PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus

Family

C2H2

Protein Properties

Length: 466aa MW: 51066.2 Da PI: 8.9129

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_008229114.1	genome	BGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.7	4.1e-05	64	84	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C++Cgk F r nL+ H r H XP_008229114.1 64 CEICGKGFQRDQNLQLHRRGH 84 *******************88 PP
2	zf-C2H2	12.9	0.00034	138	160	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k++ +s+ k H +t+ XP_008229114.1 138 WKCDKCSKRYAVQSDWKAHSKTC 160 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	4.0E-5	61	84	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.54E-6	61	84	No hit	No description
SMART	SM00355	0.076	62	84	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	11.489	62	84	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	64	84	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	2.2E-4	126	159	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.54E-6	133	158	No hit	No description
SMART	SM00355	140	138	158	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0005634	Cellular Component	nucleus
GO:0044212	Molecular Function	transcription regulatory region DNA binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 466 aa Download sequence Send to blast
MALNEESIPP MNGFVQDPAA GSISPPPPPP PAKKKRNLPG NPDPEAEVIA LSPKTLMATN 60 RFLCEICGKG FQRDQNLQLH RRGHNLPWKL KQRTNKEPRK RVYVCPEKSC VHHHPSRALG 120 DLTGIKKHFC RKHGEKKWKC DKCSKRYAVQ SDWKAHSKTC GTREYKCDCG TLFSRRDSFI 180 THRAFCDALA EETARVNAAS NMNNIPMGGN INYQYMGYSI GAVAGPNNNI MAQQYFSSIF 240 KPMISTPNNI DDEASRGLSI WMMGGNNNYN NNKNHDHHRH CPPPSDYDQI NNWVVGNKQL 300 ISSPSPYSIS NSNAPHHQES ITCTSTTTSS CSSSSLALIS NNIISDVPSL YSSKMSATAL 360 LQKAAQIGST TSSEAPLMGS FGINNISKVC GLYGVTSPDD HGHDHHAKRR SIQNCSAATT 420 TTTNDHHHQQ ETIAAGGGGG QTRDFLGVGV HAICHSSSPS INGYWT

Sequence ? help Back to Top

Protein Sequence Length: 466 aa Download sequence Send to blast

MALNEESIPP MNGFVQDPAA GSISPPPPPP PAKKKRNLPG NPDPEAEVIA LSPKTLMATN  60
RFLCEICGKG FQRDQNLQLH RRGHNLPWKL KQRTNKEPRK RVYVCPEKSC VHHHPSRALG  120
DLTGIKKHFC RKHGEKKWKC DKCSKRYAVQ SDWKAHSKTC GTREYKCDCG TLFSRRDSFI  180
THRAFCDALA EETARVNAAS NMNNIPMGGN INYQYMGYSI GAVAGPNNNI MAQQYFSSIF  240
KPMISTPNNI DDEASRGLSI WMMGGNNNYN NNKNHDHHRH CPPPSDYDQI NNWVVGNKQL  300
ISSPSPYSIS NSNAPHHQES ITCTSTTTSS CSSSSLALIS NNIISDVPSL YSSKMSATAL  360
LQKAAQIGST TSSEAPLMGS FGINNISKVC GLYGVTSPDD HGHDHHAKRR SIQNCSAATT  420
TTTNDHHHQQ ETIAAGGGGG QTRDFLGVGV HAICHSSSPS INGYWT

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	6e-37	134	203	3	72	Zinc finger protein JACKDAW
5b3h_F	6e-37	134	203	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440). Interacts with the SCR and MGP promoters (PubMed:21935722). Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). Positively involved in gibberellic acid (GA) signaling (PubMed:24821766). {ECO:0000269\|PubMed:17785527, ECO:0000269\|PubMed:21935722, ECO:0000269\|PubMed:24821766, ECO:0000269\|PubMed:25829440}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00125	DAP	Transfer from AT1G03840	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_008229114.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by the transcription factor JKD, and down-regulated by SHR, SCR and itself. {ECO:0000269\|PubMed:21935722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008229114.1	0.0	PREDICTED: zinc finger protein NUTCRACKER-like
Swissprot	Q9ZWA6	1e-142	IDD3_ARATH; Zinc finger protein MAGPIE
TrEMBL	A0A251Q0I2	0.0	A0A251Q0I2_PRUPE; Uncharacterized protein
STRING	XP_008229114.1	0.0	(Prunus mume)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4626	29	51

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	1e-131	C2H2 family protein

Publications ? help Back to Top
Muñoz-Strale D,León G Identification of two highly specific pollen promoters using transcriptomic data. Plant Physiol. Biochem., 2014. 83: p. 292-9 [PMID:25208507] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755]