PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Cicereae; Cicer

Family

C2H2

Protein Properties

Length: 506aa MW: 55834 Da PI: 8.2718

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_004494352.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	17.2	1.4e-05	86	108	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H XP_004494352.1 86 FVCEICNKGFQRDQNLQLHRRGH 108 89*******************88 PP
2	zf-C2H2	16.2	2.9e-05	162	184	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k++ +s+ k H++t+ XP_004494352.1 162 WKCDKCSKRYAVQSDWKAHQKTC 184 58*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	3.77E-8	85	108	No hit	No description
Gene3D	G3DSA:3.30.160.60	1.7E-5	85	108	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Pfam	PF12171	8.1E-5	86	108	IPR022755	Zinc finger, double-stranded RNA binding
SMART	SM00355	0.017	86	108	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.949	86	108	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	88	108	IPR007087	Zinc finger, C2H2
SMART	SM00355	96	127	157	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	2.7E-5	150	183	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	3.77E-8	157	183	No hit	No description
SMART	SM00355	89	162	182	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 506 aa Download sequence Send to blast
MSNISGDEGS FSSGNNGEEV YQESKQQQLQ NHLNNESSSG PSGACNSNGS TNQQQNKKKR 60 NLPGTPDPTA EVVALSPTTL MATNRFVCEI CNKGFQRDQN LQLHRRGHNL PWKLRQRTST 120 EVKKKVYVCP EPSCVHHNPA RALGDLTGIK KHFSRKHGEK KWKCDKCSKR YAVQSDWKAH 180 QKTCGTREYK CDCGTIFSRR DSFITHRAFC DALTEENNRV NQGLTSGMPP NLQNQMPDHM 240 STMPLKPCSN TPSELNNDYD PKNSLRSPPQ ELVPTIPFRS TNNACGGMFS TTSGALFGGP 300 KALTPTSSSL QLSSNSFNYF HDSKNGSAQM SATALLQKAA QMGATASNSG NSSMMQKSFV 360 SSMVGPDHVS ASARPPYSSS SIMMQHNMPS YEHFDLSNMT NVSGGGAFTN QLFQKEQHEI 420 SVLFDNNNST SVSTMNNDIG LFNQISMRND VAGNDMTRVH DFLGIGGSNS SLHEPVLSQQ 480 RLEIMNNFHH HLPHEDSAIE KSIWDV

Sequence ? help Back to Top

Protein Sequence Length: 506 aa Download sequence Send to blast

MSNISGDEGS FSSGNNGEEV YQESKQQQLQ NHLNNESSSG PSGACNSNGS TNQQQNKKKR  60
NLPGTPDPTA EVVALSPTTL MATNRFVCEI CNKGFQRDQN LQLHRRGHNL PWKLRQRTST  120
EVKKKVYVCP EPSCVHHNPA RALGDLTGIK KHFSRKHGEK KWKCDKCSKR YAVQSDWKAH  180
QKTCGTREYK CDCGTIFSRR DSFITHRAFC DALTEENNRV NQGLTSGMPP NLQNQMPDHM  240
STMPLKPCSN TPSELNNDYD PKNSLRSPPQ ELVPTIPFRS TNNACGGMFS TTSGALFGGP  300
KALTPTSSSL QLSSNSFNYF HDSKNGSAQM SATALLQKAA QMGATASNSG NSSMMQKSFV  360
SSMVGPDHVS ASARPPYSSS SIMMQHNMPS YEHFDLSNMT NVSGGGAFTN QLFQKEQHEI  420
SVLFDNNNST SVSTMNNDIG LFNQISMRND VAGNDMTRVH DFLGIGGSNS SLHEPVLSQQ  480
RLEIMNNFHH HLPHEDSAIE KSIWDV

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	2e-35	158	221	3	66	Zinc finger protein JACKDAW
5b3h_F	2e-35	158	221	3	66	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	XP_004494352.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC144504	1e-159	AC144504.14 Medicago truncatula clone mth2-34c9, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_004494352.1	0.0	zinc finger protein GAI-ASSOCIATED FACTOR 1-like
Swissprot	Q9SCQ6	1e-114	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A1S2XUY1	0.0	A0A1S2XUY1_CICAR; zinc finger protein GAI-ASSOCIATED FACTOR 1-like
STRING	XP_004494352.1	0.0	(Cicer arietinum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G50700.1	1e-113	indeterminate(ID)-domain 2

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]