PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Tp4g18270
Organism
Thellungiella parvula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassicaceae incertae sedis; Schrenkiella
Family E2F/DP
Protein Properties Length: 486aa    MW: 52865 Da    PI: 4.697
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Tp4g18270genomethellungiellaView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP82.24.3e-26167232171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                r+++sL+llt+kf++l++++++g+++ln++a++L   +v  ++RRiYDi+NVLe+++liek  kn+i wkg
  Tp4g18270 167 RYDSSLGLLTKKFVNLIKQAKDGMLDLNKAAETL---EV--QKRRIYDITNVLEGIDLIEKPLKNRILWKG 232
                6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.108.4E-28164234IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.9E-16167230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-32167232IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023197.7E-23169232IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440743.66E-32245349No hitNo description
CDDcd146602.54E-48245349No hitNo description
PfamPF164211.2E-32249347IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 486 aa     Download sequence    Send to blast
MSGGVRSSPG PSQPPPPPPQ HPPSSPSPAA SVPVVPPIRR HLAFASTKPP FHPSDDYHRF  60
TPAYLTNNDI SLVNGCGIVD REEDAVVVRS PSRKRKSTMD VVTAPSNNGF TSSGFTSIPN  120
SPCQTPVSAK GGRVNIKSKA KGNQSIPQTP ISSVGSPATL TPTGSCRYDS SLGLLTKKFV  180
NLIKQAKDGM LDLNKAAETL EVQKRRIYDI TNVLEGIDLI EKPLKNRILW KGVDALRPGD  240
VDTDVSVVQA EIENLSLEEQ ALDNQIRETE ERLRDLSENE KNQKWLFVTE EDIKSLPGFQ  300
NQTLIAVKAP HGTTLEVPDP DEAVDHPQRR YRIILRSTMG PIDVYLVSEF EGKFEDTNGT  360
AAPAACLPIA SCSGSTENHD IEALNVDNTR TAVEHQLSQD HAHAQPGDTS DLNYLQEQVG  420
GMLKITPSDV ENDDTDYWLL SNAEISMTDI WKTDSGIDWD YGIADVSTPP PVTGEIAPTA  480
IDSTPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-23167233774PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
19196SRKRKS
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapTp4g18270
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF2425820.0AF242582.1 Arabidopsis thaliana E2F transcription factor-3 E2F3 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006410774.10.0transcription factor E2FA
SwissprotQ9FNY00.0E2FA_ARATH; Transcription factor E2FA
TrEMBLV4MAR90.0V4MAR9_EUTSA; Uncharacterized protein
STRINGXP_006410774.10.0(Eutrema salsugineum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM80828121
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.10.0E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]