PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Vigna

Family

E2F/DP

Protein Properties

Length: 378aa MW: 42830 Da PI: 8.4067

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Vang09g01270.2	genome	SNU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	57	3.3e-18	23	78	11	71
E2F_TDP 11 qkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 +fl+l+++ + + l+++a++L v +rRRiYDi+NVLe+++++++k+kn+++wkg Vang09g01270.2 23 CSFLRLYNRDGVRLIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLARKAKNQYTWKG 78 579***9999********.....****************************98 PP
2	E2F_TDP	76.1	3.4e-24	148	227	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 r+eksL lltq+f+kl+ +s+ ++++l+e+ak L+ + +++k+RR+YDi+NVL+++nliek ++k+++rw g Vang09g01270.2 148 RREKSLALLTQNFVKLFICSSIEMISLDEAAKLLLGNantsIMRTKVRRLYDIANVLSSMNLIEKthttnTRKPAFRWLG 227 689*****************************999999999*********************999*****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	3.9E-16	18	78	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.67E-12	22	76	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	6.7E-19	22	80	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	5.1E-15	23	78	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	1.7E-23	144	227	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.3E-29	148	227	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.01E-12	150	228	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.3E-19	150	227	IPR003316	E2F/DP family, winged-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 378 aa Download sequence Send to blast
LLLSIASIQF NFILYFSRAS SSCSFLRLYN RDGVRLIGLD DAASRLGVER RRIYDIVNVL 60 ESVGVLARKA KNQYTWKGFS AIPEALQELK EDGLKENPGS FDDSNDSAKV SDDEDEEETS 120 PIVNTESQND KEIPDSTALG LSSKNENRRE KSLALLTQNF VKLFICSSIE MISLDEAAKL 180 LLGNANTSIM RTKVRRLYDI ANVLSSMNLI EKTHTTNTRK PAFRWLGWRG KAWSESVDLA 240 HNSNFNEPGK RKFGTDITNT SFKRSKTDFL LDGLTCKMQN QQENISYRVQ LDRSNFEKDA 300 KQTSKGYQFG PFAPAYVPKV GTSENNSGNQ VHDWDSLAQV HRPQYQNQAL RDLFSHYMDA 360 WKSWYSEVAE KKPTKTL*

Sequence ? help Back to Top

Protein Sequence Length: 378 aa Download sequence Send to blast

LLLSIASIQF NFILYFSRAS SSCSFLRLYN RDGVRLIGLD DAASRLGVER RRIYDIVNVL  60
ESVGVLARKA KNQYTWKGFS AIPEALQELK EDGLKENPGS FDDSNDSAKV SDDEDEEETS  120
PIVNTESQND KEIPDSTALG LSSKNENRRE KSLALLTQNF VKLFICSSIE MISLDEAAKL  180
LLGNANTSIM RTKVRRLYDI ANVLSSMNLI EKTHTTNTRK PAFRWLGWRG KAWSESVDLA  240
HNSNFNEPGK RKFGTDITNT SFKRSKTDFL LDGLTCKMQN QQENISYRVQ LDRSNFEKDA  300
KQTSKGYQFG PFAPAYVPKV GTSENNSGNQ VHDWDSLAQV HRPQYQNQAL RDLFSHYMDA  360
WKSWYSEVAE KKPTKTL*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	8e-32	37	219	32	228	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Vang09g01270.2

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AP015035	0.0	AP015035.1 Vigna angularis var. angularis DNA, chromosome 2, almost complete sequence, cultivar: Shumari.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017419843.1	0.0	PREDICTED: E2F transcription factor-like E2FE isoform X1
Swissprot	Q8LSZ4	1e-113	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A0S3RGB4	0.0	A0A0S3RGB4_PHAAN; Uncharacterized protein
STRING	XP_007138128.1	0.0	(Phaseolus vulgaris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3668	33	66

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.2	1e-116	DP-E2F-like 1

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]