PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Traes_6AS_9596E4B58.1
Organism
Triticum aestivum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Triticinae; Triticum
Family E2F/DP
Protein Properties Length: 458aa    MW: 49949.7 Da    PI: 4.8201
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Traes_6AS_9596E4B58.1genomeIWGSCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP85.83.3e-27146211171
                E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                            r+++sL+llt+kf++ll+++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  Traes_6AS_9596E4B58.1 146 RYDSSLGLLTKKFINLLKQAEDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 211
                            6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.3E-29143213IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-34146211IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.77E-18146209IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.2E-24148211IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146604.25E-47221327No hitNo description
SuperFamilySSF1440747.32E-33224327No hitNo description
PfamPF164212.3E-32226325IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 458 aa     Download sequence    Send to blast
MSGGGRPPAA QKILQSLRPP PVFSTPSRPP FASPDDYHRF HAPTTPSATG SGGIGSGGVG  60
GDIDEGLVIR TQLKRKATRE ENNAAESSDC MIVTTGVTGN PLLTPVSGKA VKNSKSKTKN  120
NKAGPQTPTP NVGSPLNPST PAGTCRYDSS LGLLTKKFIN LLKQAEDGIL DLNNAAETLE  180
VQKRRIYDIT NVLEGIGLIE KTLKNRIRWK GLDDSGVELD NGLSGLQTEV ENLNLQEQAL  240
DERISDMREK LRGLTEDENS QRWLYVTEDD IKGLPCFQNE TLIAIKAPHG TTLEVPDPDE  300
AGDYLQRRYR IVLRSTLGPI DVYLVSQFDD GFENLGGAAT PPRHTNVPKP GPCEDLHATN  360
ATQSSKSINV EYNIQHRQNT PQDPSSSNDY GGMTRIIPSD VNTDADYWLL TEGDVSITDM  420
WETAPEVQWD TAVFLPEDVS IPHAHHSPRM QVPSMDQP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A3e-24138212274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ2385900.0AJ238590.1 Triticum sp. mRNA for E2F protein.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020183251.10.0transcription factor E2FA-like isoform X1
SwissprotQ9FNY01e-127E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A3B6NPV30.0A0A3B6NPV3_WHEAT; Uncharacterized protein
TrEMBLA0A446VDU50.0A0A446VDU5_TRITD; Uncharacterized protein
TrEMBLQ9ST550.0Q9ST55_9POAL; E2F protein
STRINGTraes_6AS_9596E4B58.10.0(Triticum aestivum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MonocotsOGMP62537148
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-120E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]
  2. Brenchley R, et al.
    Analysis of the bread wheat genome using whole-genome shotgun sequencing.
    Nature, 2012. 491(7426): p. 705-10
    [PMID:23192148]