PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassicaceae incertae sedis; Schrenkiella

Family

MYB

Protein Properties

Length: 967aa MW: 108838 Da PI: 5.2355

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Tp6g32090	genome	thellungiella	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	58.6	1.4e-18	41	87	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 rg WT+eEde+l +av+ + g++Wk+Ia+++ Rt+ qc +rwqk+l Tp6g32090 41 RGQWTAEEDEILRKAVHNFKGKNWKKIAEYFK-DRTDVQCLHRWQKVL 87 89***************************9.**********986 PP
2	Myb_DNA-binding	64.4	2.1e-20	93	139	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g+WT+eEde +v++++++G++ W+tIar+++ gR +kqc++rw+++l Tp6g32090 93 KGPWTKEEDEMIVQLIQKYGPKKWSTIARYLP-GRIGKQCRERWHNHL 139 79****************************.***********97 PP
3	Myb_DNA-binding	43	1.1e-13	145	187	1	45
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwq 45 + +WT+eE++ l++a++ +G++ W+ + ++ gR+++ +k++w+ Tp6g32090 145 KEAWTQEEELVLIRAHQIYGNR-WAELTKFLP-GRSDNGIKNHWH 187 579*****************.*****.*********8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	19.039	36	87	IPR017930	Myb domain
SuperFamily	SSF46689	2.3E-15	38	93	IPR009057	Homeodomain-like
SMART	SM00717	2.9E-15	40	89	IPR001005	SANT/Myb domain
Pfam	PF00249	1.8E-16	41	87	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	7.9E-23	42	95	IPR009057	Homeodomain-like
CDD	cd00167	1.11E-13	44	87	No hit	No description
PROSITE profile	PS51294	32.745	88	143	IPR017930	Myb domain
SuperFamily	SSF46689	1.91E-31	90	186	IPR009057	Homeodomain-like
SMART	SM00717	2.1E-19	92	141	IPR001005	SANT/Myb domain
Pfam	PF00249	2.9E-18	93	139	IPR001005	SANT/Myb domain
CDD	cd00167	7.43E-17	95	139	No hit	No description
Gene3D	G3DSA:1.10.10.60	3.9E-27	96	143	IPR009057	Homeodomain-like
SMART	SM00717	1.5E-12	144	192	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	1.6E-19	144	194	IPR009057	Homeodomain-like
PROSITE profile	PS51294	18.094	144	194	IPR017930	Myb domain
Pfam	PF00249	9.7E-12	145	187	IPR001005	SANT/Myb domain
CDD	cd00167	1.21E-9	147	187	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0032875	Biological Process	regulation of DNA endoreduplication
GO:0003677	Molecular Function	DNA binding
GO:0003713	Molecular Function	transcription coactivator activity

Sequence ? help Back to Top
Protein Sequence Length: 967 aa Download sequence Send to blast
MESECTTTIS TPPEGLIEGN PNPKSQSRHG RTSGPARRST RGQWTAEEDE ILRKAVHNFK 60 GKNWKKIAEY FKDRTDVQCL HRWQKVLNPE LVKGPWTKEE DEMIVQLIQK YGPKKWSTIA 120 RYLPGRIGKQ CRERWHNHLN PAINKEAWTQ EEELVLIRAH QIYGNRWAEL TKFLPGRSDN 180 GIKNHWHSSV KKKLDSYMSS GLLDQYQAMP LAPYEKSSTL QSAFMQSTTD GNGCVSGQAE 240 KQKENCQISS MAGCSISARD YQNGIINMGQ HFHTSERAAY HSDHYYYPEL EDISVSISEV 300 SYDMEDCSQV PDHNVSNSSS QDYQFDFQDL SDISLEMRHN MSELLMPYTK ESEESALRAP 360 NSTSNIDVAT YTNPANVSTS ETECCRVLFL DQESEGLSIS RSSTQEPNEV DQPDYQDPVF 420 CASALDSQIS EATKSPMQSS SSRSIATASS SKETLRPAPL IISPDKYAKK SSGLICHPFE 480 AEPNCRRNEN GSFICLNDPS NSTCVDEGPN STEEDQSYHL NDSIKLVPVN DFASMAEFKP 540 HSLPKHEPKM TSEQHHEDTG ASSSLSFPSL DVPVFNCDLL QSKNDPLHDY SPLGIRKLLM 600 STMTCMSPLR LWESPTGKKT LVGAKSILRK RTRDLLTPLS EKRSDKKLET DIAASLAKDF 660 SRLDVMFDES ESREPISGNS TGVNVGDTEN HFQILNGEGE ENWRGMAFSL FNHRMPEEIV 720 HRRKSLEKAD QTCLEATVRE KGDSEPDVEN VESFSGVLSE NNTNKELLSP PAQSVTKAEK 780 AQVSRPRNQL QRTPVATSNK EQHCSSSLCL VINSPSRTRN TEGHFVDNET SNENFTIFYG 840 TPFKRGLESP SAWKSPFYVN SLLPSPRFDT EITIEDMGYI FSPGERSYES IGVMTQRNEH 900 ASAFAAFDAM EVSLSPSNDD DARKMKELDK ENNDPLLVER RVLDFNDCDS PTKVKEEVSS 960 YLLKGCR

