PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Traes_5DL_26C867084.2

Organism

Triticum aestivum

Taxonomic ID

4565

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Pooideae; Triticodae; Triticeae; Triticinae; Triticum

Family

E2F/DP

Protein Properties

Length: 444aa MW: 48672.6 Da PI: 4.4642

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Traes_5DL_26C867084.2	genome	IWGSC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	83	2.4e-26	131	196	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kfl+ll+ ++ g+v+ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg Traes_5DL_26C867084.2 131 RYDSSLGLLTKKFLNLLKGAPGGMVDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNNIRWKG 196 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.9E-28	129	197	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	1.77E-16	131	194	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.0E-34	131	196	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.9E-23	133	196	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.12E-49	207	313	No hit	No description
SuperFamily	SSF144074	8.89E-33	208	313	No hit	No description
Pfam	PF16421	3.1E-33	212	311	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 444 aa Download sequence Send to blast
MAAAAGGTSS EGAARVLLQR YQPFGSPPGD YHHFGPADGG GSAEMTEAVV LRTPLKRKHN 60 REDNEVTESN DWMMSPGYAN ATNSPIPTPP SGKGSKMSAK PKAAKGQKSC PQTPLFSGSP 120 GNPATPVGGC RYDSSLGLLT KKFLNLLKGA PGGMVDLNNA AETLEVQKRR IYDITNVLEG 180 IGLIEKKLKN NIRWKGIDDS RPGEVSDDMS ILQGDIEALT LQEHSLDGQI SEMRDKLREL 240 TEDENNQKWL YVTEHDIKSL PCFQNQTLIA IKAPHGTTLE VPDPDEVNDY PQRRYRIVLR 300 STMGPIDVYL VSQFEEMSGM ETPPRSAQTI SMDYLENPRT PLATGSNKDV EMENVQQGLI 360 MPPDAPTTQD IGGMMKIVPS ELDTDADYWL LSDTGVSITD MWKTAPDVEW EGIDINAEDF 420 LEVGTPRQQD QPPSEMVDHP SCIS

Sequence ? help Back to Top

Protein Sequence Length: 444 aa Download sequence Send to blast

MAAAAGGTSS EGAARVLLQR YQPFGSPPGD YHHFGPADGG GSAEMTEAVV LRTPLKRKHN  60
REDNEVTESN DWMMSPGYAN ATNSPIPTPP SGKGSKMSAK PKAAKGQKSC PQTPLFSGSP  120
GNPATPVGGC RYDSSLGLLT KKFLNLLKGA PGGMVDLNNA AETLEVQKRR IYDITNVLEG  180
IGLIEKKLKN NIRWKGIDDS RPGEVSDDMS ILQGDIEALT LQEHSLDGQI SEMRDKLREL  240
TEDENNQKWL YVTEHDIKSL PCFQNQTLIA IKAPHGTTLE VPDPDEVNDY PQRRYRIVLR  300
STMGPIDVYL VSQFEEMSGM ETPPRSAQTI SMDYLENPRT PLATGSNKDV EMENVQQGLI  360
MPPDAPTTQD IGGMMKIVPS ELDTDADYWL LSDTGVSITD MWKTAPDVEW EGIDINAEDF  420
LEVGTPRQQD QPPSEMVDHP SCIS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-22	123	197	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020177970.1	0.0	transcription factor E2FA-like
Swissprot	Q9FNY0	1e-123	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A3B6MQ31	0.0	A0A3B6MQ31_WHEAT; Uncharacterized protein
STRING	Traes_5DL_26C867084.2	0.0	(Triticum aestivum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-116	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083] Brenchley R, et al. Analysis of the bread wheat genome using whole-genome shotgun sequencing. Nature, 2012. 491(7426): p. 705-10 [PMID:23192148]