PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009143621.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 481aa    MW: 52212.2 Da    PI: 4.5802
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009143621.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.24.3e-26160225171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++++g+++ln++a++L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
  XP_009143621.1 160 RYDSSLGLLTKKFVNLIKQAKDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPLKNRILWKG 225
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.3E-28156227IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-32160225IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.9E-16160223IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023197.6E-23162225IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.37E-33238342No hitNo description
CDDcd146603.12E-49238342No hitNo description
PfamPF164216.0E-33242340IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 481 aa     Download sequence    Send to blast
MSGGVRSSPG PSHQPPPPPS SSAASVPVVP PISRHLAFAS TKPPFHPSDN YHRFTPSHLT  60
NNLVNGCGGL VDREEDAVVL RSPSRKRKTT MDVVTTTTSS TSNGFTSSDG FTSSPCRTPV  120
SAKGGRVNIK SKSKVNQSIP QTPISNIGSP ATLTPSGSCR YDSSLGLLTK KFVNLIKQAK  180
DGMLDLNKAA ETLEVQKRRI YDITNVLEGI DLIEKPLKNR ILWKGVDASG PGDVDADVSD  240
VQAEIENLSL EEQALDNQIR ETEQRLRDLS ENEKNQKWLF VTEEDIKSLP GFQNQTLIAV  300
KAPHGTTLEV PDPDEGVGHP QRRYRIILRS TMGPIDVYLV SEFEEKFEDT NGPAEPPPPL  360
CLPIASCSGS TENHDIEALT ADNTGTAIED QLSQVHAHAQ PGETSDLNYL EEQVGGMLKI  420
TPSDVENDDT DYWLLSNADI SMTDIWKTDS GIDWDYGIAD VSTPPPMIGD ISPTAIDSIP  480
R
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-23155226274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
18388SRKRKT
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Bra.298646e-85root
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_009143621.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankJN9429840.0JN942984.1 Brassica juncea E2F transcription factor (E2Fa) mRNA, partial cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009143621.10.0PREDICTED: transcription factor E2FA-like isoform X1
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLM4CM680.0M4CM68_BRARP; Uncharacterized protein
STRINGBra005305.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]