Sequence ? help Back to Top

Protein Sequence Length: 967 aa Download sequence Send to blast

MESECTTTIS TPPEGLIEGN PNPKSQSRHG RTSGPARRST RGQWTAEEDE ILRKAVHNFK  60
GKNWKKIAEY FKDRTDVQCL HRWQKVLNPE LVKGPWTKEE DEMIVQLIQK YGPKKWSTIA  120
RYLPGRIGKQ CRERWHNHLN PAINKEAWTQ EEELVLIRAH QIYGNRWAEL TKFLPGRSDN  180
GIKNHWHSSV KKKLDSYMSS GLLDQYQAMP LAPYEKSSTL QSAFMQSTTD GNGCVSGQAE  240
KQKENCQISS MAGCSISARD YQNGIINMGQ HFHTSERAAY HSDHYYYPEL EDISVSISEV  300
SYDMEDCSQV PDHNVSNSSS QDYQFDFQDL SDISLEMRHN MSELLMPYTK ESEESALRAP  360
NSTSNIDVAT YTNPANVSTS ETECCRVLFL DQESEGLSIS RSSTQEPNEV DQPDYQDPVF  420
CASALDSQIS EATKSPMQSS SSRSIATASS SKETLRPAPL IISPDKYAKK SSGLICHPFE  480
AEPNCRRNEN GSFICLNDPS NSTCVDEGPN STEEDQSYHL NDSIKLVPVN DFASMAEFKP  540
HSLPKHEPKM TSEQHHEDTG ASSSLSFPSL DVPVFNCDLL QSKNDPLHDY SPLGIRKLLM  600
STMTCMSPLR LWESPTGKKT LVGAKSILRK RTRDLLTPLS EKRSDKKLET DIAASLAKDF  660
SRLDVMFDES ESREPISGNS TGVNVGDTEN HFQILNGEGE ENWRGMAFSL FNHRMPEEIV  720
HRRKSLEKAD QTCLEATVRE KGDSEPDVEN VESFSGVLSE NNTNKELLSP PAQSVTKAEK  780
AQVSRPRNQL QRTPVATSNK EQHCSSSLCL VINSPSRTRN TEGHFVDNET SNENFTIFYG  840
TPFKRGLESP SAWKSPFYVN SLLPSPRFDT EITIEDMGYI FSPGERSYES IGVMTQRNEH  900
ASAFAAFDAM EVSLSPSNDD DARKMKELDK ENNDPLLVER RVLDFNDCDS PTKVKEEVSS  960
YLLKGCR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h88_C	2e-68	41	194	6	159	MYB PROTO-ONCOGENE PROTEIN
1h89_C	2e-68	41	194	6	159	MYB PROTO-ONCOGENE PROTEIN
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (PubMed:21862669). Involved in the regulation of cytokinesis, probably via the activation of several G2/M phase-specific genes transcription (e.g. KNOLLE) (PubMed:17287251, PubMed:21862669, PubMed:25806785). Required for the maintenance of diploidy (PubMed:21862669). {ECO:0000269\|PubMed:17287251, ECO:0000269\|PubMed:21862669, ECO:0000269\|PubMed:25806785}.; FUNCTION: Involved in transcription regulation during induced endoreduplication at the powdery mildew (e.g. G.orontii) infection site, thus promoting G.orontii growth and reproduction. {ECO:0000269\|PubMed:20018666}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00505	DAP	Transfer from AT5G11510	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Tp6g32090

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Slightly induced by salicylic acid (SA) (PubMed:16463103). Expressed in a cell cycle-dependent manner, with highest levels 2 hours before the peak of mitotic index in cells synchronized by aphidicolin. Activated by CYCB1 (PubMed:17287251). Accumulates at powdery mildew (e.g. G.orontii) infected cells. {ECO:0000269\|PubMed:16463103, ECO:0000269\|PubMed:17287251}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF371975	0.0	AF371975.2 Arabidopsis thaliana putative c-myb-like transcription factor MYB3R-4 (MYB3R4) mRNA, complete cds.
GenBank	AY519650	0.0	AY519650.1 Arabidopsis thaliana MYB transcription factor (At5g11510) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006399657.1	0.0	transcription factor MYB3R-4
Swissprot	Q94FL9	0.0	MB3R4_ARATH; Transcription factor MYB3R-4
TrEMBL	V4KT42	0.0	V4KT42_EUTSA; Uncharacterized protein
STRING	XP_006399657.1	0.0	(Eutrema salsugineum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM13213	18	28

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G11510.1	0.0	myb domain protein 3r-4

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Saito T, et al. Genetic interaction between G2/M phase-specific transcription factor MYB3R4 and MAPKKK ANP3 for execution of cytokinesis in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(3): p. e990817 [PMID:25806785] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Chen P, et al. Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]