PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009133061.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family E2F/DP
Protein Properties Length: 471aa    MW: 51545.4 Da    PI: 4.555
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009133061.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP81.28.9e-26154219171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r+++sL+llt+kf++l++++e+g+++ln++a+ L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
  XP_009133061.1 154 RYDSSLGLLTKKFVNLIKQAEDGMLDLNKAAEVL---EV--QKRRIYDITNVLEGIDLIEKPFKNRILWKG 219
                     6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.4E-27150221IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.58E-16154217IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.5E-32154219IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-22156219IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146605.73E-48232336No hitNo description
SuperFamilySSF1440744.45E-32232336No hitNo description
PfamPF164211.4E-32235334IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 471 aa     Download sequence    Send to blast
MSGGVRPSPG HSQPPPSSSN PVVPPIRRHL AFASTKPPFH PSDYRRFTPS YDSSSLCGIV  60
DREEDAVVLR SPSRKRKSMM DVVTTTTTTS NSNGFTSTGS TSIHNSPCLT PVSAKGGRVN  120
TKSRAKGTQS LPQTPISNAV VGSPATLTPS GSCRYDSSLG LLTKKFVNLI KQAEDGMLDL  180
NKAAEVLEVQ KRRIYDITNV LEGIDLIEKP FKNRILWKGV DASRPGDVDA DVSVLHAEIE  240
NLNLEEQALD SQIRETEERL RDLSENEKNQ KWLFVTEEDI KSLPGFQNQT LIAVKAPHGT  300
TLEVPDPDEA GDLPQRRYRI ILRSTMGPID VYLVSEFEDT NGSVAPPACL PPIASCSGST  360
ENHDIEALTL DNTETTIEHQ MSQDHEHAQP GDTSDLNYLQ EQVGGMLKIT PSDIENDDTD  420
YWLLSNAEIS MTDIWNTDSG IDWDYGIADV STPPPVMGEE IAPVAIDSKP R
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A4e-22149220274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
17277SRKRKS
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543}.
UniprotTISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269|PubMed:11108847, ECO:0000269|PubMed:11889041}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_009133061.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009133061.10.0PREDICTED: transcription factor E2FA-like isoform X1
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLM4E2P60.0M4E2P6_BRARP; Uncharacterized protein
STRINGBra023047.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]