PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Vigna

Family

E2F/DP

Protein Properties

Length: 492aa MW: 54398.1 Da PI: 5.291

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Vang06g25180.1	genome	SNU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	84.7	7e-27	182	247	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Vang06g25180.1 182 RYDSSLGLLTKKFINLVKHAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 247 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.2E-29	179	249	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.2E-34	182	247	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	7.21E-17	182	245	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.9E-24	184	247	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	3.92E-27	260	377	No hit	No description
CDD	cd14660	1.11E-44	260	377	No hit	No description
Pfam	PF16421	3.4E-29	263	375	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 492 aa Download sequence Send to blast
MSTAAGPPDR RASPPRGTAG TTIRPALKRH LAFVTKPPFA PPDDYHSFSS IDSRRLADEA 60 VVVRSPVSTS VSSARSQIHL RGSRIWNVLF CVECDYMKRK GGMNDSEGES HTQKWSNSPG 120 YTNVSNITNS PFKTPVSAKG GRTQKAKASK EGRSCPPTPI SNADSFSDSG SPSPLTPASS 180 CRYDSSLGLL TKKFINLVKH AEDGILDLNK AAETLEVQKR RIYDITNVLE GIGLIEKKLK 240 NRIHWKGIES STSGEVDGDI SVLKEEVEKL SLEEQGLDDQ IREMQERLRK LSENENNRKC 300 LFVTEDDIKS LPCFQVFLLL ILAYSCKQNE TLIAIKAPHG TTLEVPDPEE AVDYPQRRYR 360 IILRSTMGPI DVYLISQFEE KFEEINGAEL PMIPLASSSE SNEQVMTEMV PAECSGKEFE 420 PQTQLSSHND ADYWLLSDAD VSITDMWRTD STVDWNGVDM LNPDFGIISR PQTPSSGFVE 480 VPTPGANSNH K*

Sequence ? help Back to Top

Protein Sequence Length: 492 aa Download sequence Send to blast

MSTAAGPPDR RASPPRGTAG TTIRPALKRH LAFVTKPPFA PPDDYHSFSS IDSRRLADEA  60
VVVRSPVSTS VSSARSQIHL RGSRIWNVLF CVECDYMKRK GGMNDSEGES HTQKWSNSPG  120
YTNVSNITNS PFKTPVSAKG GRTQKAKASK EGRSCPPTPI SNADSFSDSG SPSPLTPASS  180
CRYDSSLGLL TKKFINLVKH AEDGILDLNK AAETLEVQKR RIYDITNVLE GIGLIEKKLK  240
NRIHWKGIES STSGEVDGDI SVLKEEVEKL SLEEQGLDDQ IREMQERLRK LSENENNRKC  300
LFVTEDDIKS LPCFQVFLLL ILAYSCKQNE TLIAIKAPHG TTLEVPDPEE AVDYPQRRYR  360
IILRSTMGPI DVYLISQFEE KFEEINGAEL PMIPLASSSE SNEQVMTEMV PAECSGKEFE  420
PQTQLSSHND ADYWLLSDAD VSITDMWRTD STVDWNGVDM LNPDFGIISR PQTPSSGFVE  480
VPTPGANSNH K*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	5e-25	177	248	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Vang06g25180.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AP015041	1e-157	AP015041.1 Vigna angularis var. angularis DNA, chromosome 8, almost complete sequence, cultivar: Shumari.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_017407031.1	0.0	PREDICTED: transcription factor E2FA
Swissprot	Q9FNY0	1e-132	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A0L9T8L3	0.0	A0A0L9T8L3_PHAAN; Uncharacterized protein
STRING	XP_007145806.1	0.0	(Phaseolus vulgaris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1947	34	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-123	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]