PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Tp57577_TGAC_v2_mRNA38833
Organism
Trifolium pratense
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Trifolium
Family E2F/DP
Protein Properties Length: 378aa    MW: 42665.7 Da    PI: 8.4293
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Tp57577_TGAC_v2_mRNA38833genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP76.82.1e-241883171
                    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                               rk+ksL+ll+++fl+l+++ + ++v l+++a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Tp57577_TGAC_v2_mRNA38833 18 RKQKSLGLLCTNFLSLYNRDDVRVVGLDDAAGRL---GV--ERRRIYDIVNVLESIGVLQRKAKNQYTWKG 83
                               79*****************999************...**..****************************98 PP
2E2F_TDP75.65.1e-24159239171
                    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                                r+eksL lltq+f+kl+ +s+ ++++l+++a+ L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Tp57577_TGAC_v2_mRNA38833 159 RREKSLALLTQNFVKLFVCSNLEMISLDDAARLLLGDaynssTMRTKVRRLYDIANVLTSMNLIEKthttdTRKPAFRWLG 239
                                689*******************************************************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.6E-261484IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.38E-161781IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.3E-291883IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.7E-201983IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.104.8E-23156241IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.7E-29159239IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.9E-19161239IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.62E-13161240IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 378 aa     Download sequence    Send to blast
MASSSDPPPS SRHHTYDRKQ KSLGLLCTNF LSLYNRDDVR VVGLDDAAGR LGVERRRIYD  60
IVNVLESIGV LQRKAKNQYT WKGFGAIPVA LQELKEEGLW QNSQEGGNED TKVSDEEDED  120
ESLSQPTGSQ GESLSQPTGC QNDILNPNSA FPRSLKNDRR EKSLALLTQN FVKLFVCSNL  180
EMISLDDAAR LLLGDAYNSS TMRTKVRRLY DIANVLTSMN LIEKTHTTDT RKPAFRWLGL  240
KGKTWNEASL SRKRAFGNDV TNISFGRNRT DSFMGGDFSQ NLKKQKTMEN DSGLCQDDKN  300
NMKQKQSYQF GPFAPAYVSK AGTSENKVKQ VHDWESLATE HCPQYQNQAL KELYSHYMEA  360
WKSWYSEVAG KRSTQVL*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A8e-42182314228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapTp57577_TGAC_v2_mRNA38833
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013457830.10.0E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-122E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2K3NVN50.0A0A2K3NVN5_TRIPR; E2F transcription factor-like E2Fe-like protein
STRINGAES911280.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-114DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]