PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Vigna

Family

E2F/DP

Protein Properties

Length: 382aa MW: 43166.4 Da PI: 9.4598

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Vang11g12260.1	genome	SNU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	75.8	4.3e-24	16	81	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rk+ksL+ll+++fl+l+++ + + l+++a++L v +rRRiYDi+NVLe+++++++k+kn+++wkg Vang11g12260.1 16 RKQKSLGLLCTNFLSLYNRDTVHLIGLDDAATRL---GV--ERRRIYDIVNVLESIGVLSRKAKNQYTWKG 81 79***************999********.....****************************98 PP
2	E2F_TDP	76.9	2e-24	152	232	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 r+eksL lltq+f+kl+ +s+ + ++l+e+ak L+ + +++k+RR+YDi+NVL+++nliek ++k+++rw g Vang11g12260.1 152 RREKSLALLTQNFVKLFVCSNVELISLDEAAKLLLGDahntsIMRTKVRRLYDIANVLSSMNLIEKthtsdTRKPAFRWLG 232 689************************************999**********************99*****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	4.9E-26	12	82	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.55E-16	15	79	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.1E-28	16	81	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.0E-20	17	81	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	2.6E-23	149	234	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	8.7E-32	152	232	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	6.03E-14	154	233	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.4E-19	154	232	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0032876	Biological Process	negative regulation of DNA endoreduplication
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 382 aa Download sequence Send to blast
MTSSDPISSK HYTYNRKQKS LGLLCTNFLS LYNRDTVHLI GLDDAATRLG VERRRIYDIV 60 NVLESIGVLS RKAKNQYTWK GFAAIPLTLR ELKEDGLREN SSSLRGSTND DMYKVSDDED 120 DEETQSNAAT GSQNDKLNPK STQPRSLKNE NRREKSLALL TQNFVKLFVC SNVELISLDE 180 AAKLLLGDAH NTSIMRTKVR RLYDIANVLS SMNLIEKTHT SDTRKPAFRW LGPEGKTWNE 240 SLHKSNQNES RKRAFGSDIT NISFERNKVE LFTNGDLNSN PKKLKIENDR GLDQADENNL 300 KQGTKQTSKS YQFGPFAPAC VPGVGASGNN NVKQVHDWDG LVTTHSPQYQ NEALRDLFSH 360 YMEAWKSWYS EIAAKRPLKI L*

Sequence ? help Back to Top

Protein Sequence Length: 382 aa Download sequence Send to blast

MTSSDPISSK HYTYNRKQKS LGLLCTNFLS LYNRDTVHLI GLDDAATRLG VERRRIYDIV  60
NVLESIGVLS RKAKNQYTWK GFAAIPLTLR ELKEDGLREN SSSLRGSTND DMYKVSDDED  120
DEETQSNAAT GSQNDKLNPK STQPRSLKNE NRREKSLALL TQNFVKLFVC SNVELISLDE  180
AAKLLLGDAH NTSIMRTKVR RLYDIANVLS SMNLIEKTHT SDTRKPAFRW LGPEGKTWNE  240
SLHKSNQNES RKRAFGSDIT NISFERNKVE LFTNGDLNSN PKKLKIENDR GLDQADENNL  300
KQGTKQTSKS YQFGPFAPAC VPGVGASGNN NVKQVHDWDG LVTTHSPQYQ NEALRDLFSH  360
YMEAWKSWYS EIAAKRPLKI L*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	6e-40	15	224	3	228	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00397	DAP	Transfer from AT3G48160	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Vang11g12260.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_014507184.1	0.0	E2F transcription factor-like E2FE isoform X2
Swissprot	Q8LSZ4	1e-126	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A0S3R6A4	0.0	A0A0S3R6A4_PHAAN; Uncharacterized protein
STRING	XP_007155383.1	0.0	(Phaseolus vulgaris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3668	33	66

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	1e-128	DP-E2F-like 1

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]