Geelen D Cold interferes with male meiotic cytokinesis in Arabidopsis thaliana independently of the AHK2/3-AHP2/3/5 cytokinin signaling module. Cell Biol. Int., 2017. 41(8): p. 879-889 [PMID:28618065] Zhang F,May A,Irish VF Type-B ARABIDOPSIS RESPONSE REGULATORs Directly Activate WUSCHEL. Trends Plant Sci., 2017. 22(10): p. 815-817 [PMID:28886911] Yan Z, et al. Type B Response Regulators Act As Central Integrators in Transcriptional Control of the Auxin Biosynthesis Enzyme TAA1. Plant Physiol., 2017. 175(3): p. 1438-1454 [PMID:28931628] Rong XF, et al. Type-B ARRs Control Carpel Regeneration Through Mediating AGAMOUS Expression in Arabidopsis. Plant Cell Physiol., 2018. 59(4): p. 756-764 [PMID:29186581] Bustillo-Avendaño E, et al. Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis. Plant Physiol., 2018. 176(2): p. 1709-1727 [PMID:29233938] Waldie T,Leyser O Cytokinin Targets Auxin Transport to Promote Shoot Branching. Plant Physiol., 2018. 177(2): p. 803-818 [PMID:29717021]